Chicago White Sox vs Arizona Diamondbacks Prediction 4/22/2026 Today’s MLB Picks

The Chicago White Sox and the Arizona Diamondbacks meet Wednesday in MLB action from Chase Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago White Sox vs. Arizona Diamondbacks prediction.

Starting Pitching Matchup

The Chicago White Sox will send out Anthony Kay for the start here and Kay is 1-0 with a 2.60 ERA and 12 strikeouts this season. The Arizona Diamondbacks will trot out Eduardo Rodriguez for the start here and Rodriguez is 1-0 with a 1.96 ERA and 14 strikeous this season.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to add on to their 11-5 win over the Diamondbacks from Tuesday’s opener to sit at 9-14 this season. After this series, the White Sox will head home for a series against the Washington Nationals.

White Sox Win Back-To-Back Games

Munetaka Murakami has 18 hits with 9 home runs and 17 RBIs while Miguel Vargas has 14 hits with 3 doubles, a triple, 4 home runs and 11 RBIs and Colson Montgomery has 17 hits with 5 doubles, 6 home runs and 16 RBIs. Luisangel Acuna has 12 hits and Tristan Peters has 12 hits with a double so far this season. Chase Meidroth also has 20 hits with 5 doubles, a home run and 2 RBIs this year.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to bounce back from their loss at the hands of the White Sox from Tuesday’s game to sit at 13-10 this season. After this series, the Diamondbacks will take on the San Diego Padres in a series at home. 

Diamondbacks Lose 2 In A Row

Corbin Carroll has 21 hits including 6 doubles, 3 triples, 3 home runs and a team-high 16 RBIs while Alek Thomas has logged 7 doubles with 8 RBIs as well this season. Ketel Marte has 19 hits with 2 doubles, 4 home runs and 9 RBIs and Geraldo Perdomo has 17 hits, with 3 doubles, a home run and 5 RBIs as well this season. Gabriel Moreno also has 11 hits with 5 doubles and Jose Fernandez has 19 hits with 2 home runs and 9 RBIs this season. Ildemaro Vargas also has 22 hits with 5 doubles, a triple, 3 home runs and 11 RBIs.

The Chicago White Sox @ Arizona Diamondbacks Betting Trends: April 22, 2026

• Probable Starting Pitcher: Eduardo Rodriguez      Record this season: 1-0      ERA: 1.96
• Home Record: 0-0
• Last 5 against White Sox: 3-0

Why the Arizona Diamondbacks will win

• The White Sox have lost eight of their last nine games following a road win.
• The Diamondbacks have won six of their last seven games against the White Sox following a loss.
• The Diamondbacks have covered the run line in six of their last seven games against AL Central opponents.
• The White Sox have failed to cover the run line in six of their last seven games against the Diamondbacks following a win.
• The Diamondbacks have won the first inning in three of their last four night games against the White Sox.
• The White Sox have trailed after 5 innings in each of their last six Wednesday road games.

• Probable Starting Pitcher: Anthony Kay      Record this season: 1-0      ERA: 2.60
• Road Record: 1-0
• Last 5 against Diamondbacks: –

Why the Chicago White Sox will win

• The White Sox have won four of their last five games as road underdogs.
• The Diamondbacks have lost each of their last four Wednesday night games as favorites against American League opponents.
• The road team has covered the run line in each of the White Sox’s last eight games.
• The Diamondbacks have failed to cover the run line in each of their last eight games following a home loss.
• The White Sox have led after 3 innings in each of their last five games.
• The White Sox have led after 5 innings in each of their last four games.
• The White Sox have won the first inning in each of their last three games against opponents that held a winning record.

Total Runs Facts

• Seven of the White Sox’s last eight games have gone OVER the total runs line.
• Five of the last six games between the White Sox and Diamondbacks have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the last six games between the White Sox and Diamondbacks.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 10 of the White Sox’s last 11 night games against NL West opponents.

Arizona Diamondbacks Player Prop Facts

• Ildemaro Vargas has hit a home run in each of the Diamondbacks’ last two games as favorites against AL Central opponents.
• Eduardo Rodriguez has recorded a win in five of his last six appearances against AL Central opponents that held a losing record.
• Eduardo Rodriguez has recorded five or more strikeouts in each of his last 13 appearances against AL opponents that held a losing record.
• Ildemaro Vargas has recorded at least one hit in each of his last 21 appearances in night games.
• Geraldo Perdomo ranks T10th in the league in Steals (6) this season.

Chicago White Sox Player Prop Facts

• Miguel Vargas has hit a home run in three of the White Sox’s last four games against opponents that held a winning record.
• Andrew Benintendi has recorded at least one hit in each of his seven previous road appearances against the Diamondbacks.
• Munetaka Murakami ranks T2nd in the league in Home Runs (9) this season.

Matchup/League Facts

• The Diamondbacks rank T2nd in the league for doubles this season (48).
• The Diamondbacks rank 2nd in the league for triples this season (6).
• The White Sox rank 29th in the league for batting average this season (.218).
• The White Sox rank T28th in the league for hits this season (165).

Chicago White Sox vs. Arizona Diamondbacks Prediction

I’m on the Diamondbacks in this one. I just think that Rodriguez is the better starter in this matchup, and side-by-side, I trust Arizona’s offense a lot more against left-handed pitching and I think they get to Anthony Kay here, who has had a solid start to his return to Major League Baseball, but in the end I think Rodriguez and the Diamondbacks bats and bullpen do enough to get the win here. Give me Arizona.

Chris Ruffolo's Pick: Arizona -155