Chicago White Sox vs Houston Astros Prediction 6/12/25 MLB Picks

In this article, we will formulate a White Sox vs Astros prediction for this MLB game on Thursday, June 12, at Daikin Park in Houston, Texas. Let’s take a look at the prediction for this MLB matchup.

Chicago White Sox Betting Preview

The Chicago White Sox (23-45, 7-27 Away) are unbeaten in the last two series after splitting with the Tigers and winning over the Royals. Chicago opened the current series against Houston with a 4-2 win, but succumbed to a 10-2 defeat in Game 2. Sean Burke took the loss after allowing seven runs on eight hits with four strikeouts and one walk in 3.2 innings.

This year, the White Sox average 3.51 runs per game (26th in the MLB) on a .222/.296/.343 triple-slash. When it comes to pitching, the White Sox’s staff has a 4.19 ERA (23rd) and 1.38 WHIP (25th). Miguel Vargas leads the White Sox with a .233 batting average, nine home runs, and 30 RBI this season.

The projected starting pitcher for the White Sox is Davis Martin, who is 2-6 in 12 starts this season, with a 3.62 ERA and 1.21 WHIP in 74.2 innings.

Houston Astros Betting Preview

The Houston Astros (37-30, 23-13 Home) are without a loss in the previous six series. They beat the Mariners and Athletics, split with the Rays, and defeated the Pirates and Guardians. Houston fell to the White Sox in Game 1 of the current series, but responded with a comfortable 10-2 victory in Game 2. Christian Walker led the offense with four RBI, while Ryan Gusto got the win after allowing two runs on seven hits with seven strikeouts and one walk across 6.0 innings of work. 

This season, the Astros average 4.07 runs per game (22nd in the MLB) on a .254/.318/.390 triple-slash. When it comes to pitching, the Astros’ staff has a 3.51 ERA (7th) and 1.16 WHIP (2nd). Isaac Paredes leads the Astros with a .254 batting average, 14 home runs, and 41 RBI this season.

Framber Valdez will take the mound for the Astros on Thursday. The 31-year-old left-hander has a 6-4 record in 13 starts this year with a 3.07 ERA and 1.06 WHIP in 85.0 innings.

Why the Astros will cover

• The White Sox have lost nine of their last 10 road games against American League opponents.
• The Astros have won each of their last seven Thursday games against American League opponents that held a losing record.
• The Astros have covered the run line in each of their last four games as favorites after playing the previous day.
• The White Sox have failed to cover the run line in four of their last five games as underdogs against American League opponents following a road loss.
• The White Sox have trailed after 5 innings in three of their last four road games.

Total Runs Facts

• Six of the White Sox’s last seven night games as underdogs have gone OVER the total runs line.
• Four of the Astros’ last five games as favorites against the White Sox have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Astros’ last eight games as favorites against AL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 12 of the White Sox’s last 16 night games against American League opponents.

Matchup/League Facts

• The Astros rank 1st in the league for hits allowed this season (476).
• The Astros rank 4th in the league for strikeouts against this season (511).
• The White Sox rank 30th in the league for slugging percentage this season (.343).
• The White Sox rank 28th in the league for home runs this season (53).

White Sox vs Astros Prediction

The Astros won six of the previous ten H2H encounters, but surprisingly, the White Sox were better in three out of five meetings this season. I am going with the Astros to win and cover the run line mainly because of Framber Valdez, who’s looking for redemption here. Valdez already faced Chicago this year and allowed four runs in a 7-3 loss, but I am sure he will do much better on Thursday. Davis Martin, on the other hand, also pitched against the Astros this season and allowed three runs in an 8-3 loss, but it was a no-decision for him. Martin surrendered multiple runs in six of the previous seven games, and I am backing Houston to score 3+ off him in the opening five or six innings. Back the Astros to win and cover.