Chicago White Sox vs Arizona Diamondbacks Prediction 06/25/2025 Picks

The Arizona Diamondbacks and the Chicago White Sox meet Wednesday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Arizona Diamondbacks vs. Chicago White Sox prediction.

Starting Pitching Matchup

The Arizona Diamondbacks will send out Zac Gallen for the start here and Gallen is 5-8 with a 5.60 ERA and 86 strikeouts this season. This will be Gallen’s second career start against the White Sox. The Chicago White Sox will send out Sean Burke for the start here and Burke is 3-7 with a 4.50 ERA and 61 strikeouts this season. This will be Burke’s first career start against the Diamondbacks.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to build on their 4-1 win over the White Sox from Tuesday to sit at 41-38 on the year. After this series, the Diamondbacks will square off against the Miami Marlins at home.

Diamondbacks Pick Up Win In 5 Of Their Last 6

Corbin Carroll has 73 hits with 20 home runs, 44 RBIs, 9 triples and 13 doubles while Josh Naylor has 87 hits with 18 doubles, 9 home runs and 51 RBIs as well this season. Eugenio Suarez has also added 25 home runs and 67 RBIs while Geraldo Perdomo has 52 RBIs. Naylor has also chipped in 10 stolen bases as well up to this point in the year while Suarez has the unfortunate distinction of leading the Diamondbacks with 82 strikeouts so far this season. Carroll also has 10 stolen bases and Perdomo has a team-high 11 stolen bases as well this season.

Why the Arizona Diamondbacks will win

The Diamondbacks have won each of their last seven games against AL Central opponents.
The White Sox have lost each of their last six games at Rate Field.
The Diamondbacks have covered the run line in each of their last seven day games against American League opponents following a win.
The White Sox have failed to cover the run line in each of their last seven Wednesday games as home underdogs against National League opponents.

Arizona Diamondbacks Player Prop Facts

Zac Gallen has recorded seven or more strikeouts in three of his last four appearances against AL Central opponents.
Zac Gallen has recorded a win in three of his last four road appearances against opponents that held a losing record.
Ketel Marte has hit a home run in eight of the Diamondbacks’ last nine games against AL Central opponents.
Josh Naylor has recorded at least one hit in each of his last 12 appearances.
Eugenio Suarez has recorded a Double in four of his last five appearances against AL Central opponents.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to rebound after taking the loss in Tuesday’s matchup to drop to 25-55 this season. After this series, the White Sox will take on the San Francisco Giants at home.

White Sox Drop Eight Of Last Ten

Lenyn Sosa has 61 hits including 12 doubles and 17 RBIs. Andrew Benintendi has 44 hits including 9 doubles, 8 home runs, 29 RBIs and a .239 batting average while Miguel Vargas has a team-high 67 hits, 20 doubles, 10 home runs and 34 RBIs. Brooks Baldwin has also added 16 RBIs while Luis Robert Jr. has a team-high 22 stolen bases along with 30 RBIs so far this season. Andrew Vaughn has 5 home runs and 19 RBIs as well as 8 doubles this season.

Why the Chicago White Sox will win

The White Sox have won seven of their last 10 games as home underdogs following a home loss.
The Diamondbacks have lost each of their last four day games against teams that held a losing record.
The Diamondbacks have failed to cover the run line each of their last four day games against teams that held a losing record.
The White Sox have covered the run line in six of their last seven day games following a home loss.

Chicago White Sox Player Prop Facts

Andrew Benintendi has hit a home run in two of the White Sox’s last three day games against NL opponents that held a winning record.
Korey Lee has recorded at least one hit in each of his last six appearances against NL opponents that held a winning record.
Luis Robert ranks T4th in the league in Steals (22) this season.

Total Runs Facts

Ten of the Diamondbacks’ last 12 road games against American League opponents have gone OVER the total runs line.
Five of the White Sox’s last six games after playing the previous day have gone UNDER the total runs line.

Arizona Diamondbacks vs. Chicago White Sox Prediction

I’m on Arizona here. I just think that while Zac Gallen has really struggled in his recent outings, the White Sox haven’t been a team that seem like they can give Gallen problems. This could be a great spot for Gallen to hit the reset button. Sean Burke hasn’t been a top-tier starter by any stretch, and I think this could be a great spot for the Diamondbacks to keep the momentum going against a clearly inferior opponent. Give me the Diamondbacks here.