Aug 22, 2025; Anaheim, California, USA; Chicago Cubs center fielder Pete Crow-Armstrong (4) crosses home plate after hitting a home run in the ninth inning as Los Angeles Angels relief pitcher Kenley Jansen (74) and catcher Logan O'Hoppe (14) and home plate umpire Adrian Johnson watch at Angel Stadium. Mandatory Credit: Kirby Lee-Imagn Images

Chicago Cubs vs Los Angeles Angels Prediction 8/23/2025 Today’s MLB Picks

Pick details

Chicago (74-55) vs Los Angeles (61-67)

August 23, 2025 at 09:38 PM EDT

The Line: Betting Odds: Los Angeles 0.0001 — Over/Under: 0.0001

(Get latest betting odds)

The Chicago Cubs and Los Angeles Angels meet Saturday in MLB action at Angel Stadium. Here’s a Chicago Cubs vs Los Angeles Angels Prediction. This article will include a Chicago Cubs vs Los Angeles Angels Pick.

Chicago Cubs Betting Preview

The Chicago Cubs are 74-55 on the year and play the Giants, Rockies, and Braves next. The Chicago Cubs are batting .248 on the season, have a .319 OBP, and a .426 slugging percentage. The Chicago Cubs pitching staff has a 3.79 ERA and a 1.20 WHIP. Nico Hoerner leads the Chicago Cubs with 135 hits and 49 RBI, while Pete Crow-Armstrong and Dansby Swanson have combined for 242 hits and 138 RBI.

Cade Horton gets the ball for the Chicago Cubs, and he is 7-4 with a 3.08 ERA and 70 strikeouts this season. This will be Horton’s first career game against the Los Angeles Angels.

Los Angeles Angels Betting Preview

The Los Angeles Angels are 61-67 on the year and play the Rangers, Astros, and Royals next. The Los Angeles Angels are batting .232 on the season, have a .305 OBP, and a .407 slugging percentage. The Los Angeles Angels pitching staff has a 4.66 ERA and a 1.43 WHIP. Nolan Schanuel leads the Los Angeles Angels with 123 hits and 49 RBI while Zach Neto and Taylor Ward have combined for 226 hits and 147 RBI.

Victor Mederos gets the ball for the Los Angeles Angels, and he is 0-1 with a 5.54 ERA and 10 strikeouts this season. This will be Mederos’ first career game against the Chicago Cubs.

Why the Los Angeles Angels will win

  • The Cubs have lost each of their last four road games following a win.
  • The Angels have won five of their last six games against National League opponents following a home loss.
  • The Cubs have failed to cover the run line in each of their last six games against American League opponents following a win.
  • The Angels have covered the run line in 21 of their last 28 night games following a loss.

Why the Chicago Cubs will win

  • The Cubs have won eight of their last nine road games against AL West opponents that held a losing record.
  • The Angels have lost five of their last six games at Angel Stadium of Anaheim against NL Central opponents that held a winning record.
  • The Angels have failed to cover the run line in seven of their last eight games against NL Central opponents.
  • The Cubs have covered the run line in each of their last seven Saturday night road games.
  • The Angels have trailed after 5 innings in five of their last six home games against NL Central opponents that held a winning record.
  • The Angels have trailed after 3 innings in six of their last seven night games.

Los Angeles Angels Player Prop Facts

  • Yoan Moncada has hit at least one home run in each of the Angels’ last two home games against NL Central opponents.
  • Nolan Schanuel has recorded at least one hit in each of the Angels’ last 10 Saturday night games against opponents that held a winning record.

Chicago Cubs Player Prop Facts

  • Nico Hoerner has recorded at least one hit in each of the Cubs’ last eight road games against AL West opponents.
  • Kyle Tucker has hit a home run in five of his last six appearances in night games against AL West teams that held a losing record.

Chicago Cubs vs Los Angeles Angels Prediction

The Cubs are not only the better team, but Horton has been ridiculous lately, allowing 15 hits and two runs in his last 31 innings. That’s just an elite stretch you shouldn’t be stepping in front of, honestly. Also, Mederos has pitched 21.1 MLB innings and has a 7.59 ERA and 2.11 WHIP. Up to this point, it’s fair to say Mederos is not a major league pitcher. This is a complete pitching mismatch. Give me the Cubs.

Randy Chambers's Pick: Chicago Cubs

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