Chicago White Sox vs Cleveland Guardians Prediction 9/14/2025 Today’s MLB Picks

The Chicago White Sox and the Cleveland Guardians meet Sunday in MLB action from Progressive Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago White Sox vs. Cleveland Guardians prediction.

Starting Pitching Matchup

The Chicago White Sox will send out Yoendrys Gomez for the start here and Gomez is 3-2 with a 5.05 ERA and 45 strikeouts this season. This will be Gomez’s first career start against the Guardians. Slade Cecconi will get the start for the Guardians here and is 6-6 with a 4.45 ERA and 94 strikeouts this season. This will be Cecconi’s second career start against the White Sox.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to rebound from their 3-1 loss at the hands of the Guardians from Saturday’s matchup to sit at 57-92 this season. After this series, the White Sox will head home for a series against the Baltimore Orioles.

White Sox Looking To Avoid Sweep

Lenyn Sosa has 121 hits including 17 doubles, 20 home runs and 65 RBIs. Andrew Benintendi has 98 hits including 16 doubles, 18 home runs, 58 RBIs and a .247 batting average while Miguel Vargas has 104 hits, 30 doubles, 14 home runs and 52 RBIs. Brooks Baldwin has also added 31 RBIs while Luis Robert Jr. has a team-high 33 stolen bases along with 53 RBIs so far this season. Chase Meidroth has added 101 hits with 13 stolen bases as well as 15 doubles this season.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to add on to their win over the White Sox from Saturday’s matchup to climb to 77-71 on the year. After this series, the Guardians will head on the road for an important division series against the Detroit Tigers.

Guardians Win 9 Of Their Last 11 Games

Steven Kwan has 152 hits as part of a .275 batting average and 10 home runs, 25 doubles and 48 RBIs. Kyle Manzardo has 97 hits with 15 doubles, 2 triples, 25 home runs and 65 RBIs as well this year. Gabriel Arias has 20 doubles but also 139 strikeouts and Manzardo has 119 strikeouts so far this season. Arias has also added 10 home runs and 48 RBIs and Jose Ramirez has chipped in 28 home runs and 76 RBIs with 37 stolen bases as well. Carlos Santana has also added 89 hits with 11 home runs and 52 RBIs as well this season.

The Chicago White Sox @ Cleveland Guardians Betting Trends: September 14, 2025

• Probable Starting Pitcher: Slade Cecconi      Record this season: 6-6      ERA: 4.45
• Home Record: 2-3
• Last 5 against White Sox: 0-1

Why the Cleveland Guardians will win

• The Guardians have won each of their last six home games against the White Sox.
• The White Sox have lost eight of their last nine games at Progressive Field.
• The Guardians have covered the run line in each of their last seven games following a win.
• The White Sox have failed to cover the run line in seven of their last eight games against AL Central opponents following a road loss.
• The White Sox have trailed after 5 innings in each of their last four road games.
• The White Sox have trailed after 3 innings in three of their last four games at Progressive Field.

• Probable Starting Pitcher: Yoendrys Gomez      Record this season: 3-2      ERA: 5.05
• Road Record: 1-1
• Last 5 against Guardians: 0-0

Why the Chicago White Sox will win

• The White Sox have won each of their last five day games against American League opponents.
• The Guardians have lost four of their last five day games against AL Central opponents.
• The White Sox have covered the run line in 12 of their last 13 day games against teams that held a winning record.
• The Guardians have failed to cover the run line in each of their last six day games against AL Central opponents.
• The Guardians have lost the first inning in three of their last four day games against AL Central opponents.
• The Guardians have trailed after 3 innings in three of their last four day games against AL Central opponents.
• The Guardians have trailed after 5 innings in each of their last four day games against American League opponents that held a losing record.

Total Runs Facts

• Seven of the Guardians’ last eight games have gone UNDER the total runs line.
• Each of the White Sox’s last three games have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the White Sox’s last eight Sunday games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of the Guardians’ last 10 games against AL Central opponents.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit a home run in two of the Guardians’ last three day games against AL Central opponents that held a losing record.
• Will Brennan has recorded at least one hit in each of his last six appearances with the Guardians as favorites against AL opponents.
• Will Brennan has recorded at least one Double in each of his last three appearances with the Guardians as favorites against AL opponents.
• Jose Ramirez ranks T3rd in the league in Steals (37) this season.

Chicago White Sox Player Prop Facts

• Andrew Benintendi has hit a home run in two of his last three appearances after playing the previous day.
• Luis Robert has recorded at least one hit in 15 of his last 16 road appearances.

Matchup/League Facts

• The Guardians rank 30th in the league for hits this season (1089).
• The Guardians rank 30th in the league for batting average this season (.225).
• The White Sox rank 29th in the league for walks allowed this season (547).
• The White Sox rank 28th in the league for slugging percentage this season (.376).

Chicago White Sox vs. Cleveland Guardians Prediction

I’m going to take one more stab on Chicago here. The White Sox have not looked good in this series offensively, scoring just one run in the two games played so far, but I think that the White Sox have a decent pitching matchup here. Gomez has had issues in a couple of outings, but I think he can be good enough here against Cecconi, who struggled mightily in his lone start against Chicago this season. I’ll side with the White Sox and the plus money here.