Cardinals vs Reds Prediction 8/29/2025 Today’s MLB Picks

In this article we will formulate a Cardinals vs Reds prediction for this MLB game on Friday, August 29th at Great American Ball Park in Cincinnati, Ohio. Let’s take a look at the prediction for this MLB matchup. 

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 66-69 this year after they split four games with Pittsburgh by scores of 7-6, 3-8, 1-2, and 4-1. In their game four win, St. Louis trailed 1-0 in the first inning, but they scored the last four runs to get the victory. The Cardinals recorded seven hits in the game and they were led by Walker, who went 1-3 with one home run and two RBIs in the win. St. Louis started Mikolas, who allowed four hits and one earned run over 5.0 innings, while Leahy picked up the win and Romero got the save. 

Prior to that series, the Cardinals lost two out of three against the Rays, but did win two out of three against the Marlins before that. St. Louis has lost four of their last six games and they are fourth in the NL Central standings. The St. Louis pitching staff has a 4.28 ERA with a 1.30 WHIP and a .257 opponent batting average, while their offense has scored 588 runs with a .248 batting average and a .316 on base percentage this season. Wilson Contreras has led St. Louis with 19 home runs, 73 RBIs, and four stolen bases, while Alec Burleson has added 16 home runs and 60 RBIs this year. The projected starting pitcher for St. Louis is Matthew Liberatore, who is 6-11 with a 4.27 ERA and a 1.29 WHIP over 126.1 innings pitched this year. 

Cincinnati Reds Betting Preview

The Cincinnati Reds are 68-66 this season after they lost all three games against the Dodgers by scores of 0-7, 3-6, and 1-5. In their game three loss, Cincinnati took a 1-0 lead in the third inning, but failed to score in the last six innings for the loss. The Reds recorded six hits in the game and they were led by Marte, who went 1-4 with one home run and one RBI in the loss. Cincinnati started Lodolo, who allowed five hits and four earned runs over 4.2 innings for the loss, while Suter allowed one earned run in relief. 

Prior to that series, the Reds lost two out of three against the Diamondbacks, but did win two out of three against the Angels before that. Cincinnati has lost six of their last seven games and they are currently third in the NL Central standings. The Cincinnati pitching staff has a 3.84 ERA with a 1.24 WHIP and a .235 opponent batting average, while their offense has scored 597 runs with a .246 batting average and a .316 on base percentage this season. Elly De La Cruz has led Cincinnati with 19 home runs and 77 RBIs, while Spencer Steer has added 16 home runs and 62 RBIs this year. The projected starting pitcher for Cincinnati is Zack Littell, who is 9-8 with a 3.62 ERA and a 1.14 WHIP over 154.0 innings pitched this season. 

Why the Reds will beat the Cardinals 

The Cardinals have lost eight of their last nine road games following a win.
The Reds have won four of their last five games at Great American Ball Park following a loss.
The Cardinals have failed to cover the run line in each of their last six games following a home win.
The Reds have covered the run line in six of their last seven games against teams that held a losing record.

Total Runs Facts

Eight of the Reds’ last nine games as favorites against the Cardinals have gone UNDER the total runs line.
Four of the Cardinals’ last five road games after playing the previous day have gone OVER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Cardinals’ last 10 night games.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in four of the Reds’ last five games as favorites against NL Central opponents.

Cincinnati Reds Player Prop Facts

Jose Trevino has recorded a Double in three of his last four appearances against the Cardinals after not playing the previous day.
Jose Trevino has recorded at least one hit in each of his six previous appearances against the Cardinals after not playing the previous day.
Jose Trevino has hit a home run in two of his three previous appearances against the Cardinals at Great American Ball Park.
St. Louis Cardinals Player Prop Facts
Nolan Arenado has recorded at least one hit in each of his last seven road appearances against opponents that held a winning record.
Willson Contreras has hit a home run in three of the Cardinals’ last four road games.

Cardinals vs Reds Prediction 

Cincinnati comes into this matchup really struggling over the last week, but they need to find a win to get back into the wild card race. The Reds are 36-29 at home this season, while the Cardinals are 29-37 on the road. St. Louis has been wildly inconsistent this year and they are starting Liberatore, who has allowed 4, 3, and 3 earned runs in his last three outings. Cincinnati is going with Littell, who has allowed 3, 1, 4, and 1 earned run in four starts with the team. I don’t trust Liberatore at all, so give me the Reds to win at home.