Boston Red Sox vs Houston Astros Prediction 08/01/2025 Picks

The Houston Astros and the Boston Red Sox meet Friday in MLB action from Fenway Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Houston Astros vs. Boston Red Sox prediction.

Starting Pitching Matchup

The Houston Astros will send out Hunter Brown for the start here and Brown is 9-5 with a 2.54 ERA and 149 strikeouts this season. This will be Brown’s second career start against the Red Sox. Boston did not have a starting pitcher announced at the time that this article was posted.

Houston Astros Recap

The Houston Astros come into this game looking to build on their 9-1 win over the Washington Nationals to improve to 62-47 on the year. After this series, the Astros will head on the road for a series against the Miami Marlins.

Astros Pick Up Series Win Vs. Nationals

Jose Altuve has 114 hits including 17 doubles, 18 home runs and 57 RBIs. Jeremy Pena also has 102 hits with 18 doubles, 11 homers and 40 RBIs with 15 stolen bases as well. Jake Meyers has 15 doubles as well and Christian Walker has 13 home runs and 55 RBIs but has also accrued a team-high 116 strikeouts so far this season. Altuve also has 6 stolen bases while Jake Meyers has 14 stolen bases this season. Isaac Paredes also has a team-high 19 home runs with 50 RBIs of his own and Cam Smith has contributed 7 homers and 45 RBIs.

Why the Houston Astros will win

• The Astros have won each of their last eight games at Fenway Park against AL East opponents that held a winning record.
• The Red Sox have lost nine of their last 10 home games against the Astros following a win.
• The Astros have covered the run line each of their last eight games at Fenway Park against teams that held a winning record.
• The Red Sox have failed to cover the run line in eight of their last nine night games against the Astros at Fenway Park following a win.

Houston Astros Player Prop Facts

• Yordan Alvarez has recorded at least one Double in three of his last four appearances against the Red Sox after not playing the previous day.
• Yordan Alvarez has hit at least one home run in each of the Astros’ last two road games against the Red Sox.
• Jake Meyers has recorded at least one hit in each of his last 16 road appearances against AL opponents.

Boston Red Sox Recap

The Boston Red Sox come into this game looking to build on their 13-1 win over the Twins from their last matchup to sit at 59-51 on the year. After this series, the Red Sox will welcome the Kansas City Royals to town for a series.

Red Sox Win 4 Of Their Last 5

Alex Bregman has 73 hits including 20 doubles along with 14 home runs and 44 RBIs this season. Trevor Story’s added 102 hits with 17 home runs, 65 RBIs and 17 stolen bases while Jarren Duran has 116 hits with 29 doubles, 12 triples, 11 home runs, 60 RBIs and a team-high 18 stolen bases. Kristian Campbell’s added 51 hits with 10 doubles, 6 homers and 21 RBIs while Wilyer Abreu has 20 home runs with 57 RBIs and 6 stolen bases and Ceddanne Rafaela has 14 homers, 21 doubles, 2 triples, 49 RBIs and 14 stolen bases this season.

Why the Boston Red Sox will win

• The Astros have lost 10 of their last 11 night games against American League opponents.
• The Red Sox have won nine of their last 10 games at Fenway Park.
• The Astros have failed to cover the run line in 12 of their last 13 night games against American League opponents.
• The Red Sox have covered the run line in seven of their last eight games following a road win.

Boston Red Sox Player Prop Facts

• Jarren Duran has recorded a Double in four of the Red Sox’s last five games against AL opponents.
• Triston Casas has hit a home run in four of his last five home appearances against AL West opponents.
• Ceddanne Rafaela has recorded at least one hit in each of his 11 previous home appearances against AL West opponents that held a winning record.

Total Runs Facts

• Each of the Red Sox’s last five home games have gone UNDER the total runs line.
• Six of the Astros’ last seven night games against AL East opponents have gone UNDER the total runs line.

Houston Astros vs. Boston Red Sox Prediction

I’m on the Red Sox in this one. I just think that Hunter Brown could struggle in this spot, especially with the Red Sox drumming up a fair amount of offense as of late. Houston is on the road where they’ve been far less effective this season, and this is an Astros team that’s been struggling to begin with in recent games. I’ll side with the Red Sox at home at the nice plus money price in this one.