Cincinnati Reds vs Arizona Diamondbacks Prediction 8/22/2025 Today’s MLB Picks

In this article, we will formulate a Reds vs Diamondbacks Prediction for this MLB game on Friday, August 22nd at the Chase Field in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 62-66 record this season and are sitting on the third place of the NL West. The Diamondbacks have a 32-31 home record and are 60-60 in over/under They are coming off a 3-2 home victory over the Guardians, and have back-to-back wins. Under is 5-2 in their last 7 games and are playing the Brewers and the Dodgers next.

The Diamondbacks have a .251 batting average this season, .325 OBP and .439 slugging percentage. Arizona’s pitching staff has a 4.55 ERA and 1.33 WHIP. Geraldo Perdomo leads the Diamondbacks with 134 hits, adding a team-high 81 RBI. Ketel Marte is the team’s best hitter with a .293 batting average. Corbin Carroll leads the team in home runs with 27.

Ryne Nelson (R) is the projected starting pitcher for the Diamondbacks, and he has a 6-3 record, 3.58 ERA and 1.07 WHIP.

Cincinnati Reds Preview

The Cincinnati Reds have a 67-61 record this season and are sitting in the third place of the NL Central. The Reds have a 31-32 road record and are 46-75 in over/under. They are coming off a 1-2 road defeat by the Angels, and saw their three-game winning streak getting snapped. Under is 3-1 in their last 4 games are playing the Cardinals and the Dodgers next.

The Reds have a .248 batting average this season, .318 OBP and .392 slugging percentage. Cincinnati’s pitching staff has a 3.79 ERA and 1.23 WHIP. Elly De La Cruz leads the Reds with 135 hits, and in RBI, with 76, adding a team-high 19 home runs. Gavin Lux is the team’s best hitter with a .280 batting average.

Zack Littell (R) is the projected starting pitcher for the Reds, and he has a 9-8 record, 3.52 ERA and 1.11 WHIP.

Why the Arizona Diamondbacks will win

• The Reds have lost seven of their last eight night games against National League opponents following a road loss.
• The Diamondbacks have won each of their last five home games against NL Central opponents that held a winning record.
• The Reds have failed to cover the run line in each of their last eight night games against National League opponents following a road loss.
• The Diamondbacks have covered the run line each of their last five games against NL Central opponents that held a winning record.
• The Diamondbacks have won the first inning in each of their last eight home games against National League opponents.
• The Diamondbacks have led after 5 innings in each of their last nine home games against National League opponents.
• The Diamondbacks have led after 3 innings in 10 of their last 11 games against the Reds.

Why the Cincinnati Reds will win

• The Reds have won each of their last six road games against NL West opponents that held a losing record.
• The Diamondbacks have lost five of their last six games as favorites after going to extra innings.
• The underdogs have covered the run line in each of the last eight games between the Reds and Diamondbacks.
• The Diamondbacks have failed to cover the run line in each of their last six night games against NL Central opponents following a home win.
• The Reds have led after 3 innings in three of their last four road games.
• The Diamondbacks have trailed after 5 innings in four of their last five games against opponents that held a winning record.

Total Runs Facts

• Each of the Diamondbacks’ last four games against NL Central opponents have gone UNDER the total runs line.
• Six of the Reds’ last seven games against NL West opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Diamondbacks’ last eight home games against National League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 15 of the Reds’ last 16 games at Chase Field.

Matchup/League Facts

• The Diamondbacks rank 2nd in the league for triples this season (31).
• The Diamondbacks rank T3rd in the league for RBIs this season (613).
• The Reds are one of only five teams in the league to rank top 10 in both ERA and hits allowed this season.
• The Reds rank 6th in the league for opponent batting average this season (.234).

Reds vs Diamondbacks Prediction

The Reds have won their last three meetings against the Dbacks, but Arizona is 6-1 in their seven meetings prior to that. The Dbacks are 3-1 in their 4 meetings in Arizona. Under is 7-2-1 in their last 10 meetings.

In this Reds vs Diamondbacks Prediction, the Diamondbacks are coming as -135 home favorites. Both pitchers have been excellent this season, with a combined 7.10 ERA, and Nelson has been even better at home for Arizona, with a 2.20 home ERA. Littell has been in excellent form lately, having one run or less in three of his last four starts, and most of their recent meetings between those two teams have been low scoring ones. Take the under 9 in this one.