Jul 29, 2025; Milwaukee, Wisconsin, USA; Milwaukee Brewers shortstop Andruw Monasterio (14) dumps Gatorade over Milwaukee Brewers first base Andrew Vaughn (28) head after the game in which Milwaukee  Andrew Vaughn (28) hit a grand slam against the Chicago Cubs at American Family Field. Mandatory Credit: Michael McLoone-Imagn Images

Chicago Cubs vs Milwaukee Brewers Prediction 07/30/2025 Picks

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Chicago (62-45) vs Milwaukee (64-43)

July 30, 2025 at 02:10 PM EDT

The Line: Betting Odds: Milwaukee +1.5 — Over/Under: +7.5

(Get latest betting odds)

The Chicago Cubs and Milwaukee Brewers meet Wednesday in MLB action at American Family Field. Here’s a Chicago Cubs vs Milwaukee Brewers Prediction. This article will include a Chicago Cubs vs Milwaukee Brewers Pick.

Chicago Cubs Betting Preview

The Chicago Cubs are 62-45 on the year and play the Orioles, Reds, and Cardinals next. The Chicago Cubs are batting .255 on the season, have a .325 OBP, and a .442 slugging percentage. The Chicago Cubs pitching staff has a 3.97 ERA and a 1.24 WHIP. Nico Hoerner leads the Chicago Cubs with 115 hits and 43 RBI, while Pete Crow-Armstrong and Kyle Tucker have combined for 216 hits and 136 RBI. 

Shota Imanaga gets the ball for the Chicago Cubs, and he is 7-4 with a 3.12 ERA and 55 strikeouts this season. Imanaga is 0-2 with a 8.10 ERA and 5 strikeouts in his career against the Milwaukee Brewers.

Milwaukee Brewers Betting Preview

The Milwaukee Brewers are 64-43 on the year and play the Nationals, Braves, and Mets next. The Milwaukee Brewers are batting .251 on the season, have a .325 OBP, and a .387 slugging percentage. The Milwaukee Brewers pitching staff has a 3.57 ERA and a 1.24 WHIP. Jackson Chourio leads the Milwaukee Brewers with 123 hits and 67 RBI while Brice Turang and Sal Frelick have combined for 211 hits and 84 RBI.

Freddy Peralta gets the ball for the Milwaukee Brewers, and he is 12-4 with a 2.81 ERA and 131 strikeouts this season. Peralta is 8-2 with a 3.07 ERA and 122 strikeouts in his career against the Chicago Cubs.

Why the Milwaukee Brewers will win

  • The Brewers have won each of their last eight games following a home win.
  • The Cubs have lost six of their last seven games at American Family Field against teams that held a winning record.
  • The Brewers have covered the run line each of their last nine games against National League opponents that held a winning record.
  • The Cubs have failed to cover the run line in 12 of their last 13 Wednesday games against National League opponents.
  • The Cubs have trailed after 3 innings in each of their last three games as road underdogs against NL Central opponents.
  • The Brewers have led after 5 innings in each of their last four home games against NL Central opponents.

Why the Chicago Cubs will win

  • The Cubs have won each of their last eight day games against National League opponents following a road loss.
  • The Cubs have covered the run line in 13 of their last 14 games as underdogs against National League opponents following a road loss.
  • The Brewers have failed to cover the run line in nine of their last 10 games as home favorites against NL Central opponents following a home win.

Milwaukee Brewers Player Prop Facts

  • Andrew Vaughn has hit a home run in three of the Brewers’ last four games against NL opponents.
  • Andrew Vaughn has recorded at least one hit in each of his 13 previous appearances at American Family Field.
  • Freddy Peralta has recorded seven or more strikeouts in each of his last four home appearances.
  • Freddy Peralta has recorded a win in seven of his last eight appearances against NL opponents.
  • Brice Turang has recorded a Double in three of his last four appearances in day games against NL teams that held a winning record.

Chicago Cubs Player Prop Facts

  • Carson Kelly has hit a home run in each of the Cubs’ last two day games against NL Central opponents that held a winning record.
  • Nico Hoerner has recorded at least one hit in each of the Cubs’ last nine road games against NL Central opponents.
  • Shota Imanaga has recorded a win in each of his last three appearances with the Cubs as road underdogs.
  • Seiya Suzuki has recorded a Double in each of the Cubs’ last three games as road underdogs.

Chicago Cubs vs Milwaukee Brewers Prediction

The Cubs have been in a funk over the last week or so and as talented as Imanaga is, he has a .316 allowed batting average and .333 on base percentage in 38 at bats against current Brewers. The Brewers continue to win and Peralta is dealing, which includes 20 hits and eight runs allowed in his last 28.2 innings. The Brewers have won seven of Peralta’s last eight starts. Peralta has a 1.55 ERA and .202 allowed batting average in 63.2 home innings. In 145 at bats against current Cubs, Peralta is allowing a .166 batting average with 52 strikeouts. Give me the Brewers.

Randy Chambers's Pick: Milwaukee Brewers

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