Chicago Cubs vs St. Louis Cardinals Prediction 8/9/2025 Today’s MLB Picks

The Chicago Cubs and St. Louis Cardinals meet Saturday in MLB action at Busch Stadium. Here’s a Chicago Cubs vs St. Louis Cardinals Prediction. This article will include a Chicago Cubs vs St. Louis Cardinals Pick.

Chicago Cubs Betting Preview

The Chicago Cubs are 66-49 on the year and play the Blue Jays, Pirates, and Brewers next. The Chicago Cubs are batting .253 on the season, have a .322 OBP, and a .437 slugging percentage. The Chicago Cubs pitching staff has a 3.91 ERA and a 1.22 WHIP. Nico Hoerner leads the Chicago Cubs with 123 hits and 47 RBI, while Pete Crow-Armstrong and Kyle Tucker have combined for 227 hits and 139 RBI. 

Colin Rea gets the ball for the Chicago Cubs, and he is 8-5 with a 4.23 ERA and 79 strikeouts this season. Rea is 2-3 with a 3.89 ERA and 31 strikeouts in his career against the St. Louis Cardinals.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 59-58 on the year and play the Rockies, Yankees, and Marlins next. The St. Louis Cardinals are batting .251 on the season, have a .320 OBP, and a .389 slugging percentage. The St. Louis Cardinals pitching staff has a 4.18 ERA and a 1.29 WHIP. Brendan Donovan leads the St. Louis Cardinals with 115 hits and 43 RBI while Masyn Winn and Willson Contreras have combined for 212 hits and 107 RBI.

Andre Pallante gets the ball for the St. Louis Cardinals, and he is 6-8 with a 4.57 ERA and 80 strikeouts this season. Pallante is 0-3 with a 2.67 ERA and 15 strikeouts in his career against the Chicago Cubs.

Why the St. Louis Cardinals will win

• The Cubs have lost each of their last five night games against NL Central opponents.
• The Cardinals have won each of their last six games as home favorites against NL Central opponents.
• The Cubs have failed to cover the run line in each of their last five night games against NL Central opponents.
• The Cardinals have covered the run line in three of their last four games against teams that held a winning record.
• The Cardinals have led after 5 innings in four of their last five night games at Busch Stadium against NL Central opponents.
• The Cardinals have led after 3 innings in each of their last three games as home favorites against NL Central opponents.

Why the Chicago Cubs will win

• The Cardinals have lost each of their last six games as favorites against National League opponents following a win.
• The underdogs have won six of the Cardinals’ last seven games at Busch Stadium.
• The Cardinals have failed to cover the run line in each of their last eight games as favorites against National League opponents following a home win.
• The Cubs have covered the run line in 13 of their last 14 games as road underdogs against National League opponents following a road loss.
• The Cardinals have trailed after 5 innings in four of their last five games as home favorites against National League opponents.
• The Cardinals have trailed after 3 innings in three of their last four home games against NL Central opponents that held a winning record.

St. Louis Cardinals Player Prop Facts

• Lars Nootbaar has hit a home run in each of his last two appearances at Busch Stadium against NL Central opponents that held a winning record.
• Masyn Winn has recorded at least one hit in each of his last 10 Saturday appearances against NL teams that held a winning record.

Chicago Cubs Player Prop Facts

• Carson Kelly has hit a home run in two of his last three appearances against former teams.
• Nico Hoerner has recorded at least one hit in each of the Cubs’ last 11 road games against the Cardinals.
• Seiya Suzuki has recorded a Double in three of the Cubs’ last four games as road underdogs.
• Seiya Suzuki ranks T7th in the league in Home Runs (27) this season.

Chicago Cubs vs St. Louis Cardinals Prediction

The Cubs are due for an offensive breakthrough after a slow week. Rea has been hirable on the road, where he has a 4.12 ERA and .290 allowed batting average in 43.2 innings. Pallante has struggled all season and has allowed 32 hits and 19 earned runs in his last 34.2 innings. At home, Pallante has a 4.39 ERA and .245 allowed batting average in 55.1 innings. The Cards have scored five or more runs in four of their last six games. Expect some fireworks. Give me the over.