Boston Red Sox vs Arizona Diamondbacks Prediction 9/6/2025 Today’s MLB Picks

The Boston Red Sox and Arizona Diamondbacks meet Saturday in MLB action at Chase Field. Here’s a Boston Red Sox vs Arizona Diamondbacks Prediction. This article will include a Boston Red Sox vs Arizona Diamondbacks Pick.

Boston Red Sox Betting Preview

The Boston Red Sox are 78-64 on the year and play the Athletics, Yankees, and Athletics next. The Boston Red Sox are batting .254 on the season, have a .325 OBP, and a .426 slugging percentage. The Boston Red Sox pitching staff has a 3.78 ERA and a 1.30 WHIP. Jarren Duran leads the Boston Red Sox with 140 hits and 77 RBI, while Trevor Story and Ceddanne Rafaela have combined for 256 hits and 148 RBI.

Lucas Giolito gets the ball for the Boston Red Sox, and he is 10-2 with a 3.38 ERA and 105 strikeouts this season. This will be Giolito’s second career game against the Arizona Diamondbacks.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks are 71-71 on the year and play the Giants, Twins, and Giants next. The Arizona Diamondbacks are batting .250 on the season, have a .323 OBP, and a .438 slugging percentage. The Arizona Diamondbacks pitching staff has a 4.45 ERA and a 1.33 WHIP. Geraldo Perdomo leads the Arizona Diamondbacks with 150 hits and 90 RBI while Corbin Carroll and Lourdes Gurriel Jr. have combined for 253 hits and 154 RBI.

Brandon Pfaadt gets the ball for the Arizona Diamondbacks, and he is 12-8 with a 5.33 ERA and 122 strikeouts this season. This will be Pfaadt’s second career game against the Boston Red Sox.

Boston Red Sox @ Arizona Diamondbacks Betting Trends: September 6, 2025

• Probable Starting Pitcher: Brandon Pfaadt      Record this season: 12-8      ERA: 5.33
• Home Record: 8-3
• Last 5 against Red Sox: 0-1

Why the Arizona Diamondbacks will win

• The underdogs have won each of the last four games between the Red Sox and Diamondbacks.
• The Red Sox have lost four of their last five games as road favorites against NL West opponents.
• The Diamondbacks have covered the run line in 18 of their last 19 games as underdogs following a win.
• The Red Sox have failed to cover the run line in five of their last six road games.
• The Red Sox have trailed after 3 innings in each of their last three games at Chase Field.
• The Red Sox have trailed after 5 innings in each of their last three road games against National League opponents.

• Probable Starting Pitcher: Lucas Giolito      Record this season: 10-2      ERA: 3.38
• Road Record: 5-1
• Last 5 against Diamondbacks: 0-0

Why the Boston Red Sox will win

• The Red Sox have won each of their last six games as road favorites after playing the previous day.
• The Diamondbacks have lost eight of their last nine games as underdogs against American League opponents following a home win.
• The Red Sox have covered the run line in nine of their last 11 night games against NL West opponents following a road loss.
• The Diamondbacks have failed to cover the run line in 16 of their last 21 night games at Chase Field following a home win.

Total Runs Facts

• Each of the Red Sox’s last five road games against National League opponents have gone OVER the total runs line.
• Each of the Diamondbacks’ last five night games against AL East opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Diamondbacks’ last eight home games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Red Sox’s last six games as road favorites against NL West opponents.

Arizona Diamondbacks Player Prop Facts

• Geraldo Perdomo has hit a home run in each of the Diamondbacks’ last two games against the Red Sox.
• Brandon Pfaadt has recorded five or more strikeouts in four of his last five home appearances against opponents that held a winning record.
• Geraldo Perdomo has recorded at least one hit in each of the Diamondbacks’ last nine games as home underdogs.
• Ketel Marte ranks 5th amongst qualified players for On Base Percentage (.390) this season.

Boston Red Sox Player Prop Facts

• Trevor Story has hit a home run in three of the Red Sox’s last four Saturday games as favorites.
• Lucas Giolito has recorded a win in each of his last three appearances with the Red Sox as road favorites.
• Alex Bregman has recorded two hits in three of his last four road appearances against the Diamondbacks.
• Lucas Giolito has recorded seven or more strikeouts in three of his last four appearances with the Red Sox as road favorites.
• Wilyer Abreu has recorded at least one Double in three of his last four appearances with the Red Sox as road favorites.

Matchup/League Facts

• The Diamondbacks rank 2nd in the league for slugging percentage this season (.438).
• The Diamondbacks rank 4th in the league for home runs this season (197).
• The Red Sox rank 4th in the league for batting average this season (.254).
• The Red Sox rank T26th in the league for strikeouts against this season (1253).

Boston Red Sox vs Arizona Diamondbacks Prediction

The Red Sox need to get back on track and this feels like the spot to do it. Giolito has been fantastic this season and that includes allowing 27 hits and 10 runs in his last 37.2 innings. The Red Sox have won 10 of Giolito’s last 12 starts. Sorry if I don’t believe in this recent stretch from the Diamondbacks, and Pfaadt has allowed 45 hits and 21 runs in his last 30.2 innings. Pfaadt has allowed 3 or more earned runs in 5 of his last 7 starts. Give me the Red Sox on Saturday night.