Chicago Cubs vs Los Angeles Angels Prediction 8/22/2025 Today’s MLB Picks

In this article, we will formulate a Cubs vs Angels Prediction for this MLB game on Friday, August 22nd at the Angel Stadium in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Los Angeles Angels Preview

The Los Angeles Angels have a 61-66 record this season and are sitting on the 4th place of the AL West. The Angels have a 34-32 home record and 71-53 in over/under They are coming off a 2-1 home victory over the Reds, which ended their previous two-game losing streak. Over is 9-3 in their last 12 games and are playing the Astros and the Rangers next.

The Angels have a .233 batting average this season, .306 OBP and .407 Slugging percentage. LA’s pitching staff has a 4.67 ERA and 1.43 WHIP. Nolan Schanuel leads the Angels with 123 hits, and he is the team’s best hitter with a .269 batting average. Taylor Ward leads the team with 92 RBI, adding a team-high 29 home runs.

Tyler Anderson (L) is the projected starting pitcher for the Angels, and he has a 2-8 record, 4.77 ERA and 1.42 WHIP.

Chicago Cubs Preview

The Chicago Cubs have a 73-55 record this season and are sitting on the second place of the NL Central. The Cubs have a 32-30 road record and are 58-59 in over/under. They are coming off a 1-4 home victory over the Brewers, which ended their three-game winning streak. Under is 9-2-1 in their last 12 games, and are playing the Rockies and the Giants next.

The Cubs have a .249 batting average this season, .319 OBP and .427 Slugging percentage. Chicago’s pitching staff has a 3.81 ERA and 1.21 WHIP. Nico Hoerner leads the Cubs with 134 hits, and he is the team’s best hitter with a .289 batting average. Seiya Suzuki leads the team in RBI, with 86, adding a team-high 27 home runs.

The Cubs have not yet announced a starting pitcher for this game.

Why the Los Angeles Angels will win

• The Cubs have lost four of their last five games as road favorites.
• The underdogs have won four of the Cubs’ last five games.
• The Angels have covered the run line each of their last eight Friday games against teams that held a winning record.
• The Cubs have failed to cover the run line in each of their last six Friday road games against American League opponents.
• The Cubs have trailed after 5 innings in each of their last seven Friday night games.
• The Cubs have trailed after 3 innings in 11 of their last 14 road night games.

Why the Chicago Cubs will win

• The Cubs have won each of their last eight games as road favorites against AL West opponents.
• The Angels have lost each of their last four home games against NL Central opponents following a win.
• The Angels have failed to cover the run line in each of their last eight home games against NL Central opponents.
• The Cubs have covered the run line in each of their last six games as road favorites against AL West opponents.
• The Cubs have won the first inning in four of their last five night games against AL West opponents that held a losing record.
• The Cubs have led after 5 innings in seven of their last eight games as favorites against AL West opponents.
• The Angels have trailed after 3 innings in seven of their last eight home games against NL Central opponents.

Total Runs Facts

• Each of the Cubs’ last eight games as favorites against AL West opponents have gone OVER the total runs line.
• Each of the last five games between the Cubs and Angels have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Angels’ last nine games as underdogs.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Cubs’ last eight games as favorites.

Matchup/League Facts

• The Angels rank 30th in the league for strikeouts against this season (1245).
• The Angels rank 30th in the league for walks allowed this season (485).
• The Cubs rank 1st in the league for walks allowed this season (337).
• The Cubs rank T3rd in the league for RBIs this season (613).

Cubs vs Angels Prediction

The Angels are 4-2 in their last 6 meetings against the Cubs, having won their last three meetings in Los Angeles. Under is 7-2-1 in their last 10 meetings.

In this Cubs vs Angels Prediction, the Cubs are coming as -150 road favorites. The Cubs are big road favorites, but given the uncertainty behind their starting pitcher, I’m not rushing to back them up. Andreson has been very good at home for the Angels, with a 3.82 home ERA, and the Angels have more home wins than the Cubs have on the road. On top of that, the Cubs are much weaker against left-handed pitching, so I like the chances of the Angels as home dogs in this one,