Chicago Cubs vs St. Louis Cardinals Prediction 8/11/2025 Today’s MLB Picks

In this article, we will formulate a Cubs vs Cardinals prediction for this MLB game on Sunday, August 10, at Busch Stadium in St. Louis, Missouri. Let’s take a look at the prediction for this MLB matchup.

Chicago Cubs Betting Preview

The Chicago Cubs (67-49, 31-27 Away) defeated the Baltimore Orioles and lost to the Cincinnati Reds in two home series before taking on the Cardinals in St. Louis. The Cubs failed to score in a 5-0 loss in Game 1, but responded in style with a 9-1 victory in Game 2. Michael Busch led the offense with three RBI, while Colin Rea got the win after allowing one run on three hits with six strikeouts and two walks across 6.0 innings of work.

This season, the Cubs average 5.16 runs per game (1st in the MLB) on a .253/.323/.439 triple-slash. When it comes to pitching, the Cubs’ staff has a 3.89 ERA (16th) and 1.21 WHIP (6th). Seiya Suzuki leads the Cubs with a .251 batting average, 27 home runs, and 84 RBI this season.

Shota Imanaga will take the mound for the Cubs on Sunday. The 31-year-old left-hander has an 8-4 record in 16 starts this year with a 3.12 ERA and 1.00 WHIP in 89.1 innings.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals (59-59, 33-25 Home) couldn’t get a series win in the second half of the season, but then they met the Los Angeles Dodgers and recorded a W. After that, the Cards opened the series against the Cubs with a 5-0 win, but were well-beaten in Game 2 on Saturday, losing 9-1. Alec Burleson drove in the lone run for the offense, while Andre Pallante took the loss after allowing six runs on seven hits with no strikeouts and one walk in 1.2 innings.

This year, the Cardinals average 4.39 runs per game (14th in the MLB) on a .249/.319/.388 triple-slash. When it comes to pitching, the Cardinals’ staff has a 4.22 ERA (21st) and 1.29 WHIP (18th). Willson Contreras leads the Cardinals with a .260 batting average, 16 home runs, and 65 RBI this season.

The projected starting pitcher for the Cardinals is Sonny Gray, who is 10-5 in 23 starts this season, with a 4.21 ERA and 1.17 WHIP in 128.1 innings.

Total Runs Facts

• Five of the Cubs’ last six road games have gone OVER the total runs line.
• Four of the Cardinals’ last five games as underdogs against NL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Cardinals’ last five games as underdogs against NL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in four of the Cubs’ last five games.

Matchup/League Facts

• The Cardinals rank 3rd in the league for walks allowed this season (308).
• The Cardinals rank 5th in the league for doubles this season (204).
• The Cubs rank 2nd in the league for walks allowed this season (301).
• The Cubs rank 3rd in the league for slugging percentage this season (.439).

Cubs vs Cardinals Prediction

The Cubs won six of the previous ten H2H encounters, while this season, Chicago leads the series 5-4. Four of the last five H2Hs went Over, and I am backing another Over in this one, even though Shota Imanaga and Sonny Gray are starting. Imanaga allowed 11 runs in his previous three starts, while he posted a 4.32 ERA in July, which is below his standards. Gray, on the other hand, was disastrous in July, posting a bloated 7.81 ERA, so I expect both offenses to score 3+ runs in the opening six runs. Back the Over.