Baltimore Orioles vs Houston Astros Prediction 8/15/2025 Today’s MLB Picks

The Baltimore Orioles and the Houston Astros meet Friday in MLB action from Daikin Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Baltimore Orioles vs. Houston Astros prediction.

Starting Pitching Matchup

The Baltimore Orioles will send out Brandon Young here and Young is 0-6 with a 6.70 ERA and 40 strikeouts this season. This will be Young’s first career start against the Astros. The Houston Astros will start Framber Valdez here and Valdez is 11-5 with a 2.97 ERA and 145 strikeouts this season. In his last five starts against Baltimore, Valdez is 1-1 with a 4.22 ERA and 31 strikeouts.

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to build on their 5-3 win over the Seattle Mariners last time out to improve to 55-66 on the year. After this series, the Orioles will head on the road for a series against the Boston Red Sox.

Orioles Win Back-To-Back Games

Adley Rutschman has 68 hits with 16 doubles, 9 homers and 27 RBIs. Jackson Holliday has 111 hits with 16 doubles, 2 triples, 14 homers and 45 RBIs. Gunnar Henderson has 121 hits with 29 doubles, 4 triples, 14 home runs and 51 RBIs with 16 stolen bases and 106 strikeouts while Holliday has a team-high 111 strikeouts as well this season. Heston Kjerstad’s added 4 homers and 19 RBIs while Jordan Westburg has 14 home runs and 29 RBIs this season.

Why the Baltimore Orioles will win

• The Astros have lost each of their last six games as favorites against American League opponents following a win.
• The underdogs have won 10 of the last 12 games between the Orioles and Astros.
• The Astros have failed to cover the run line each of their last 14 games against American League opponents that held a losing record.
• The Orioles have covered the run line in each of their last seven games as underdogs against American League opponents.

Baltimore Orioles Player Prop Facts

• Jordan Westburg has hit a home run in each of the Orioles’ last two road games against the Astros.
• Gunnar Henderson has recorded a Double in each of the Orioles’ last four games as underdogs against AL West opponents.
• Gunnar Henderson has recorded at least one hit in each of the Orioles’ last nine games against AL West opponents.

Houston Astros Recap

The Houston Astros come into this game looking to add on to their 4-1 win over the Boston Red Sox last time out to sit at 68-53 on the year. After this series, the Astros will head on the road for a series against the Detroit Tigers.

Astros Win Another Series

Jose Altuve has 127 hits including 18 doubles, 21 home runs and 63 RBIs. Jeremy Pena also has 115 hits with 20 doubles, 13 homers and 45 RBIs with 17 stolen bases as well. Jake Meyers has 15 doubles as well and Christian Walker has 16 home runs and 65 RBIs but has also accrued a team-high 127 strikeouts so far this season. Altuve also has 8 stolen bases while Jake Meyers has 14 stolen bases this season. Isaac Paredes also has 19 home runs with 50 RBIs of his own and Cam Smith has contributed 7 homers and 48 RBIs.

Why the Houston Astros will win

• The Orioles have lost each of their last four games at Daikin Park.
• The Astros have won four of their last five games at Daikin Park.
• The Astros have covered the run line in seven of their last eight games against the Orioles.
• The Orioles have failed to cover the run line in each of their last four games against the Astros following a win.

Houston Astros Player Prop Facts

• Yainer Diaz has hit a home run in each of the Astros’ last three games as home favorites.
• Jeremy Pena has recorded at least one Double in each of his last three home appearances against the Orioles.
• Framber Valdez has recorded seven or more strikeouts in each of his last four appearances with the Astros as home favorites against AL opponents.
• Framber Valdez has recorded a win in three of his last four home appearances against AL opponents.
• Jake Meyers has recorded at least one hit in each of his last 10 appearances against AL opponents.
• Jeremy Pena ranks 2nd amongst qualified players for Batting Average (.318) this season.

Total Runs Facts

• Seven of the Orioles’ last eight games have gone UNDER the total runs line.
• Seven of the Astros’ last eight games as favorites against the Orioles have gone OVER the total runs line.

Baltimore Orioles vs. Houston Astros Prediction

I’m on the Astros here. I get the case to be made for an underdog in some spots, but the thing here is that the Orioles are just struggling offensively and Framber Valdez has been far more effective at home this season while Baltimore’s been a different team on the road and not in a good way. Brandon Young is also just not a viable option at the major league level in my opinion, and I think that the Orioles get rung up in this one. Give me Houston big.