Cleveland Guardians vs Los Angeles Dodgers Prediction 4/1/2026 Today’s MLB Picks

The Cleveland Guardians and the Los Angeles Dodgers meet Wednesday in MLB action from Dodger Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cleveland Guardians vs. Los Angeles Dodgers prediction.

Starting Pitching Matchup

The Cleveland Guardians will start Gavin Williams here and Williams is 0-1 with a 5.40 ERA and 7 strikeouts this season. The Los Angeles Dodgers will send Yoshinobu Yamamoto for the start here and Yamamoto is 1-0 with a 3.00 ERA and 6 strikeouts this season. 

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to bounce back from a 4-1 loss at the hands of the Dodgers on Tuesday to drop to 3-3 this season. After this series, the Guardians will head home for a series with the Chicago Cubs.

Guardians Alternate Wins & Losses In 6 Straight

Steven Kwan leads the Guardians with 7 hits along with a double and a pair of RBIs while Chase DeLauter has 6 hits with 4 home runs and 5 RBIs. Daniel Schneeman and Jose Ramirez each have 3 hits with 2 doubles with Ramirez logging 3 RBIs while Schneemann has 2 RBIs. Rhys Hoskins also has 4 hits with a pair of doubles as well this season. 

Los Angeles Dodgers Recap

The Los Angeles Dodgers come into this game looking to add on to Tuesday’s win over Cleveland to sit at 4-1 this season. After this series, the Dodgers will head on the road for a series against the Washington Nationals.

Dodgers Rebound From First Loss

Andy Pages has a team-high 6 hits with a home run and 5 RBIs while Wil Smith has 2 home runs and 5 RBIs as well this season. Mookie Betts has 3 hits with a home run and 5 RBIs as well while Freddie Freeman, Miguel Rojas and Kyle Tucker each have 4 hits with a double. Max Muncy and Teoscar Hernandez each have 4 hits as well this season.

Cleveland Guardians @ Los Angeles Dodgers Betting Trends: April 1, 2026

• Probable Starting Pitcher: Yoshinobu Yamamoto      Record this season: 1-0      ERA: 3.00
• Home Record: 1-0
• Last 5 against Guardians: 1-0

Why the Los Angeles Dodgers will win

• The Dodgers have won each of their last 15 night games after playing the previous day.
• The Guardians have lost six of their last eight games against National League opponents.
• The Guardians have failed to cover the run line in four of their last five night games against teams that held a winning record.
• The Dodgers have covered the run line in three of their last four home games against the Guardians.
• The Dodgers have led after 5 innings in six of their last seven games against the Guardians.

• Probable Starting Pitcher: Gavin Williams      Record this season: 0-1      ERA: 5.40
• Road Record: 0-1
• Last 5 against Dodgers: 0-3

Why the Cleveland Guardians will win

• The Guardians have won each of their last six games as underdogs following a loss.
• The Dodgers have lost each of their last four games as favorites against American League opponents following a home win.
• The Guardians have covered the run line in each of their last 15 Wednesday games as underdogs.
• The Dodgers have failed to cover the run line in seven of their last eight games following a win.
• The Guardians have led after 3 innings in each of their last eight Wednesday road games.
• The Guardians have led after 5 innings in eight of their last nine Wednesday night games against opponents that held a winning record.

Total Runs Facts

• Nine of the Guardians’ last 10 road games against NL West opponents have gone UNDER the total runs line.
• Five of the Dodgers’ last six games against AL Central opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Dodgers’ last nine Wednesday games against American League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Guardians’ last six night games against National League opponents.

Los Angeles Dodgers Player Prop Facts

• Shohei Ohtani has hit a home run in three of the Dodgers’ last five games against AL Central opponents.
• Kyle Tucker has recorded at least one hit in 16 of his last 17 appearances at UNIQLO Field at Dodger Stadium.

Cleveland Guardians Player Prop Facts

• Rhys Hoskins has hit a home run in three of his last six road appearances against the Dodgers after playing the previous day.
• Steven Kwan has recorded at least one hit in each of the Guardians’ last 12 Wednesday games.
• Jose Ramirez ranks T5th in the league in Steals (2) this season.

Matchup/League Facts

• The Dodgers rank 2nd in the league for strikeouts against this season (32).
• The Dodgers rank 2nd in the league for opponent batting average this season (.189).
• The Guardians rank T2nd in the league for doubles this season (11).
• The Guardians rank 28th in the league for batting average this season (.188).

Cleveland Guardians vs. Los Angeles Dodgers Prediction

I’m on the Dodgers here. Just like Tuesday with Ohtani, I think Yamamoto gives the Dodgers a massive edge in starting pitching in this matchup, with Gavin Williams not looking great in his debut and now up against a Dodger lineup that’s just far too powerful for Williams to compete with here. I think the Dodgers get a comfortable win here so give me Los Angeles.

Chris Ruffolo's Pick: Los Angeles Dodgers -235