Baltimore Orioles vs Chicago White Sox Prediction 9/17/2025 Today’s MLB Picks

The Baltimore Orioles and the Chicago White Sox meet Wednesday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Baltimore Orioles vs. Chicago White Sox prediction.

Starting Pitching Matchup

The Baltimore Orioles will send out Tyler Wells for the start here and Wells is 1-0 with a 2.31 ERA and 10 strikeouts this season. This will be Wells’ second career start against the White Sox. Martin Perez will get the nod for the White Sox here and is 1-5 with a 3.27 ERA and 42 strikeouts this season. In his last five starts against the Orioles, Perez is 0-2 with a 4.33 ERA and 23 strikeouts.

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to add on to their 8-7 win over the White Sox from Tuesday’s matchup to sit at 71-80 this season. After this series, the Orioles will head home for a set against the New York Yankees.

Orioles String Together Back-To-Back Wins

Adley Rutschman has 70 hits with 16 doubles, 9 homers and 29 RBIs. Jackson Holliday has 138 hits with 20 doubles, 3 triples, 17 homers and 55 RBIs. Gunnar Henderson has 143 hits with 32 doubles, 5 triples, 16 home runs and 62 RBIs with 23 stolen bases and 128 strikeouts while Holliday has a team-high 130 strikeouts as well this season. 

Chicago White Sox Recap

The Chicago White Sox come into this game looking to bounce back from their loss to Baltimore on Tuesday to drop to 57-95 this season. After this set, the White Sox will take on the San Diego Padres at home for an interleague series.

White Sox Lose 5 In A Row

Lenyn Sosa has 126 hits including 18 doubles, 20 home runs and 68 RBIs. Andrew Benintendi has 100 hits including 16 doubles, 19 home runs, 60 RBIs and a .241 batting average while Miguel Vargas has 107 hits, 31 doubles, 14 home runs and 53 RBIs. Brooks Baldwin has also added 31 RBIs while Luis Robert Jr. has a team-high 33 stolen bases along with 53 RBIs so far this season. Chase Meidroth has added 108 hits with 13 stolen bases as well as 15 doubles this season.

Baltimore Orioles @ the Chicago White Sox Betting Trends: September 17, 2025

• Probable Starting Pitcher: Martin Perez      Record this season: 1-5      ERA: 3.27
• Home Record: 1-1
• Last 5 against Orioles: 0-1

Why the Chicago White Sox will win

• The Orioles have lost six of their last seven games as road favorites following a road win.
• The underdogs have won three of the White Sox’s last four games at Rate Field.
• The Orioles have failed to cover the run line in each of their last 11 games as favorites following a road win.
• The White Sox have covered the run line in each of their last eight day games at Rate Field following a loss.
• The White Sox have led after 5 innings in each of their last six day games against opponents that held a losing record.
• The White Sox have led after 3 innings in each of their last five day games against opponents that held a losing record.
• The Orioles have lost the first inning in each of their last six road games against opponents that held a losing record.

• Probable Starting Pitcher: Tyler Wells      Record this season: 1-0      ERA: 2.31
• Road Record: 1-0
• Last 5 against White Sox: 0-1

Why the Baltimore Orioles will win

• The Orioles have won each of their last seven road games against the White Sox.
• The White Sox have lost each of their last six home games against the Orioles following a loss.
• The Orioles have covered the run line in 14 of their last 15 games at Rate Field against teams that held a losing record.
• The White Sox have failed to cover the run line in each of their last six home games against the Orioles following a loss.
• The Orioles have led after 5 innings in three of their last four games against the White Sox.
• The Orioles have led after 3 innings in each of their last three day games against AL Central opponents.

Total Runs Facts

• Each of the White Sox’s last nine day games against AL East opponents have gone UNDER the total runs line.
• Each of the Orioles’ last five day games against AL Central opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Orioles’ last seven games as favorites.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the White Sox’s last six home games.

Chicago White Sox Player Prop Facts

• Andrew Benintendi has hit a home run in two of his last three home appearances.
• Martin Perez has recorded five or more strikeouts in each of his last five home appearances against opponents that held a losing record.
• Martin Perez has recorded a win in three of his last four home appearances against opponents that held a losing record.
• Luis Robert has recorded at least one hit in 18 of his last 19 appearances against opponents that held a losing record.

Baltimore Orioles Player Prop Facts

• Colton Cowser has hit a home run in four of the Orioles’ last five games as road favorites against AL opponents.
• Ryan Mountcastle has recorded at least one hit in each of his last 10 road appearances against AL opponents that held a losing record.
• Dylan Carlson has recorded a Double in each of his last three appearances against the White Sox.

Baltimore Orioles vs. Chicago White Sox Prediction

I’m taking the under in this one. I think Tyler Wells is still a solid option for the Orioles going forward and against a White Sox lineup that’s cooled off against righties as of late, I think he can have a solid showing here. On the other side, Martin Perez is a solid lefty in his own right and Baltimore hasn’t been as sharp against lefties in the month of September. I think this is going to be a lower-scoring game because of a lack of offense not necessarily being a pitcher’s duel here so give me the under.