Chicago Cubs vs Milwaukee Brewers Prediction 5/4/25 MLB Picks

In this article, we will formulate a Cubs vs Brewers prediction for this MLB game on Sunday, May 4, at American Family Field in Milwaukee, Wisconsin. Let’s take a look at the prediction for this MLB matchup.

Chicago Cubs Betting Preview

The Chicago Cubs (21-13, 12-6 Away) bounced back from a series loss to the Phillies with wins over the Pirates and Brewers. It’s clear the Cubs will win the series in Milwaukee after defeating the hosts 10-0 and 6-2 in the opening two games. Pete Crow-Armstrong led the offense in the recent victory with a three-run homer, while Jameson Taillon got the win after allowing two runs on three hits with five strikeouts and one walk over 6.0 innings of work.

This season, the Cubs average 6.12 runs per game (1st in the MLB) on a .266/.343/.461 slash line. Regarding pitching, the Cubs’ staff has a 3.86 ERA (15th) and 1.32 WHIP (21st). Kyle Tucker leads the Cubs with a .284 batting average, nine home runs, and 30 RBI this season.

The projected starting pitcher for the Cubs is Shota Imanaga, who is 3-1 in seven starts this season, with a 2.77 ERA and 1.13 WHIP in 39.0 innings.

Milwaukee Brewers Betting Preview

The Milwaukee Brewers (16-18, 9-6 Home) responded to the previous poor run of four losses with three straight wins, but returned to losing ways and now are on a three-game losing skid. During this stretch, the Brewers failed to score a run in two games and scored just two in total. Those two runs came in the latest 6-2 defeat to the Cubs. Before this series, Milwaukee lost to the Giants and the Cardinals and beat the White Sox. Jose Quintana took the loss on Saturday after allowing six runs on seven hits with six strikeouts and one walk in 5.0 innings.

This year, the Brewers average 4.82 runs per game (9th in the MLB) on a .242/.321/.362 triple-slash. When it comes to pitching, the Brewers’ staff has a 4.41 ERA (25th) and 1.36 WHIP (23rd). Jackson Chourio leads the Brewers with a .255 batting average, six home runs, and 24 RBI this season.

Freddy Peralta will take the mound for the Brewers on Sunday. The 28-year-old right-hander has a 3-2 record in seven starts this year with a 2.52 ERA and 1.07 WHIP in 39.1 innings.

Total Runs Facts

• Six of the last eight games between the Cubs and Brewers at American Family Field have gone OVER the total runs line.
• Three of the Cubs’ last four day games as favorites have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Brewers’ last six games as home underdogs.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cubs’ last four road games.

Matchup/League Facts

• The Brewers rank 24th in the league for slugging percentage this season (.359).
• The Brewers rank 24th in the league for ERA this season (4.45).
• The Cubs rank 1st in the league for triples this season (9).
• The Cubs rank 1st in the league for RBIs this season (204).

Cubs vs Brewers Prediction

The Brewers won six of the previous ten H2H encounters, but the Cubs were better in four of the last six. Freddy Peralta owns the Cubs in his career; he allowed a .171 BA in 117 at-bats against them. I am leaning toward the Brewers because of Peralta’s record vs. the Cubs. In three starts (17.2 innings) against Chicago last year, Peralta posted a 2.55 ERA. Shota Imanaga wasn’t that successful in his lone start against the Brewers, as he registered a 14.54 ERA in 4.1 innings. Still, the Brewers are struggling offensively right now, and Imanaga will have better numbers on Sunday. I am going with Under.