Sep 3, 2025; St. Petersburg, Florida, USA; Seattle Mariners designated hitter Cal Raleigh (29) hits a RBI single in the sixth inning against the Tampa Bay Rays at George M. Steinbrenner Field. Mandatory Credit: Jonathan Dyer-Imagn Images

Cleveland Guardians vs Tampa Bay Rays Prediction 9/4/2025 Today’s MLB Picks

Pick details

Cleveland (69-69) vs Tampa Bay (70-69)

September 4, 2025 at 07:35 PM EDT

The Line: Betting Odds: Tampa Bay -1.5 — Over/Under: +8.5

(Get latest betting odds)

The Cleveland Guardians and Tampa Bay Rays meet Thursday in MLB action at George M. Steinbrenner Field. Here’s a Cleveland Guardians vs Tampa Bay Rays Prediction. This article will include a Cleveland Guardians vs Tampa Bay Rays Pick.

Cleveland Guardians Betting Preview


The Cleveland Guardians are 69-69 on the year and play the Royals, White Sox, and Tigers next. The Cleveland Guardians are batting .224 on the season, have a .294 OBP, and a .369 slugging percentage. The Cleveland Guardians pitching staff has a 3.97 ERA and a 1.32 WHIP. Steven Kwan leads the Cleveland Guardians with 145 hits and 44 RBI, while Jose Ramirez and Kyle Manzardo have combined for 131 hits and 131 RBI.

Logan Allen gets the ball for the Cleveland Guardians, and he is 7-10 with a 4.42 ERA and 105 strikeouts this season. This will be Allen’s second career game against the Tampa Bay Rays.

Tampa Bay Rays Betting Preview


The Tampa Bay Rays are 70-69 on the year and play the White Sox, Cubs, and Blue Jays next. The Tampa Bay Rays are batting .253 on the season, have a .314 OBP, and a .404 slugging percentage. The Tampa Bay Rays pitching staff has a 3.89 ERA and a 1.21 WHIP. Yandy Diaz leads the Tampa Bay Rays with 151 hits and 76 RBI, while Junior Caminero and Brandon Lowe have combined for 253 hits and 176 RBI.

Ryan Pepiot gets the ball for the Tampa Bay Rays, and he is 10-10 with a 3.70 ERA and 155 strikeouts this season. Pepiot is 1-0 with a 2.25 ERA and 11 strikeouts in his career against the Cleveland Guardians.

Cleveland Guardians vs Tampa Bay Rays Prediction

The Guardians continue to be hit or miss, and Allen is coming off a rough August where he allowed 28 hits and 17 earned runs in 25.2 innings. The Guardians are a tough sell night to night due to so much inconsistency. The Rays have won six straight games, and Pepiot has allowed 18 hits and 10 earned runs in his last 27.2 innings. Pepiot has a 3.25 ERA and .220 allowed batting average in 83 home innings. The Rays are the hotter side with the better pitcher. Give me the Rays.

Randy Chambers's Pick: Tampa Bay Rays

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