Chicago Cubs vs Milwaukee Brewers Prediction 10/6/2025 Today’s MLB Picks

In this article, we will formulate a Cubs vs Brewers Prediction for this MLB game on Monday, October 6th at the American Family Field in Game 2 of this NLDS series, with the Brewers having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Milwaukee Brewers Preview

The Milwaukee Brewers finished the regular season with a 97-65 record and were placed first in the NL Central. The Brewers have a 53-29 home record and are 78-80 in over/under. They are coming off a 9-3 home victory over the Cubs in Game 1, and have back-to-back wins. Under is 6-3 in their last 9 games.  

The Brewers have a .258 batting average this season, .332 OBP and .403 slugging percentage. Milwaukee’s pitching staff has a 3.58 ERA and 1.23 WHIP. Jackson Chourio leads the Brewers with 3 hits in the playoffs, adding a team-high 3 RBI. Blake Perkins is the team’s best hitter, with a .500 batting average.

Reliever Aaron Ashby (L) is the projected starting pitcher for the Brewers, and he has a 5-2 record, 2.16 ERA and 1.17 WHIP.

Chicago Cubs Preview

The Chicago Cubs finished the regular season with a 92-70 record and were placed second in the NL Central. The Cubs have a 42-40 road record and are 75-78 in over/under. They are coming off a 3-9 road defeat by the Brewers, and have lost two of their last three games. Under is 4-1 in their last 5 games.

The Cubs have a .249 batting average this season, .320 OBP and .430 Slugging percentage. Chicago’s pitching staff has a 3.79 ERA and 1.18 WHIP. Nico Hoerner leads the team with 5 hits, adding a team-high 2 RBI. Michael Busch is the team’s best hitter, adding a team-high two home runs.

Shota Imanaga (L) is the projected starting pitcher for the Cubs, and he has a 0-0 record, 4.50 ERA and 1.25 WHIP in the postseason.

The Chicago Cubs @ Milwaukee Brewers Betting Trends: October 6, 2025

• Probable Starting Pitcher: Aaron Ashby      Record this season (inc. playoffs): 5-2      ERA: 2.12
• Home Record: 1-1
• Last 5 against Cubs: 0-0

Why the Milwaukee Brewers will win

• The favorites have won each of the Cubs’ last nine games.
• The Cubs have lost each of their last five road games.
• The favorites have covered the run line in each of the Cubs’ last nine games.
• The Cubs have failed to cover the run line in each of their last five road playoff games.
• The Brewers have led after 3 innings in each of their last eight Monday games against National League opponents that held a winning record.
• The Cubs have lost the first inning in each of their last three games as underdogs.
• The Cubs have trailed after 5 innings in each of their last six games as underdogs.

• Probable Starting Pitcher: Shota Imanaga      Record this season (inc. playoffs): 9-8      ERA: 3.75
• Road Record: 5-5
• Last 5 against Brewers: 1-3

Why the Chicago Cubs will win

• The Brewers have lost each of their last six night games against teams that held a winning record.
• The Cubs have won four of their last five playoff games as underdogs following a loss.
• The Brewers have failed to cover the run line in each of their last seven night games against National League opponents.
• The Cubs have covered the run line in 16 of their last 18 games as underdogs against National League opponents following a road loss.
• The Brewers have trailed after 3 innings in five of their last six playoff games against NL Central opponents.
• The Cubs have won the first inning in three of their last four night games at American Family Field.
• The Cubs have led after 5 innings in five of their last six road night playoff games.

Total Runs Facts

• Each of the last four games between the Cubs and Brewers at American Family Field have gone OVER the total runs line.
• Each of the Cubs’ last four playoff games against NL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Brewers’ last four night games at American Family Field.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cubs’ last three games as underdogs.

Milwaukee Brewers Player Prop Facts

• Christian Yelich has hit a home run in three of his last five home appearances after not playing the previous day.
• Brice Turang has recorded at least one hit in each of the Brewers’ last nine games against NL Central opponents that held a winning record.
• Jackson Chourio has recorded a Double in four of his last five appearances against the Cubs after not playing the previous day.

Chicago Cubs Player Prop Facts

• Nico Hoerner has hit a home run in three of the Cubs’ last four games as road underdogs against the Brewers.
• Ian Happ has recorded a Double in four of the Cubs’ last five night games.
• Ian Happ has recorded at least one hit in each of the Cubs’ last seven road games against the Brewers.
• Nico Hoerner ranks 6th in the league in Hits (178) this season.

Matchup/League Facts

• The Brewers rank 2nd in the league for on-base percentage this season (.332).
• The Brewers rank 2nd in the league for steals this season (164).
• The Cubs rank 1st in the league for walks allowed this season (405).
• The Cubs rank T3rd in the league for RBIs this season (771).

Cubs vs Brewers Prediction

The Cubs are 3-2 in their last 5 meetings against the Brewers, but the Brewers are 3-1 in their last 4 meetings in Milwaukee. Over is 4-0 in their last 4 meetings in Milwaukee.

In this Cubs vs Brewers Prediction, the Brewers are coming as -125 home favorites. The Brewers blew out the Cubs in Game 1 with a 9-3 score, but they are going for a bullpen game today. They have a slightly better bullen ERA than the Cubs, who are putting Imanaga on the mound, who has been atrocious lately, with a 6.51 ERA across his last five starts. He has at least 3 earned runs in six of his last seven starts, and I don’t trust him on the road in this spot. The Brewers have a better offense, and are the best team against lefties in baseball, while the Cubs are weaker against southpaws. Take the Milwaukee Brewers to get the job done at home in this one.