Blue Jays vs Royals Prediction 9/21/2025 Today’s MLB Picks

In this article we will formulate a Blue Jays vs Royals prediction for this MLB game on Sunday, September 21st at Kauffman Stadium in Kansas City, Missouri. Let’s take a look at the prediction for this MLB matchup. 

Toronto Blue Jays Betting Preview

The Toronto Blue Jays are 89-66 this year after they lost the first two games in this series by scores of 1-20 and 1-2. In their game two loss, Toronto scored once in the seventh inning, but that was all of the offense they could find in the defeat. The Blue Jays recorded four hits and they committed two errors in the game, while they were led by Varsho, who went 1-3 with one home run and one RBI in the loss. Toronto started Bieber, who allowed four hits and two earned runs over 6.1 innings for the loss, while Fluharty and Hoffman closed out the game. 

Prior to this series, the Blue Jays split four games with the Rays and swept the Orioles in three games. Toronto has lost four games in a row and they are first in the AL East standings. The Toronto pitching staff has a 4.22 ERA with a 1.27 WHIP and a .241 opponent batting average, while their offense has scored 760 runs with a .266 batting average and a .334 on base percentage this season. Vladimir Guerrero Jr. has led Toronto with 23 home runs and 81 RBIs, while George Springer has added 30 home runs and 79 RBIs this year. The projected starting pitcher for Toronto is Trey Yesavage, who is 0-0 with a 1.80 ERA and a 1.00 WHIP over 5.0 innings pitched this year. 

Kansas City Royals Betting Preview

The Kansas City Royals are 78-77 this season after they won game two by a score of 2-1 on Saturday night. Kansas City scored both of their runs in the fourth inning, which was enough to get the low scoring win. The Royals recorded four hits in the game and they were led by Witt Jr and Pasquantino, who both had one RBI in the win. KC started Cameron, who allowed three hits and one earned run over 6.2 innings for the win, while Estevez picked up the save. 

Prior to this series, the Royals lost two out of three against the Mariners and two out of three against the Phillies. Kansas City has won three of their last four games and they are third in the AL Central standings. The Kansas City pitching staff has a 3.74 ERA with a 1.25 WHIP and a .242 opponent batting average, while the offense has scored 611 runs with a .246 batting average and a .308 on base percentage this season. Vinnie Pasquantino has led KC with 31 home runs and 107 RBIs, while Salvador Perez has added 30 home runs and 95 RBIs this year. The projected starting pitcher for Kansas City is Michael Wacha, who is 9-12 with a 3.79 ERA and a 1.22 WHIP over 161.2 innings pitched this season. 

Why the Blue Jays will beat the Royals 

The Royals have lost five of their last six day games against American League opponents following a win.
The Blue Jays have won five of their last six day games against AL Central opponents following a loss.
The Royals have failed to cover the run line in seven of their last eight day games following a home win.
The Blue Jays have covered the run line in six of their last seven road games against teams that held a winning record.

Total Runs Facts

Five of the Royals’ last six games against AL East opponents have gone OVER the total runs line.
Five of the Blue Jays’ last six games as favorites against AL Central opponents have gone OVER the total runs line.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Blue Jays’ last eight day games against AL Central opponents.
The ‘Inning 1 OVER 0.5 runs’ market has hit in 12 of the Royals’ last 14 games.

Kansas City Royals Player Prop Facts

Michael Massey has hit a home run in three of his last four appearances with the Royals as underdogs against the Blue Jays.
Michael Wacha has recorded three or more strikeouts in 19 of his last 20 appearances against AL East opponents that held a winning record.
Salvador Perez has recorded at least one hit in each of the Royals’ last 13 games as underdogs against the Blue Jays.
Kyle Isbel has recorded at least one Double in three of his last four appearances with the Royals as underdogs against the Blue Jays.
Bobby Witt Jr. ranks 5th in the league in Steals (37) this season.

Toronto Blue Jays Player Prop Facts

Daulton Varsho has hit a home run in five of his last nine road appearances after playing the previous day.
Anthony Santander has recorded at least one hit in each of his 14 previous road appearances against the Royals.
Bo Bichette has recorded a Double in each of his last five road appearances against AL opponents that held a winning record.
George Springer ranks 5th amongst qualified players for Slugging Percentage (.550) this season.

Matchup/League Facts

The Royals rank 28th in the league for runs scored this season (611).
The Royals rank 4th in the league for doubles this season (276).
The Blue Jays rank 1st in the league for on-base percentage this season (.334).
The Blue Jays rank T2nd in the league for doubles this season (280).

Blue Jays vs Royals Prediction 

Toronto comes into this matchup looking to snap their four game losing streak, but they have scored just three runs in those four losses. The Blue Jays are 39-41 on the road this year, while the Royals are 43-37 at home. Kansas City is fighting to finish the season above .500 and they are starting Wacha, who has allowed 7, 1, 4, and 3 earned runs in his last four outings. Toronto is going with Yesavage, who allowed three hits and one earned run in his first start. I don’t like how Toronto is playing, but I am fading Wacha here. Take the Blue Jays to win.