Sep 6, 2025; Phoenix, Arizona, USA;  Boston Red Sox first base Romy Gonzalez (23) slides into third during the fourth inning between the Arizona Diamondbacks and the Boston Red Sox at Chase Field. Mandatory Credit: Arianna Grainey-Imagn Images

Boston Red Sox vs Arizona Diamondbacks Prediction 9/7/2025 Today’s MLB Picks

Pick details

Boston (78-65) vs Arizona (72-71)

September 7, 2025 at 04:10 PM EDT

The Line: Betting Odds: Arizona -106 — Over/Under: +9

(Get latest betting odds)

In this article, we will formulate a Red Sox vs Diamondbacks Prediction for this MLB game on Sunday, September 7th at the Chase Field in the third game of this series, with the Dbacks having the 2-0 lead. Let’s take a look at the prediction for this MLB matchup.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 72-71 record this season and are sitting on the 4th place of the NL West. The Diamondbacks have a 38-33 home record and are 67-67 in over/under They are coming off a 5-1 home victory over the Red Sox, and are 8-2 in their last 10 games. Under is 6-3-1 in their last 10 games and are playing the Twins and the Giants next.

The Diamondbacks have a .250 batting average this season, .323 OBP and .437 slugging percentage. Arizona’s pitching staff has a 4.43 ERA and 1.32 WHIP. Geraldo Perdomo leads the Diamondbacks with 150 hits, adding a team-high 91 RBI. He is also the team’s best hitter with a .286 batting average. Corbin Carroll leads the team in home runs with 29.

Ryne Nelson (R) is the projected starting pitcher for the Diamondbacks, and he has a 7-3 record, 3.57 ERA and 1.05 WHIP.

Boston Red Sox Preview

The Boston Red Sox have a 78-65 record this season and are sitting on the third place of the AL East. The Red Sox have a 34-37 road record and are 70-70 in over/under. They are coming off a 1-5 road defeat by the Dbacks, and have three consecutive losses. They are 5-2 to the over in their last 7 games and are playing the Athletics and the Yankees next.

The Red Sox have a .254 batting average this season, .324 OBP and .425 slugging percentage. Boston’s pitching staff has a 3.78 ERA and 1.30 WHIP.  Jarren Duran leads the Red Sox with 142 hits, and he is the team’s best hitter, with a .260 batting average. Trevor Story leads the team in RBI, with 88, adding a team-high 23 home runs.

Brayan Bello (R) is the projected starting pitcher for the Red Sox, and he has a 11-6 record, 3.07 ERA and 1.23 WHIP.

Boston Red Sox @ Arizona Diamondbacks Betting Trends: September 7, 2025

  • Probable Starting Pitcher: Ryne Nelson      Record this season: 7-3      ERA: 3.57
  • Home Record: 5-1
  • Last 5 against Red Sox: 1-0

Why the Arizona Diamondbacks will win

  • The Diamondbacks have won seven of their last eight games as underdogs.
  • The Red Sox have lost five of their last six games as favorites against National League opponents.
  • The Diamondbacks have covered the run line in each of their last nine games as underdogs.
  • The Red Sox have failed to cover the run line in seven of their last eight games against the Diamondbacks following a loss.
  • The Diamondbacks have led after 5 innings in each of their last seven home games against AL East opponents.
  • The Diamondbacks have won the first inning in six of their last seven day games at Chase Field.
  • The Diamondbacks have led after 3 innings in seven of their last eight home games.

  • Probable Starting Pitcher: Brayan Bello      Record this season: 11-6      ERA: 3.07
  • Road Record: 3-3
  • Last 5 against Diamondbacks: 0-1

Why the Boston Red Sox will win

  • The Red Sox have won each of their last nine Sunday games as road favorites.
  • The Red Sox have covered the run line in each of their last nine Sunday games as road favorites.
  • The Red Sox have led after 5 innings in five of their last six day games against opponents that held a winning record.

Total Runs Facts

  • Each of the Red Sox’s last five road games after playing the previous day have gone UNDER the total runs line.
  • Six of the Diamondbacks’ last seven games against AL East opponents have gone OVER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Diamondbacks’ last seven day games at Chase Field.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Red Sox’s last five day games against NL West opponents.

Arizona Diamondbacks Player Prop Facts

  • Corbin Carroll has hit a home run in three of the Diamondbacks’ last five games as underdogs.
  • Ryne Nelson has recorded five or more strikeouts in five of his last six home appearances.
  • Corbin Carroll has recorded at least one hit in each of his last 11 appearances against AL East opponents.
  • Ryne Nelson has recorded a win in three of his last four appearances in day games.
  • Corbin Carroll ranks 5th amongst qualified players for Slugging Percentage (.560) this season.

Boston Red Sox Player Prop Facts

  • Trevor Story has hit a home run in each of his last two appearances at Chase Field against opponents that held a winning record.
  • Trevor Story has recorded at least one hit in each of his last nine appearances at Chase Field against opponents that held a winning record.
  • Connor Wong has recorded at least one Double in three of his four previous appearances against the Diamondbacks.

Matchup/League Facts

  • The Diamondbacks rank 2nd in the league for triples this season (34).
  • The Diamondbacks rank 2nd in the league for RBIs this season (689).
  • The Red Sox rank 1st in the league for doubles this season (287).
  • The Red Sox rank 5th in the league for hits this season (1246).

Red Sox vs Diamondbacks Prediction

The Dbacks have won their last six head-to-head meetings against the Red Sox, and both teams are tied 3-3 wins in their last 6 meetings in Arizona.

In this Red Sox vs Diamondbacks Prediction, both teams are coming at a pickem price. Both pitchers have been excellent this season, with a combined 6.64 ERA, and their home/away splits are even better, as Nelson has a 2.60 home ERA and Bello a 2.85 road ERA. Both teams are struggling offensively lately, with the Red Sox having just 7 total runs scored in their last 3 games, and the Dbacks having 5 runs or less in five of their last six games. The total is set at 9, and I don’t think there will be 10 runs scored in this game, so take the under in this one.

Nikos Lagouretos's Pick: Under 9

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