Cleveland Guardians vs Houston Astros Prediction 6/21/2026 Today’s MLB Picks

The Cleveland Guardians and the Houston Astros meet Sunday in MLB action from Daikin Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cleveland Guardians vs. Houston Astros prediction.

Starting Pitching Matchup

The Cleveland Guardians will send out Slade Cecconi for the start here and Cecconi is 3-5 with a 4.60 ERA and 65 strikeouts this season. Kai-Wei Teng will start for Houston here and is 3-6 with a 4.31 ERA and 58 strikeouts this season. 

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to add on to their 8-1 win over Houston last time out to sit at 41-36 this season. After this series, the Guardians will head on the road for a series against the Chicago White Sox.

Guardians Alternate Wins & Losses In 4 Straight

Chase DeLauter has 63 hits with 12 doubles, 7 home runs and 34 RBIs while Steven Kwan has 50 hits with 8 doubles, a home run and 13 RBIs and Jose Ramirez has 64 hits with 18 doubles, 10 home runs and 33 RBIs this season. Brayan Rocchio has also added 63 hits with 10 doubles, 5 home runs and 32 RBIs this season while Angel Martinez has 54 hits with 11 doubles, 11 homers and 33 RBIs and Rhys Hoskins has added 30 hits with 12 doubles, 6 home runs and 24 RBIs. Daniel Schneemann has 42 hits with 9 doubles, 6 home runs and 26 RBIs this season. 

Houston Astros Recap

The Houston Astros come into this game looking to shake off their loss at the hands the Guardians from Saturday to sit at 36-42 this season. After this series, the Astros will head on the road for a series against the Toronto Blue Jays.

Astros Have Three-Game Win Streak Snapped

Yordan Alvarez has 89 hits with 15 doubles, 24 home runs and 55 RBIs while Christian Walker has 69 hits with 14 doubles, 18 home runs and 52 RBIs on the year. Jose Altuve’s chipped in 46 hits with 10 doubles, 7 home runs and 16 RBIs and Isaac Paredes has 57 hits with 14 doubles, 10 home runs and 36 RBIs. Cam Smith also has 56 hits with 12 doubles, 7 home runs and 26 RBIs.

Cleveland Guardians @ Houston Astros Betting Trends: June 21, 2026

• Probable Starting Pitcher: Kai-Wei Teng      Record this season: 3-6      ERA: 4.31
• Home Record: 2-3
• Last 5 against Guardians: 0-0

Why the Houston Astros will win

• The Guardians have lost each of their last four road games following a win.
• The Astros have won each of their last four games following a home loss.
• The Astros have covered the run line in each of their last four home games against American League opponents following a home loss.
• The Guardians have failed to cover the run line in each of their last six Sunday games against AL West opponents.
• The Astros have led after 5 innings in four of their last five day games against opponents that held a winning record.
• The Guardians have trailed after 3 innings in four of their last five day games against AL West opponents.
• The Guardians have lost the first inning in each of their last three day games against opponents that held a losing record.

• Probable Starting Pitcher: Slade Cecconi      Record this season: 3-5      ERA: 4.60
• Road Record: 3-4
• Last 5 against Astros: 1-1

Why the Cleveland Guardians will win

• The Guardians have won four of their last five games as underdogs against the Astros.
• The Astros have lost five of their last six games as home favorites following a loss.
• The Guardians have covered the run line in each of their last nine Sunday day games against the Astros.
• The Astros have failed to cover the run line in 10 of their last 11 games as favorites following a loss.
• The Astros have trailed after 3 innings in seven of their last eight games as favorites against AL Central opponents.
• The Guardians have won the first inning in three of their last four games at Daikin Park.
• The Guardians have led after 5 innings in seven of their last eight games against opponents that held a losing record.

Total Runs Facts

• Seven of the Astros’ last eight day games against AL Central opponents have gone UNDER the total runs line.
• Six of the Guardians’ last seven games as underdogs against AL West opponents have gone OVER the total runs line.
• There has been at least one run scored in the first inning in each of the last seven games between the Guardians and Astros.
• There has been no run scored during the first inning in seven of the Guardians’ last eight day games at Daikin Park.

Houston Astros Player Prop Facts

• Christian Walker has hit at least one home run in three of the Astros’ last four day games against opponents that held a winning record.
• Yainer Diaz has recorded at least one hit in each of his last nine appearances against opponents that held a winning record.
• Yordan Alvarez ranks 1st amongst qualified players for Slugging Percentage (.630) this season.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit a home run in each of his last four appearances with the Guardians as underdogs against the Astros.
• Jose Ramirez has recorded at least one hit in each of his last 10 appearances against the Astros.

Matchup/League Facts

• The Astros rank 30th in the league for steals this season (24).
• The Astros rank 29th in the league for triples this season (5).
• The Guardians rank 29th in the league for slugging percentage this season (.372).
• The Guardians rank 28th in the league for hits this season (579).

Cleveland Guardians vs. Houston Astros Prediction

I’m on Cleveland in this one. I’m still not sold on Kai-Wei Teng and I feel like the Guardians are still a better team than what they’ve shown in some of their recent outings. Teng continues to be hit or miss and while the Astros have been playing some decent baseball as of late I still think the Guardians can get the job done and win the rubber match here. Give me Cleveland.

Chris Ruffolo's Pick: Cleveland +125