Cleveland Guardians vs Detroit Tigers Prediction 5/24/25 MLB Picks

The Cleveland Guardians are visiting Detroit Tigers on Saturday, May 24th at the Comerica Park in the third game of this series, with the Guardians having a 2-0 lead. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cleveland Guardians vs Detroit Tigers Prediction. We will examine:

The Detroit Tigers recent form and player performance

The Cleveland Guardians recent form and player performance

Recent betting trends and streaks involving the Detroit Tigers

Recent betting trends and streaks involving the Cleveland Guardians

Recent betting trends in games played between the Cleveland Guardians vs Detroit Tigers

A summary that ties it all together and produces a favorable betting outcome for A Cleveland Guardians vs Detroit Tigers game

Detroit Tigers Preview

The Detroit Tigers have a 33-19 record this season and are sitting on the first place of the AL Central. The Tigers have a 17-7 home record and are 25-22 in over/under. They are coming off a 1-3 home defeat by the Guardians, and have back-to-back losses. Under is 3-0 in their last 3 games and are playing the Royals and the Giants next.

The Tigers have a .255 batting average this season, .327 OBP and .415 slugging percentage. Detroit’s pitching staff has a 3.35 ERA and 1.18 WHIP. Riley Greene leads the Tigers with 54 hits, while Spencer Torkelson leads the team in RBI, with 40, and in home runs with 13. Kerry Carpenter is the team’s best hitter with a .280 batting average.

Casey Mize (R) will take the mound for the Tigers, and he has a 6-0 record, 2.53 ERA and 1.01 WHIP. He has been better at home with a 1.47 ERA across three home starts, and he has given up one run in three of his last four starts. In his only start against the Guardians back in 2020, he gave up 3 runs in 3.2 innings of work.

Cleveland Guardians Preview

The Cleveland Guardians have a 28-22 record this season and are sitting on the second place of the AL Central. The Guardians have a 14-14 road record and are 23-24 in over/under They are coming off a 3-1 road victory over the Tigers, and have three consecutive wins. Under is 8-2 in their last 10 games, and are playing the Dodgers and the Angels next.

The Guardians have a .233 batting average this season, .307 OBP and .381 Slugging percentage. Cleveland’s pitching staff has a 3.97 ERA and 1.39 WHIP. Steven Kwan leads the Guardians with 64 hits and a team-high .322 batting average. Carlos Santana adds a team-high 27 RBI and Kyle Manzardo adds a team-high 10 home runs.

Luis Ortiz (R) will take the mound for the Guardians, and he has a 2-5 record, 4.66 ERA and 1.39 WHIP. He has been weaker on the road with a 6.58 ERA across five road starts, and he has given up 3 runs in 11 innings of work across his last two starts. In his only start against the Tigers back in 2023, he gave up 3 runs in 3 innings of work.  

Why the Detroit Tigers will win

• The Guardians have lost each of their last six Saturday night games against teams that held a winning record.
• The Tigers have won five of their last six night games at Comerica Park following a loss.
• The Tigers have covered the run line in 12 of their last 14 night games against AL Central opponents.
• The Guardians have failed to cover the run line in seven of their last eight Saturday night games.
• The Guardians have trailed after 5 innings in six of their last eight games as road underdogs against American League opponents.
• The Guardians have trailed after 3 innings in six of their last eight games as road underdogs against American League opponents.

Why the Cleveland Guardians will win

• The Guardians have won each of their last six games as underdogs following a road win.
• The Tigers have lost each of their last four games as favorites against AL Central opponents following a home loss.
• The Tigers have failed to cover the run line in each of their last nine games as favorites.
• The Guardians have covered the run line in each of their last 10 Saturday games as underdogs against AL Central opponents.
• The Guardians have won the first inning in three of their last four night games at Comerica Park.
• The Tigers have trailed after 5 innings in four of their last five night games against opponents that held a winning record.

Total Runs Facts

• Each of the Guardians’ last six night games after playing the previous day have gone UNDER the total runs line.
• Each of the Tigers’ last four games against American League opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 11 of the Guardians’ last 13 night games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Tigers’ last six night games at Comerica Park.

Matchup/League Facts

• The Tigers rank 30th in the league for steals this season (20).
• The Tigers rank 4th in the league for runs scored this season (268).
• The Guardians rank 25th in the league for hits this season (379).
• The Guardians rank 25th in the league for doubles this season (68).

Cleveland Guardians vs Detroit Tigers Prediction

The Guardians are 7-2 in their last 9 overall meetings against the Tigers, and 5-1 in their last 6 visits in Detroit. Under is 6-3-1 in their last 10 meetings.  

In this Cleveland Guardians vs Detroit Tigers Prediction, the Tigers are coming as -150 home favorites. The Tigers are rightfully favored, as they have a better overall record this season, and have been extremely strong at home, while the Guardians are mediocre on the road. the Tigers have a better bullpen, a better batting average and the advantage on the mound. This is a perfect bounce-back spot, as they have lost the previous two games at home by the Guardians. Take the Detroit Tigers on the moneyline.