Baltimore Orioles vs Boston Red Sox Prediction 5/23/25 MLB Picks

The Baltimore Orioles and Boston Red Sox meet Friday in a MLB doubleheader at Fenway Park. Here’s a Baltimore Orioles vs Boston Red Sox Prediction. This article will include a Baltimore Orioles vs Boston Red Sox Pick.

Baltimore Orioles Betting Preview

The Baltimore Orioles are 16-32 on the year and play the Cardinals, White Sox, and Mariners next. The Baltimore Orioles are batting .232 on the season, have a .306 OBP, and a .381 slugging percentage. The Baltimore Orioles pitching staff has a 5.45 ERA and a 1.48 WHIP. Gunnar Henderson leads the Baltimore Orioles with 43 hits and 13 RBI, while Ryan O’Hearn and Jackson Holliday have combined for 82 hits and 35 RBI. 

Cade Povich and TBD get the ball for the Baltimore Orioles.

Boston Red Sox Betting Preview

The Boston Red Sox are 25-26 on the year and play the Brewers, Braves, and Angels next. The Boston Red Sox are batting .252 on the season, have a .324 OBP, and a .419 slugging percentage. The Boston Red Sox pitching staff has a 4.03 ERA and a 1.34 WHIP. Alex Bregman leads the Boston Red Sox with 58 hits and 35 RBI, while Jarren Duran and Rafael Devers have combined for 111 hits and 68 RBI.

Brayan Bello and Lucas Giolito get the ball for the Boston Red Sox.

Why the Boston Red Sox will win

• The Orioles have lost each of their last 10 games as underdogs on the first leg of a doubleheader.
• The Red Sox have won each of their last four day games against the Orioles at Fenway Park following a home loss.
• The Orioles have failed to cover the run line in nine of their last 10 games against AL East opponents following a win.
• The Red Sox have covered the run line in each of their last four games against American League opponents following a loss.
• The Orioles have trailed after 5 innings in six of their last seven games as road underdogs.
• The Orioles have trailed after 3 innings in five of their last six games as underdogs.

Why the Baltimore Orioles will win

• The Orioles have won five of their last six games as underdogs after going to extra innings.
• The Red Sox have lost three of their last four games as home favorites against AL East opponents.
• The road team has covered the run line in nine of the Orioles’ last 10 games.
• The Red Sox have failed to cover the run line in each of their last four games as favorites.

Boston Red Sox Player Prop Facts

• Rafael Devers has hit a home run in each of the Red Sox’s last three day games.
• Connor Wong has recorded a Double in three of his last four appearances in day games against teams that held a losing record.
• Alex Bregman has recorded at least one RBI in each of his last four appearances against AL East opponents.
• Trevor Story has recorded at least one Single in each of his last eight appearances in day games against AL teams that held a losing record.
• Jarren Duran has scored at least one run in six of his seven previous appearances with the Red Sox as home favorites against the Orioles.
• Trevor Story has recorded at least one hit in each of his last eight appearances in day games against teams that held a losing record.
• Alex Bregman ranks T10th in the league in Hits (58) this season.

Baltimore Orioles Player Prop Facts

• Ramon Laureano has recorded at least one Double in three of his last four appearances with the Orioles as underdogs against AL opponents.
• Gunnar Henderson has scored at least one run in each of the Orioles’ last four games against AL East opponents.
• Ryan Mountcastle has recorded at least one Single in seven of his last eight appearances against opponents that held a losing record.
• Cedric Mullins has recorded at least one hit in each of the Orioles’ last eight day games against AL East opponents that held a losing record.
• Jordan Westburg has hit a home run in two of his last three road appearances against the Red Sox.
• Dylan Carlson has recorded an RBI in three of his last four appearances against the Red Sox.

Baltimore Orioles vs Boston Red Sox Prediction

Game 1 Prediction: I’ve been fading the Orioles pretty much all season, and there’s no reason to stop now. The Orioles haven’t won two straight games since April 30 – May 2. Povich hasn’t been good with his 5.23 ERA and 1.45 WHIP, and he’s allowed nine hits and seven runs in his last 11.2 innings. Bello was rocked by the Braves in his last start, but he’s a young, promising pitcher who gives the Red Sox a chance to win more times than not. Give me the Red Sox at home with the better pitcher on the mound.  

Game 2 Prediction: The Orioles didn’t announce a starting pitcher at the time this article was published, but it doesn’t matter. As I’ve said before, the Orioles are awful and not a team you should be eager to back. A $100 bettor has lost more than $1,700 this season backing the Orioles. Only the Rockies have lost bettors more money than the Orioles this season. Giolito has been horrendous through 20.1 innings, but it’s the Orioles. Give me the Red Sox to sweep the doubleheader on Friday.