Cincinnati Reds vs Pittsburgh Pirates Prediction 5/19/25 MLB Picks

The Cincinnati Reds and Pittsburgh Pirates meet Monday in MLB action at PNC Park. Here’s a Cincinnati Reds vs Pittsburgh Pirates Prediction. This article will include a Cincinnati Reds vs Pittsburgh Pirates Pick.

Cincinnati Reds Betting Preview

The Cincinnati Reds are 24-24 on the year and play the Cubs, Royals, and Cubs next. The Cincinnati Reds are batting .243 on the season, have a .320 OBP, and a .395 slugging percentage. The Cincinnati Reds pitching staff has a 3.58 ERA and a 1.17 WHIP. Elly De La Cruz leads the Cincinnati Reds with 46 hits and 31 RBI, while TJ Friedl and Gavin Lux have combined for 87 hits and 36 RBI. 

Nick Lodolo gets the ball for the Cincinnati Reds, and he is 3-4 with a 3.42 ERA and 42 strikeouts this season. Lodolo is 2-2 with a 4.30 ERA and 37 strikeouts in his career against the Pittsburgh Pirates.

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 15-32 on the year and play the Brewers, Diamondbacks, and Padres next. The Pittsburgh Pirates are batting .217 on the season, have a .297 OBP, and a .322 slugging percentage. The Pittsburgh Pirates’ pitching staff has a 4.08 ERA and a 1.27 WHIP. Ke’Bryan Hayes leads the Pittsburgh Pirates with 41 hits and 15 RBI, while Bryan Reynolds and Isiah Kiner-Falefa have combined for 71 hits and 30 RBI.

Mitch Keller gets the ball for the Pittsburgh Pirates, and he is 1-5 with a 4.15 ERA and 43 strikeouts this season. Keller is 3-5 with a 6.06 ERA and 78 strikeouts in his career against the Cincinnati Reds.

Why the Pittsburgh Pirates will win

• The Pirates have won each of their last five games as home underdogs against the Reds following a loss.
• The Reds have lost each of their last four games as road favorites against the Pirates following a win.
• The Pirates have covered the run line in seven of their last eight home games following a road loss.
• The Reds have failed to cover the run line in seven of their last eight games as road favorites against National League opponents following a home win.
• The Reds have trailed after 3 innings in three of their last four road games against NL Central opponents that held a losing record.

Why the Cincinnati Reds will win

• The Pirates have lost each of their last five games against NL Central opponents following a road loss.
• The Reds have won each of their last four games after playing the previous day.
• The Reds have covered the run line in eight of their last nine night games against NL Central opponents that held a losing record.
• The Pirates have failed to cover the run line in each of their last five games against NL Central opponents following a road loss.
• The Pirates have trailed after 5 innings in eight of their last 10 night games at PNC Park against NL Central opponents.

Pittsburgh Pirates Player Prop Facts

• Ke’Bryan Hayes has hit a home run in two of his last three home appearances against the Reds after playing the previous day.
• Joey Bart has recorded an RBI in three of the Pirates’ last four home games against the Reds.
• Andrew McCutchen has scored at least one run in 11 of his last 12 Monday appearances at PNC Park.
• Ke’Bryan Hayes has recorded at least one Single in 10 of his last 11 appearances with the Pirates as home underdogs.
• Oneil Cruz has recorded at least one hit in each of his last seven appearances against the Reds after playing the previous day.
• Mitch Keller has recorded six or more strikeouts in five of his last six appearances with the Pirates as home underdogs against NL Central opponents.

Cincinnati Reds Player Prop Facts

• Will Benson has hit at least one home run in each of the Reds’ last two games as favorites.
• Tyler Stephenson has recorded a Double in three of the Reds’ last four games as road favorites against the Pirates.
• Will Benson has scored at least one run in each of the Reds’ last four games.
• Elly De La Cruz has recorded at least one RBI in six of the Reds’ last seven games as road favorites against NL Central opponents.
• Nick Lodolo has recorded eight or more strikeouts in each of his four previous appearances against the Pirates.
• Elly De La Cruz has recorded at least one Single in each of the Reds’ last six games as road favorites against NL opponents.
• Elly De La Cruz has recorded at least one hit in each of the Reds’ last 10 games as road favorites against NL opponents.

Cincinnati Reds vs Pittsburgh Pirates Prediction

The Reds are playing their best ball of the season with four straight wins, and they should like their chances to keep things rolling against a bad Pirates side. The Pirates have won four games since April 26, and their offense has scored three or fewer runs in 11 of their last 14 games. In 31.1 road innings, Lodolo has a 1.44 ERA and .186 allowed batting average. In 27 home innings, Keller has a 5.33 ERA and a .279 allowed batting average. There’s no reason to look in the Pirates’ direction, especially with a line this soft. Give me the Reds.