Colorado Rockies vs St. Louis Cardinals Prediction 07/21/2025 Picks

The Saint Louis Cardinals are visiting the Colorado Rockies on Monday, July 21^st at the Coors Field in the opening game of this series. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Saint Louis Cardinals vs Colorado Rockies Prediction. We will examine:

The Colorado Rockies’ recent form and player performance
The Saint Louis Cardinals’ recent form and player performance
Recent betting trends and streaks involving the Colorado Rockies
Recent betting trends and streaks involving the Saint Louis Cardinals
Recent betting trends in games played between the Saint Louis Cardinals vs Colorado Rockies
A summary that ties it all together and produces a favorable betting outcome for the Saint Louis Cardinals vs Colorado Rockies game

Colorado Rockies Preview

The Colorado Rockies have a 24-75 record this season and are sitting in last place in the NL West. The Rockies have a 12-37 home record and are 40-56 in over/under. They are coming off a 1-7 home defeat by the Twins, which ended their previous two-game winning streak. Under is 5-1 in their last 6 games, and they are playing the Guardians and the Orioles next.

The Rockies have a .233 batting average this season, a .292 OBP, and a .385 Slugging percentage. Colorado’s pitching staff has a 5.57 ERA and 1.57 WHIP. Hunter Goodman leads the Rockies with 92 hits, adding a team-high 55 RBI, and he is the team’s best hitter with a .279 batting average. He also adds a team-high 18 home runs.

Austin Gomber (L) is the projected starting pitcher for the Rockies, and he has a 0-3 record, 5.65 ERA, and 1.60 WHIP.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 51-49 record this season and are sitting in 4th place in the NL Central. The Cardinals have a 22-29 road record and are 53-43 in over/under. They are coming off a 3-5 road defeat by the D-backs, and are 1-5 in their last 6 games. Over is 9-2-1 in their last 12 games and are playing the Marlins and the Padres next.

The Cardinals have a .251 batting average this season, a .321 OBP, and a .392 Slugging percentage. Saint Louis’ pitching staff has a 4.19 ERA and 1.28 WHIP. Brendan Donovan leads the Cardinals with 103 hits and is the team’s best hitter with a .293 batting average. Wilson Contreras leads the team in RBI, with 55, adding a team-high 12 home runs.

Michael McGreevy (R) is the projected starting pitcher for the Cardinals, and he has a 1-1 record, 4.22 ERA, and 1.03 WHIP.

Why the Colorado Rockies will win

The Cardinals have lost each of their last seven games as road favorites against National League opponents following a loss.
The underdogs have won four of the Rockies’ last five games at Coors Field.
The Cardinals have failed to cover the run line in each of their last seven games as road favorites against National League opponents following a loss.
The underdogs have covered the run line in six of the Rockies’ last seven games at Coors Field.
The Cardinals have trailed after 3 innings in each of their last four road games.
The Cardinals have lost the first inning in three of their last four road games against National League opponents.
The Cardinals have trailed after 5 innings in each of their last four road games against National League opponents that held a losing record.

Why the St. Louis Cardinals will win

The Rockies have lost each of their last 12 night games against National League opponents following a home loss.
The Cardinals have won each of their last four night games against NL West opponents following a loss.
The Cardinals have covered the run line in each of their last seven night games following a loss.
The Rockies have failed to cover the run line in each of their last six night games following a home loss.
The Rockies have trailed after 3 innings in seven of their last eight home games against NL Central opponents that held a winning record.
The Rockies have trailed after 5 innings in five of their last six night games against NL Central opponents that held a winning record.

Total Runs Facts

Seven of the Rockies’ last eight games as underdogs against National League opponents have gone UNDER the total runs line.
Each of the Cardinals’ last four games as favorites have gone OVER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Rockies’ last six Monday games against National League opponents.
The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Cardinals’ last six road games.

Matchup/League Facts

The Rockies rank 1st in the league for triples this season (28).
The Rockies rank 30th in the league for on-base percentage this season (.292).
The Cardinals rank T29th in the league for triples this season (4).
The Cardinals rank 28th in the league for strikeouts this season (728).

Saint Louis Cardinals vs Colorado Rockies Prediction

The Cardinals are 3-1 in their last 4 overall meetings against the Rockies, and are 2-1 in their last three meetings in Colorado. Under is 5-3-1 in their last 9 meetings.   

In this Saint Louis Cardinals vs Colorado Rockies Prediction, the Cardinals are coming as -155 road favorites. The Cardinals are rightfully favored, as they have more than twice as many wins as the Rockies, but they have been struggling on the road. McGreevy has been excellent on the road for the Cardinals, with a 1.80 road ERA, while Gomber is struggling at home for the Rockies with a 7.36 home ERA. The Cardinals also have a better bullpen and a better offense, and I expect them to get the job done against an inferior Colorado squad today.