Cincinnati Reds vs Seattle Mariners Prediction 7/22/2026 Today’s MLB Picks

In this article, we will formulate a Reds vs Mariners Prediction for this MLB matchup on Wednesday, July 22nd in the third game of this series. Let’s take a look at the prediction for this MLB matchup.

Seattle Mariners Preview

The Seattle Mariners have a 51-51 record this season and are sitting in the 2nd place of the AL West. They have a 30-22 home record and are coming off a 2-4 home loss against the Reds. They will face the Rangers and the Dodgers next.

The Seattle Mariners have a .230 batting average this season, .310 OBP and .378 Slugging percentage. Seattle’s pitching staff has a 3.57 ERA and 1.17 WHIP. Randy Arozarena is the team’s best hitter with a .282 batting average. Cole Young leads the team in RBI with 48, while Luke Raley adds a team-high 15 home runs.

Emerson Hancock (R) is the projected starting pitcher for the Seattle Mariners, and he has a 6-4 record, 3.17 ERA and 1.01 WHIP.

Cincinnati Reds Preview

The Cincinnati Reds have a 46-54 record this season and are sitting in the 5th place of the NL Central. They have a 24-26 away record and are coming off a 4-2 road win against the Mariners. They will face the Cardinals and the Guardians next.

The Cincinnati Reds have a .230 batting average this season, .310 OBP and .399 Slugging percentage. Cincinnati’s pitching staff has a 4.60 ERA and 1.44 WHIP. Elly De La Cruz is the team’s best hitter with a .280 batting average. Sal Stewart leads the team in RBI with 71, adding a team-high 20 home runs.

Brady Singer (R) is the projected starting pitcher for the Cincinnati Reds, and he has a 4-9 record, 4.56 ERA and 1.41 WHIP.

Cincinnati Reds @ Seattle Mariners Betting Trends: July 22, 2026

• Probable Starting Pitcher: Emerson Hancock      Record this season: 6-4      ERA: 3.17
• Home Record: 3-2
• Last 5 against Reds: 0-0

Why the Seattle Mariners will win

• The Reds have lost each of their last seven games following a win.
• The Mariners have won eight of their last nine home games following a loss.
• The Mariners have covered the run line each of their last seven day games against teams that held a losing record.
• The Reds have failed to cover the run line in each of their last four games following a road win.
• The Reds have lost the first inning in each of their last five Wednesday road games.
• The Mariners have led after 5 innings in four of their last five home day games.
• The Mariners have led after 3 innings in 13 of their last 17 day games against opponents that held a losing record.

• Probable Starting Pitcher: Brady Singer      Record this season: 4-9      ERA: 4.56
• Road Record: 1-5
• Last 5 against Mariners: 1-2

Why the Cincinnati Reds will win

• The Mariners have lost four of their last five games as favorites against National League opponents following a loss.
• The Reds have won three of their last four games as road underdogs.
• The Mariners have failed to cover the run line in seven of their last eight day games against National League opponents.
• The Reds have covered the run line in five of their last six day games against American League opponents.
• The Reds have won the first inning in three of their last four games as road underdogs.
• The Reds have led after 5 innings in six of their last seven day games against American League opponents.
• The Mariners have trailed after 3 innings in five of their last six games as favorites against NL Central opponents.

Total Runs Facts

• Six of the Reds’ last seven day games after playing the previous day have gone OVER the total runs line.
• Four of the Mariners’ last five games as favorites against NL Central opponents have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in eight of the Reds’ last nine road games.
• There has been no run scored during the first inning in 14 of the Mariners’ last 16 games.

Seattle Mariners Player Prop Facts

• Cal Raleigh has hit at least one home run in three of the Mariners’ last four games against the Reds.
• Emerson Hancock has recorded six or more strikeouts in each of his last three home appearances against NL opponents.
• Josh Naylor has recorded at least one hit in each of his last 17 home appearances against NL Central opponents that held a losing record.
• Josh Naylor ranks T10th in the league in Steals (20) this season.

Cincinnati Reds Player Prop Facts

• Brady Singer has recorded six or more strikeouts in each of his last five appearances against the Mariners.
• Sal Stewart has recorded at least one hit in each of the Reds’ last eight Wednesday games.
• Nathaniel Lowe has hit a home run in three of his last four appearances.
• Elly De La Cruz is one of only seven players to record 10+ Home Runs and 4+ Triples this season.

Matchup/League Facts

• The Mariners rank 30th in the league for doubles this season (123).
• The Mariners rank 30th in the league for doubles this season (123).
• The Reds rank 29th in the league for hits this season (769).
• The Reds rank 29th in the league for hits this season (769).

Reds vs Mariners Prediction

The Mariners are 7-2 in their last 9 meetings against the Reds and are 4-1 in their last 5 meetings in Seattle.

In this Reds vs Mariners Prediction, the Mariners are coming as -150 home favorites. I like the Mariners in a bounce-back spot at home today, as they have the pitching edge with Hancock going up against Brady Singer. Hancock has been unhittable lately with a 0.63 ERA across his last three starts and a solid 2.92 home ERA, while Singer has been terrible on the road with a 1-5 record and 6.14 ERA. On top of that, the Mariners have a better bullpen and are much better against right-handed pitching, so I expect them to get the job done at home in this one.

Nikos Lagouretos's Pick: Seattle Mariners ML