Cleveland Guardians vs Minnesota Twins Prediction 9/20/2025 Today’s MLB Picks

The Cleveland Guardians and the Minnesota Twins meet Saturday in MLB doubleheader action from Target Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cleveland Guardians vs. Minnesota Twins prediction.

Starting Pitching Matchup

The Cleveland Guardians will send out Slade Cecconi in game one and Cecconi is 6-6 with a 4.39 ERA and 98 strikeouts this season. Logan Allen will get the start in game two and is 7-11 with a 4.36 ERA and 111 strikeouts this season. The Minnesota Twins will start Joe Ryan in game one and Ryan is 13-8 with a 3.35 ERA and 180 strikeouts. Bailey Ober will get the start in game two and is 5-8 with a 5.12 ERA and 114 strikeouts this season.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to add on to their win over the Twins from Friday’s series opener to sit at 82-71 this season. After this series, the Guardians will head home for a rematch series against the Detroit Tigers.

Guardians Win Streak Hits 8

Steven Kwan has 159 hits as part of a .272 batting average and 10 home runs, 27 doubles and 49 RBIs. Kyle Manzardo has 104 hits with 17 doubles, 2 triples, 26 home runs and 67 RBIs as well this year. Gabriel Arias has 22 doubles but also 146 strikeouts and Manzardo has 123 strikeouts so far this season. Arias has also added 11 home runs and 50 RBIs and Jose Ramirez has chipped in 29 home runs and 80 RBIs with 39 stolen bases as well. 

Minnesota Twins Recap

The Minnesota Twins come into this game looking to rebound from their loss at the hands of the Guardians on Friday to fall to 66-87 on the year. After this set, the Twins will take to the road for a series against the Texas Rangers.

Twins Lose 7 Of Last 9

Byron Buxton has 119 hits along with 18 doubles, a team-high 31 home runs and 76 RBIs with 22 stolen bases and 7 triples while Trevor Larnach’s chipped in 119 hits with 21 doubles, 16 home runs and 58 RBIs as well this season. Brooks Lee has contributed 105 hits with 14 doubles, 14 home runs and 58 RBIs and Matt Wallner has 22 homers and 40 RBIs as well. 

Cleveland Guardians @ Minnesota Twins Betting Trends: September 20, 2025

Why the Minnesota Twins will win

• The Twins have won each of their last five day games against teams that held a winning record.
• The Guardians have lost 12 of their last 14 games on the first leg of a doubleheader.
• The Guardians have failed to cover the run line each of their last seven day games against AL Central opponents that held a losing record.
• The Twins have covered the run line each of their last six day games against teams that held a winning record.
• The Twins have led after 3 innings in each of their last four day games against the Guardians at Target Field.
• The Twins have won the first inning in three of their last four day games against AL Central opponents that held a winning record.
• The Twins have led after 5 innings in each of their last five day games against opponents that held a winning record.

Why the Cleveland Guardians will win

• The Guardians have won each of their last nine games as underdogs against the Twins following a win.
• The Twins have lost each of their last eight games as favorites against American League opponents.
• The Twins have failed to cover the run line in each of their last nine games as favorites.
• The Guardians have covered the run line in each of their last nine games as underdogs against the Twins following a win.
• The Twins have lost the first inning in each of their last three games.
• The Twins have trailed after 5 innings in five of their last six games.
• The Twins have trailed after 3 innings in 10 of their last 12 games as favorites against American League opponents.

Total Runs Facts

• Eight of the Guardians’ last nine games after playing the previous day have gone UNDER the total runs line.
• Five of the Twins’ last six games as favorites have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Guardians’ last six games as road underdogs.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Twins’ last five day games at Target Field.

Minnesota Twins Player Prop Facts

• Trevor Larnach has recorded a Double in four of his last five appearances in day games.
• Byron Buxton has hit a home run in four of his last five appearances in day games against teams that held a winning record.
• Joe Ryan has recorded six or more strikeouts in 10 of his last 11 home appearances against opponents that held a winning record.
• Trevor Larnach has recorded at least one hit in each of his last 11 appearances with the Twins as home favorites against AL opponents.
• Joe Ryan has recorded a win in four of his last five home appearances against AL Central opponents.
• Byron Buxton ranks 6th amongst qualified players for Slugging Percentage (.546) this season.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit a home run in two of the Guardians’ last three games against the Twins.
• Jose Ramirez has recorded a Double in five of the Guardians’ last six games at Target Field against opponents that held a losing record.
• Will Brennan has recorded at least one hit in each of his last 12 appearances with the Guardians as underdogs against the Twins.
• Jose Ramirez ranks 3rd in the league in Steals (40) this season.

Matchup/League Facts

• The Twins rank 27th in the league for opponent batting average this season (.260).
• The Twins rank 26th in the league for ERA this season (4.66).
• The Guardians rank 30th in the league for hits this season (1134).
• The Guardians rank 30th in the league for batting average this season (.226).

Cleveland Guardians vs. Minnesota Twins Prediction

I’m on the Guardians in both games. I just don’t want to step in front of Cleveland because this is what Cleveland does this late in the year. They make late playoff surges year after year and this year is no different. Minnesota’s just playing out the string at this point and aren’t even putting up a fight. I think the Guardians take both legs of the doubleheader. Give me Cleveland.