Chicago White Sox vs Minnesota Twins Prediction 9/1/2025 Today’s MLB Picks

In this article, we will formulate a White Sox vs Twins Prediction for this MLB game on Monday, September 1st at the Target Field in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Minnesota Twins Preview

The Minnesota Twins have a 62-74 record this season and are sitting on the 4th place of the AL Central. The Twins have a 35-32 home record and are 63-64 in over/under. They are coming off a 7-2 home victory over the Padres, and are 3-5 in their last 8 games. Over is 9-1 in their last 10 games and are playing the Angels and the Royals next.

The Twins have a .238 batting average this season, .311 OBP and .397 Slugging percentage. Minnesota’s pitching staff has a 4.46 ERA and 1.31 WHIP. Byron Buxton leads the Twins with 109 hits, adding team-highs both in RBI, with 70, and in home runs, with 29. He is also the team’s best hitter with a .271 batting average.

Bailey Ober (R) is the projected starting pitcher for the Twins, and he has a 4-7 record, 5.14 ERA and 1.54 WHIP.

Chicago White Sox Preview

The Chicago White Sox have a 49-88 record this season and are sitting on the last place of the AL Central. The White Sox have a 19-46 road record and are 63-66 in over/under. They are coming off a 3-2 home victory over the Yankees, which ended their five-game losing streak. They are playing the Rays and the Tigers next.

The White Sox have a .233 batting average this season, .302 OBP and .372 Slugging percentage. Chicago’s pitching staff has a 4.24 ERA and 1.37 WHIP. Lenyn Sosa leads the White Sox with 117 hits, and he is the team’s best hitter with a .269 batting average. He also leads the team in RBI with 61, adding a team-high 18 home runs.

Aaron Civale (R) is the projected starting pitcher for the White Sox, and he has a 3-9 record, 5.26 ERA and 1.37 WHIP.

Why the Minnesota Twins will win

• The White Sox have lost 15 of their last 16 road games against AL Central opponents.
• The Twins have won 14 of their last 15 home games against the White Sox.
• The White Sox have failed to cover the run line in each of their last nine Monday road games against AL Central opponents.
• The Twins have covered the run line in seven of their last eight home games against the White Sox.
• The White Sox have trailed after 3 innings in five of their last six games at Target Field.
• The Twins have led after 5 innings in each of their last four games.
• The White Sox have lost the first inning in three of their last four games.

Why the Chicago White Sox will win

• The Twins have lost each of their last seven games following a win.
• The road team has won five of the White Sox’s last six games.
• The Twins have failed to cover the run line in each of their last seven games following a home win.
• The White Sox have covered the run line in each of their last six games following a win.
• The Twins have trailed after 3 innings in each of their last six games against opponents that held a losing record.
• The White Sox have led after 5 innings in each of their last four day games against opponents that held a losing record.
• The White Sox have won the first inning in each of their last three day games against opponents that held a losing record.

Total Runs Facts

• Each of the Twins’ last six games have gone OVER the total runs line.
• Seven of the White Sox’s last eight road games against AL Central opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Twins’ last seven home games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the White Sox’s last four road games against AL Central opponents.

Matchup/League Facts

• The Twins rank 3rd in the league for walks allowed this season (380).
• The Twins rank 26th in the league for opponent batting average this season (.258).
• The White Sox rank 29th in the league for walks allowed this season (507).
• The White Sox rank 28th in the league for hits this season (1060).

White Sox vs Twins Prediction

The White Sox are 3-1 in their last 4 head-to-head meetings against the Twins, but the Twins have won their four meetings before that, and are 3-1 in their last 4 meetings in Minnesota. Over is 6-3-1 in their last 10 meetings.

In this White Sox vs Twins Prediction, the Twins are coming as -170 home favorites. I don’t trust either pitcher in this matchup, and both teams have nothing to play for. Both pitchers have a combined 10.40 ERA, and their home/away splits are not better. Minnesota’s offense has been red-hot lately, with 7+ runs in four of their last five games, and both bullpens have 4.00+ ERA. I expect to see a lot of offense in this game, so take the over 8.5 runs in this one.