Cincinnati Reds shortstop Elly de la Cruz (44) takes off for first base on a two-run home run in the eighth inning of the MLB National League game between the Cincinnati Reds and the Colorado Rockies at Great American Ball Park in downtown Cincinnati on Tuesday, April 28, 2026. The Reds won the opening game of the series, 7-2.
Sam Greene/The Enquirer / USA TODAY NETWORK via Imagn Images

Colorado Rockies vs Cincinnati Reds Prediction 4/29/2026 Today’s MLB Picks

Pick details

MATCHUP Colorado Rockies Cincinnati Reds
Team Records 13-17 19-10
Where Great American Ball Park, Cincinnati, Ohio
When Wednesday, April 29, 2026
Time 06:40 PM EDT
TV MLB.TV

The Colorado Rockies and Cincinnati Reds meet Wednesday in MLB action at Great American Ball Park. Here’s a Colorado Rockies vs. Cincinnati Reds Prediction. This article will include a Colorado Rockies vs. Cincinnati Reds Pick.

Colorado Rockies Betting Preview


The Colorado Rockies are 13-17 on the year and play the Mets and Braves next. The Colorado Rockies are batting .249 on the season and have a .316 OBP, and a .393 slugging percentage. The Colorado Rockies pitching staff has a 4.19 ERA and a 1.37 WHIP. Troy Johnston leads the Colorado Rockies with 29 hits and 16 RBI while TJ Rumfield and Mickey Moniak have combined for 53 hits and 31 RBI.

Tomoyuki Sugano gets the ball for the Colorado Rockies, and he is 2-1 with a 3.42 ERA and 19 strikeouts this season. This will be Sugano’s first career game against the Cincinnati Reds.

Cincinnati Reds Betting Preview


The Cincinnati Reds are 19-10 on the year and play the Pirates and Cubs next. The Cincinnati Reds are batting. 218 on the season, have a .309 OBP, and have a .384 slugging percentage. The Cincinnati Reds pitching staff has a 3.71 ERA and a 1.40 WHIP. Elly De La Cruz leads the Cincinnati Reds with 34 hits and 24 RBI, while Sal Stewart and Matt McLain have combined for 53 hits and 38 RBI.

Brandon Williamson gets the ball for the Cincinnati Reds, and he is 2-2 with a 5.40 ERA and 15 strikeouts this season. Williamson is 0-0 with a 3.38 ERA and 11 strikeouts in his career against the Colorado Rockies.

Why the Cincinnati Reds will win

  • The Rockies have lost each of their last 10 road games against National League opponents following a road loss.
  • The Reds have won each of their last five night games after playing the previous day.
  • The Rockies have failed to cover the run line each of their last four road games against National League opponents that held a winning record.
  • The Reds have covered the run line in eight of their last 10 games.
  • The Rockies have lost the first inning in each of their last three games at Great American Ball Park against opponents that held a winning record.
  • The Reds have led after 3 innings in four of their last five games as favorites.
  • The Reds have led after 5 innings in four of their last five games as favorites.

Why the Colorado Rockies will win

  • The Reds have lost five of their last six games as favorites against NL West opponents following a home win.
  • The Rockies have won four of their last five games as underdogs following a loss.
  • The Rockies have covered the run line in each of their last five games as underdogs following a loss.
  • The Reds have failed to cover the run line in each of their last six Wednesday night games as home favorites against NL West opponents.

Total Runs Facts

  • Each of the Reds’ last four games has gone OVER the total runs line.
  • Nine of the Rockies’ last 12 road games against NL Central opponents have gone UNDER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in nine of the Reds’ last 10 games as favorites against National League opponents.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of the Rockies’ last 11 night games.

Cincinnati Reds Player Prop Facts

  • Tyler Stephenson has hit at least one home run in four of his five previous home appearances against the Rockies after playing the previous day.
  • Elly De La Cruz has recorded at least one hit in each of his 16 previous appearances with the Reds as a favorite against the Rockies.
  • Sal Stewart ranks 5th amongst qualified players for Slugging Percentage (.598) this season.

Colorado Rockies Player Prop Facts

  • Hunter Goodman has recorded at least one hit in each of his last 14 Wednesday appearances against NL teams that held a winning record.
  • Edouard Julien has hit a home run in two of the Rockies’ last three road games against NL opponents that held a winning record.

Matchup/League Facts

  • The Reds rank 28th in the league for strikeouts this season (227).
  • The Reds are one of only four teams in the league to rank top 10 in both steals and home runs this season.
  • The Rockies rank 4th in the league for doubles this season (55).
  • The Rockies rank 27th in the league for opponent batting average this season (.263).

Colorado Rockies vs Cincinnati Reds Prediction


I’m not excited to get behind Williamson and his 5.40 ERA and 1.52 WHIP, and he’s walked 16 in 25 innings. It’s not great. However, the Reds are playing better baseball overall, while the Rockies remain a below-average team that’s going to lose long term. It’s one of those spots where you just back the better team and believe things will work out. Not a great pitching matchup, but I’m rolling with the Reds at home with the cheap price.

Randy Chambers's Pick: Cincinnati Reds