Cleveland Guardians vs Detroit Tigers Prediction 9/18/2025 Today’s MLB Picks

The Cleveland Guardians and Detroit Tigers meet on Thursday in MLB action from Comerica Park. Here’s a Cleveland Guardians vs Detroit Tigers prediction. We will look at this from a betting perspective and determine the best Tigers vs Guardians pick. We will examine:

The Cleveland Guardians’ recent form and player performance

The Detroit Tigers’ recent form and player performance

Recent betting trends and streaks involving the Guardians

Recent betting trends and streaks involving the Tigers 

Recent betting trends in games played between the Guardians vs Tigers

A summary that ties it all together and produces a favorable betting outcome for the Guardians vs Tigers game.

Guardians Are Trying to Make a Run for It

The Guardians are trying to make a run for it, and they are currently only 2.5 games behind the Seattle Mariners for the last wild card spot. On Wednesday, the Guardians finished with four runs and seven hits, and that was enough for the victory. Jose Ramirez finished the game with three walks and one run. Bo Naylor also had a big time hit that drove in two runs. Gavin Williams went five innings giving up three hits and zero runs. The bullpen then came in and closed the deal. 

The Guardians are averaging 3.91 runs while their pitching is giving up 4.08 runs per game. The offense is ranked 27th in baseball, and when they look back on this season, it will be regret over the offense not getting enough quality hits. Jose Ramirez has hit 28 home runs and driven in 78 RBIs so far this season. Getting the start for Cleveland will be Tanner Bibee and he sits with a 10-11 record and an ERA of 4.44. His last start was a complete game shutout against the Chicago White Sox. 

Why the Guardians Will Beat the Tigers

The Guardians have won each of their last five games as road underdogs against American League opponents.
The Tigers have lost five of their last six games as home favorites.
The Guardians have covered the run line in each of their last six games as underdogs against American League opponents.
The Tigers have failed to cover the run line in five of their last six games as favorites.
The Tigers have trailed after 5 innings in each of their last three games against American League opponents.

Tigers are Suddenly Struggling 

The Tigers are suddenly struggling heading into this game and they have lost two games in a row. In the first game of the series the pitching let them down, and on Wednesday, it was the offense that let them down. Colt Keith was the top offensive player finishing with a hit and a walk. Jack Flaherty got the start and he went five innings, giving up three hits and one run. He had four strikeouts and four walks. 

The Tigers are averaging 4.83 runs while their pitching is giving up 4.24 runs per game. The offense is ranked 9th in the league while the pitching is ranked 13th. As a team they are batting .248 which is 15th. Getting the start for the Tigers will be Tarik Skubal who sits with a 13-5 record and an ERA of 2.26. He left his last start against the Marlins with an injury but he evidently is healthy enough to go in this game. 

Why the Tigers Will Beat The Guardians

The Guardians have lost seven of their last eight day games against American League opponents that held a winning record.
The Tigers have won 10 of their last 12 games against AL Central opponents following a loss.
The Guardians have failed to cover the run line in each of their last six day games against AL Central opponents following a win.
The Tigers have covered the run line in six of their last seven day games against the Guardians at Comerica Park following a loss.
The Guardians have trailed after 5 innings in five of their last six day games at Comerica Park against American League opponents.

Cleveland Guardians vs Detroit Tigers Prediction 

The Tigers are big favorites here, but they aren’t the play. I am not so sold that Skubal is actually healthy and when he gives up a couple of runs early, he’s going to be shutout. Bibee in his last start was dominant, and he’s going to really step up again. The Tigers bats were ice cold on Wednesday, and they are going to be ice cold again here. There is just not a world where you should be laying this type of number with the Tigers here. Back the Guardians to pull off the big upset, and get closer in the playoff race. 

Shane Mickle's Pick: Guardians ML +175