Cleveland Guardians vs Arizona Diamondbacks Prediction 8/19/2025 Today’s MLB Picks

The Cleveland Guardians and Arizona Diamondbacks meet Tuesday in MLB action at Chase Field. Here’s a Cleveland Guardians vs Arizona Diamondbacks Prediction. This article will include a Cleveland Guardians vs Arizona Diamondbacks Pick.

Cleveland Guardians Betting Preview

The Cleveland Guardians are 64-60 on the year and play the Rangers, Rays, and Mariners next. The Cleveland Guardians are batting .227 on the season, have a .299 OBP, and a .375 slugging percentage. The Cleveland Guardians pitching staff has a 3.86 ERA and a 1.31 WHIP. Jose Ramirez leads the Cleveland Guardians with 133 hits and 64 RBI, while Steven Kwan and Carlos Santana have combined for 219 hits and 91 RBI. 

Tanner Bibee gets the ball for the Cleveland Guardians, and he is 9-9 with a 4.54 ERA and 124 strikeouts this season. This will be Bibee’s second career game against the Arizona Diamondbacks.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks are 60-66 on the year and play the Reds, Brewers, and Dodgers next. The Arizona Diamondbacks are batting .250 on the season, have a .326 OBP, and a .439 slugging percentage. The Arizona Diamondbacks pitching staff has a 4.57 ERA and a 1.34 WHIP. Geraldo Perdomo leads the Arizona Diamondbacks with 130 hits and 79 RBI while Lourdes Gurriel Jr. and Corbin Carroll have combined for 220 hits and 130 RBI.

Eduardo Rodriguez gets the ball for the Arizona Diamondbacks, and he is 5-7 with a 5.40 ERA and 111 strikeouts this season. Rodriguez is 7-0 with a 2.51 ERA and 47 strikeouts in his career against the Cleveland Guardians.

Why the Arizona Diamondbacks will win

• The Guardians have lost seven of their last eight games against NL West opponents following a road win.
• The Diamondbacks have won seven of their last eight Tuesday night home games against American League opponents.
• The Diamondbacks have covered the run line in each of their last six Tuesday night games as favorites against American League opponents.
• The Guardians have failed to cover the run line in five of their last six night games against NL West opponents following a road win.

Why the Cleveland Guardians will win

• The Guardians have won each of their last 16 Tuesday night games against teams that held a losing record.
• The Diamondbacks have lost each of their last four games as favorites against American League opponents.
• The Guardians have covered the run line in each of their last seven games as underdogs against National League opponents following a road win.
• The Diamondbacks have failed to cover the run line in each of their last five home games against American League opponents.
• The Diamondbacks have trailed after 3 innings in each of their last three home games against AL Central opponents that held a winning record.
• The Guardians have led after 5 innings in four of their last five road games.

Arizona Diamondbacks Player Prop Facts

• Geraldo Perdomo has hit a home run in three of the Diamondbacks’ last five games against AL opponents that held a winning record.
• Eduardo Rodriguez has recorded five or more strikeouts in each of his last seven appearances with his team as a favorite against AL Central opponents.
• Geraldo Perdomo has recorded at least one hit in each of the Diamondbacks’ last nine home games.
• Eduardo Rodriguez has recorded a win in five of his last six appearances with his team as a favorite against AL Central opponents .
• Ketel Marte ranks 6th amongst qualified players for Slugging Percentage (.553) this season.

Cleveland Guardians Player Prop Facts

• Brayan Rocchio has hit a home run in each of the Guardians’ last two night games against NL opponents that held a losing record.
• Carlos Santana has recorded at least one hit in seven of his last eight appearances against NL West opponents.
• Carlos Santana has recorded a Double in three of his last four appearances in night games against NL West teams that held a losing record.

Cleveland Guardians vs Arizona Diamondbacks Prediction

The Guardians have won seven straight games Bibee has pitched, but he’s been hittable all season, especially on the road where he has a 5.59 ERA and .268 allowed batting average. Rodriguez hasn’t been good this season, but he’s owned the Guardians throughout his career, which includes holding current hitters to a .240 batting average and .287 on base percentage in 75 at bats. The Diamondbacks are due for a bounce back win. Give me Arizona on Tuesday.