Milwaukee Brewers vs Pittsburgh Pirates Prediction 5/23/25 MLB Picks

The Milwaukee Brewers and the Pittsburgh Pirates meet Friday in MLB action from PNC Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Milwaukee Brewers vs. Pittsburgh Pirates prediction.

Starting Pitching Matchup

The Milwaukee Brewers will send out Freddy Peralta for the start here, and Peralta is 5-3 with a 2.59 ERA and 57 strikeouts this season. In his last five starts against the Pirates, Peralta is 5-3 with a 2.59 ERA and 57 strikeouts. Paul Skenes will get the start for the Pirates and is 3-5 with a 2.44 ERA and 62 strikeouts this season. This will be Skenes’ second career start against the Brewers.

Milwaukee Brewers Recap

The Milwaukee Brewers come into this game looking to build on their 8-5 win over the Pirates from Thursday’s matchup to improve to 25-26 on the year. After this series, the Brewers will head home for an interleague series against the Boston Red Sox.

Brewers Win 4 Of Their Last 5

Brice Turang has 51 hits with 4 home runs, 20 RBIs, and 13 stolen bases, while Jackson Chourio has 53 hits with a team-high 15 doubles, 7 home runs, and 26 RBIs, and Sal Frelick has 46 hits as well as 3 triples and 9 stolen bases so far this season. Christian Yelich also has 8 stolen bases with 9 homers and 30 RBIs while also adding 4 doubles. Yelich also has a team-high 56 strikeouts up to this point in the year. William Contreras has 4 homers and 23 RBIs as well this season. Rhys Hoskins has added 45 hits with 7 home runs, 27 RBIs, and 9 doubles.

Why the Milwaukee Brewers will win

• The Pirates have lost each of their last six games as favorites.
• The Brewers have won 21 of their last 32 games as underdogs against NL Central opponents.
• The Pirates have failed to cover the run line in each of their last seven games as favorites.
• The Brewers have covered the run line in 18 of their last 20 games as road underdogs against NL Central opponents.

Milwaukee Brewers Player Prop Facts

• Christian Yelich has hit at least one home run in three of the Brewers’ last four night games against NL opponents that held a losing record.
• Jackson Chourio has recorded a Double in each of the Brewers’ last four road games against NL Central opponents.
• Freddy Peralta has recorded a win in each of his last three appearances against opponents that held a losing record.
• Christian Yelich has recorded at least one RBI in each of the Brewers’ last five night games against NL teams that held a losing record.
• Jackson Chourio has scored at least one run in eight of the Brewers’ last nine games against NL opponents that held a losing record.
• William Contreras has recorded a Single in each of his last 10 road appearances against NL opponents.
• Freddy Peralta has recorded six or more strikeouts in 12 of his last 13 appearances in night games against NL teams that held a losing record.
• William Contreras has recorded at least one hit in each of his last 13 road appearances against NL opponents.
• Brice Turang ranks T8th in the league in Steals (13) this season.

Pittsburgh Pirates Recap

The Pittsburgh Pirates will be out to bounce back from their series-opening loss to the Brewers on Thursday, falling to 17-34 on the year as a result. After this series, the Pirates will head on the road for a series against the Arizona Diamondbacks.

Pirates Fall Flat In The Opener

Bryan Reynolds has 41 hits with 7 doubles, 6 home runs, and 25 RBIs while also leading the Pirates with 60 strikeouts so far this season. Oneil Cruz has posted a team-high 8 home runs and 19 RBIs with 18 stolen bases, while Isiah Kiner-Falefa has 37 hits with 7 stolen bases. Emmanuel Valdez also has a pair of triples this season. Tommy Pham has 4 doubles and Andrew McCutchen has 35 hits with 7 doubles, and KeBryan Hayes has 44 hits with 15 RBIs and 5 stolen bases.

Why the Pittsburgh Pirates will win

• The Brewers have lost each of their last five night games against the Pirates following a road win.
• The Pirates have won each of their last five night games against the Brewers following a loss.
• The Pirates have covered the run line in nine of their last 10 night games against the Brewers following a loss.
• The Brewers have failed to cover the run line in seven of their last eight games against NL Central opponents following a win.

Pittsburgh Pirates Player Prop Facts

• Bryan Reynolds has hit a home run in each of the Pirates’ last four games as home favorites against NL Central opponents.
• Bryan Reynolds has recorded at least one RBI in each of the Pirates’ last four games as home favorites against NL Central opponents.
• Isiah Kiner-Falefa has recorded at least one Single in each of his last four appearances with the Pirates as favorites.
• Oneil Cruz has scored at least one run in each of his last four home appearances.
• Bryan Reynolds has recorded at least one hit in each of the Pirates’ last nine games as home favorites against NL Central opponents.
• Oneil Cruz ranks 1st in the league in Steals (18) this season.

Total Runs Facts

• Eight of the Pirates’ last nine home games have gone UNDER the total runs line.
• Each of the Brewers’ last four night games as underdogs have gone UNDER the total runs line.

Milwaukee Brewers vs. Pittsburgh Pirates Prediction

I’m on the under here. I get the case to be made for either side in this game, because this is a fantastic starting pitching option. However, these are also two teams that I’ve grown to not really trust as of late at the plate, and like I said, given the starting pitching matchup on both sides, I think we could have a bit of a pitcher’s duel here. Give me the under.