Cincinnati Reds pitcher Lyon Richardson (72) pitches during a Major League Baseball game between the Atlanta Brave and Cincinnati Reds at Bristol Motor Speedway on August 3, 2025.

Cincinnati Reds vs Chicago Cubs Prediction 08/04/2025 Today’s MLB Picks

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Cincinnati (58-54) vs Chicago (65-46)

August 4, 2025 at 08:05 PM EDT

The Line: Betting Odds: Chicago 0.0001 — Over/Under: 0.0001

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The Cincinnati Reds and Chicago Cubs meet Monday in MLB action at Wrigley Field. Here’s a Cincinnati Reds vs Chicago Cubs Prediction. This article will include a Cincinnati Reds vs Chicago Cubs Pick.

Cincinnati Reds Betting Preview

The Cincinnati Reds are 58-54 on the year and play the Pirates, Phillies, and Brewers next. The Cincinnati Reds are batting .247 on the season, have a .321 OBP, and a .393 slugging percentage. The Cincinnati Reds pitching staff has a 3.89 ERA and a 1.24 WHIP. Elly De La Cruz leads the Cincinnati Reds with 121 hits and 72 RBI, while TJ Friedl and Spencer Steer have combined for 194 hits and 82 RBI. 

Nick Lodolo gets the ball for the Cincinnati Reds, and he is 8-6 with a 3.09 ERA and 123 strikeouts this season. Lodolo is 2-2 with a 4.46 ERA and 38 strikeouts in his career against the Chicago Cubs.

Chicago Cubs Betting Preview

The Chicago Cubs are 65-46 on the year and play the Cardinals, Blue Jays, and Pirates next. The Chicago Cubs are batting .255 on the season, have a .324 OBP, and a .441 slugging percentage. The Chicago Cubs pitching staff has a 3.92 ERA and a 1.23 WHIP. Nico Hoerner leads the Chicago Cubs with 120 hits and 46 RBI while Pete Crow-Armstrong and Kyle Tucker have combined for 225 hits and 139 RBI.

Michael Soroka gets the ball for the Chicago Cubs, and he is 3-8 with a 4.87 ERA and 87 strikeouts this season. Soroka is 1-2 with a 3.94 ERA and 17 strikeouts in his career against the Cincinnati Reds.

Why the Chicago Cubs will win

  • The Cubs have won each of their last six night games at Wrigley Field following a home win.
  • The Reds have lost four of their last five road games against NL Central opponents that held a winning record.
  • The favorites have covered the run line in four of the last five games between the Reds and Cubs at Wrigley Field.
  • The Reds have failed to cover the run line in each of their last three games.
  • The Reds have trailed after 5 innings in each of their last three games as underdogs against NL Central opponents.
  • The Reds have trailed after 3 innings in six of their last seven road night games.

Why the Cincinnati Reds will win

  • The Cubs have lost each of their last six Monday night games as favorites against NL Central opponents.
  • The Reds have won four of their last five Monday night games as underdogs against NL Central opponents.
  • The Cubs have failed to cover the run line in each of their last eight Monday games as favorites against NL Central opponents.
  • The Reds have covered the run line in five of their last six games against National League opponents that held a winning record.

Chicago Cubs Player Prop Facts

  • Nico Hoerner has recorded at least one hit in each of the Cubs’ last 12 night games against opponents that held a winning record.
  • Michael Soroka has recorded six or more strikeouts in four of his last five appearances with his team as a home favorite.
  • Carson Kelly has hit a home run in each of his last two home appearances against NL opponents that held a winning record.
  • Seiya Suzuki has recorded a Double in five of the Cubs’ last six games as favorites against the Reds.

Cincinnati Reds Player Prop Facts

  • Elly De La Cruz has recorded at least one hit in each of the Reds’ last 11 night games against opponents that held a winning record.
  • Nick Lodolo has recorded five or more strikeouts in each of his last eight road appearances.
  • Elly De La Cruz has hit a home run in two of the Reds’ last three games as road underdogs against NL Central opponents.
  • Nick Lodolo has recorded a win in three of his last four appearances against NL opponents.
  • Jose Trevino has recorded at least one Double in each of his last three appearances against NL Central opponents that held a winning record.

Cincinnati Reds vs Chicago Cubs Prediction

The Cubs are probably going to get the benefit of the doubt because they’re at home, but Soroka has allowed 22 hits and 13 runs in his last 22 innings. Soroka has also seen his team lose in each of his last nine games. The Cubs haven’t won a game with Soroka on the mound since June 6. Lodolo has allowed 21 hits and seven runs in his last 33.1 innings. Lodolo has allowed nine runs in his last 43 innings. Absolutely dealing, folks. I’ll roll with the Reds on Monday.

Randy Chambers's Pick: Cincinnati Reds

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