Chicago White Sox vs Washington Nationals Prediction 9/28/2025 Today’s MLB Picks

The Chicago White Sox and Washington Nationals meet Sunday in MLB action at Nationals Park. Here’s a Chicago White Sox vs Washington Nationals Prediction. This article will include a Chicago White Sox vs Washington Nationals Pick.

Chicago White Sox Betting Preview

The Chicago White Sox are 59-102 on the year after playing the Yankees. The Chicago White Sox are batting .232 on the season, have a .301 OBP, and a .372 slugging percentage. The Chicago White Sox pitching staff has a 4.30 ERA and a 1.37 WHIP. Lenyn Sosa leads the Chicago White Sox with 135 hits and 75 RBI, while Miguel Vargas and Chase Meidroth have combined for 231 hits and 81 RBI.

Shane Smith gets the ball for the Chicago White Sox, and he is 6-8 with a 3.98 ERA and 137 strikeouts this season. This will be Smith’s first career game against the Washington Nationals.

Washington Nationals Betting Preview

The Washington Nationals are 66-95 on the year after playing the Braves. The Washington Nationals are batting .243 on the season, have a .306 OBP, and a .391 slugging percentage. The Washington Nationals pitching staff has a 5.33 ERA and a 1.45 WHIP. James Wood leads the Washington Nationals with 153 hits and 94 RBI, while CJ Abrams and Luis Garcia Jr. have combined for 272 hits and 126 RBI.

Brad Lord gets the ball for the Washington Nationals, and he is 5-9 with a 4.12 ERA and 104 strikeouts this season. This will be Lord’s first career game against the Chicago White Sox.

The Chicago White Sox @ Washington Nationals Betting Trends: September 28, 2025

• Probable Starting Pitcher: Brad Lord       Record this season: 5-9      ERA: 4.12
• Home Record: 1-4
• Last 5 against White Sox: –

Why the Washington Nationals will win

• The White Sox have lost seven of their last eight road games.
• The Nationals have won each of their last seven Sunday home games against AL Central opponents.
• The Nationals have covered the run line in seven of their last eight day games against AL Central opponents following a home win.
• The White Sox have failed to cover the run line in four of their last five games against teams that held a losing record.
• The White Sox have trailed after 5 innings in seven of their last nine games as road underdogs.

• Probable Starting Pitcher: Shane Smith      Record this season: 6-8      ERA: 3.98
• Road Record: 3-4
• Last 5 against Nationals: –

Why the Chicago White Sox will win

• The Nationals have lost five of their last six games as favorites against American League opponents.
• The underdogs have won each of the Nationals’ last three games.
• The White Sox have covered the run line in each of their last nine games as underdogs against National League opponents following a loss.
• The Nationals have failed to cover the run line in seven of their last eight games against American League opponents that held a losing record.
• The White Sox have led after 5 innings in seven of their last eight day games against opponents that held a losing record.
• The White Sox have led after 3 innings in four of their last five games as road underdogs against National League opponents.

Total Runs Facts

• Each of the Nationals’ last six day games as favorites have gone UNDER the total runs line.
• Five of the White Sox’s last six games against NL East opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the Nationals’ last six games at Nationals Park.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the White Sox’s last three day games against National League opponents.

Washington Nationals Player Prop Facts

• CJ Abrams has hit a home run in two of the Nationals’ last three games against AL Central opponents.
• Luis Garcia has recorded at least one hit in each of the Nationals’ last seven games as home favorites against AL opponents.

Chicago White Sox Player Prop Facts

• Korey Lee has recorded a Double in three of his last four appearances with the White Sox as road underdogs against NL East opponents.
• Luis Robert has hit a home run in two of his three previous road appearances against the Nationals.
• Mike Tauchman has recorded at least one hit in each of his last nine road appearances against NL opponents that held a losing record.

Chicago White Sox vs Washington Nationals Prediction

I’m not running to the window to get involved in a game with both teams having their bags packed already. The White Sox have also won just two games since September 12. With that said, the White Sox have the edge with Smith on the mound, a rookie who has a 3.98 ERA and 1.24 WHIP. Smith has allowed 25 hits and 13 runs in his last 33.1 innings. Lord has been far more inconsistent, and he has a 5.01 ERA and .280 allowed batting average in 64.2 home innings. Give me the White Sox.