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Cincinnati Reds vs Chicago Cubs Prediction 5/31/25 MLB Picks

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Chicago Cubs (35-22) vs Cincinnati Reds (29-29)

May 31, 2025 at 02:20 PM EDT

The Line: Betting Odds: Chicago Cubs +0.0001 / Cincinnati Reds +0.0001 — Over/Under: 0.0001

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In this article, we will formulate a Cincinnati Reds vs Chicago Cubs Prediction for this MLB game on Saturday, May 31st, at Wrigley Field. To formulate this prediction, we will look at: 

-The Reds’ recent form and recent player performance

-The Cubs’ recent form and recent player performance

-Recent Betting trends and streaks involving Cincinnati

-Recent Betting trends and streaks involving Chicago

-Recent betting trends in games played between Cincinnati and Chicago

-A summary that ties it all together produces a favorable betting outcome for Today’s Game between the Reds and Cubs. 

Big Series for the Reds

It is a big series for the Reds, and after moving back to .500 on Friday, they have a chance to make a statement with success the rest of this series. On Friday, Andrew Abbott was dominant, and he went seven innings, giving up one hit and zero runs. In this game, pitching is going to need to be a key again. 

The Reds are averaging 4.63 runs while their pitching is giving up 4.07 runs per game. The offense is ranked 9th while the pitching is ranked 13th. They do have a positive run differential of 0.56, which is 9th. Elly De La Cruz has hit 11 home runs and driven in 40 RBIs. Getting the start for the Cubs will be Nick Lodolo, who sits with a 4-4 record and an ERA of 4.39. Against the Cubs in his last start, he went five innings, giving up six hits and three runs. Two games ago against the Pittsburgh Pirates, he went six innings, giving up four hits and one run.

Disappointing Game for the Cubs

It was a disappointing game for the Cubs on Friday afternoon as the offense only scored two runs, while the pitching gave up 10 his and six runs. Colin Rea went 5.2 innings gviing up 10 hits and six runs. He had two walks, and as is often the case, the walks came back to haunt him. No one on the offense had more than one hit, 

The Cubs are averaging 5.89 runs while their pitching is giving up 4.19 runs per game. The offense is ranked 1st while the pitching is ranked 15th. They do have a positive run differential of 1.69 which is 2nd. Pete-Crow Armstrong has hit 15 home runs and driven in 50 RBIs so far this season. 

Why the Cubs Will Beat the Reds


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  • The Reds have lost 14 of their last 15 road games against NL Central opponents following a road win.
  • The Cubs have won seven of their last eight home games after playing the previous day.
  • The Reds have failed to cover the run line in each of their last five day games against the Cubs following a win.
  • The Cubs have covered the run line in each of their last four games against National League opponents following a loss.

Total Runs Facts

  • Thirteen of the Reds’ last 15 road games against NL Central opponents have gone UNDER the total runs line.
  • Each of the last four games between the Reds and Cubs at Wrigley Field have gone UNDER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in 12 of the Cubs’ last 13 games.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Reds’ last five day games.

Cincinnati Reds vs Chicago Cubs Prediction

The Cubs are the better team, and they are going to have no issue getting the job done in this game. Lodolo sits with a higher ERA of 4.39, and he gave up three runs in his last start against the Cubs. The Cubs’ offense is averaging 5.89 runs, and they are going to have no issue running up the score against Lodolo. The Reds’ offense won’t even get to their season average, and it’s going to be the Cubs are going to have no issue getting the job done. Back the Cubs on the money line. 

Shane Mickle's Pick: Chicago Cubs ML

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