Baltimore Orioles vs Boston Red Sox Prediction 5/22/25 MLB Picks

In this article, we will formulate an Orioles vs Red Sox prediction for this MLB game on Thursday, May 22, at Fenway Park in Boston, Massachusetts. Let’s take a look at the prediction for this MLB matchup.

Baltimore Orioles Betting Preview

The Baltimore Orioles (16-32, 8-17 Away) went through their worst stretch of the season, during which they suffered eight consecutive losses. After being swept by the Twins and Nationals, the Orioles avoided a sweep at the hands of the Milwaukee Brewers with an 8-4 extra-innings win in Game 3. Adley Rutschman led the offense with three RBI, while Tomoyuki Sugano pitched for 6.0 innings in a no-decision, allowing two runs on five hits with three strikeouts and one walk. Bryan Baker was credited with the win.

This season, the Orioles average 3.72 runs per game (25th in the MLB) on a .230/.297/.386 triple-slash. When it comes to pitching, the Orioles’ staff has a 5.53 ERA (28th) and 1.49 WHIP (28th). Cedric Mullins leads the Orioles with a .236 batting average, ten home runs, and 31 RBI this season.

Cade Povich will take the mound for the Orioles on Thursday. The 25-year-old left-hander has a 1-3 record in eight starts this year with a 5.23 ERA and 1.45 WHIP in 41.1 innings.

Boston Red Sox Betting Preview

The Boston Red Sox (25-26, 14-12 Home) were swept by the Detroit Tigers and lost the series to the Atlanta Braves, but beat the New York Mets in a three-game series at home. The Red Sox failed to get a sweep, though, as the Mets celebrated a 5-1 victory in Game 3. Garrett Crochet pitched for 5.1 innings in a no-decision, allowing one run on five hits with five strikeouts and one walk. Liam Hendriks took the loss.

This year, the Red Sox average 4.78 runs per game (8th in the MLB) on a .253/.325/.423 triple-slash. When it comes to pitching, the Red Sox’s staff has a 4.01 ERA (17th) and 1.33 WHIP (21st). Rafael Devers leads the Red Sox with a .287 batting average, ten home runs, and 39 RBI this season.

The projected starting pitcher for the Red Sox is Lucas Giolito, who is 1-1 in four starts this season, with a 7.08 ERA and 1.52 WHIP in 20.1 innings.

Total Runs Facts

• Seven of the Orioles’ last eight games following an extra innings win have gone OVER the total runs line.
• Each of the Red Sox’s last five home games against AL East opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Orioles’ last four road games against American League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in four of the Red Sox’s last five games as home favorites.

Matchup/League Facts

• The Red Sox rank 28th in the league for hits allowed this season (450).
• The Red Sox are one of only four teams in the league to rank top 10 in both steals and batting average this season.
• The Orioles rank 28th in the league for ERA this season (5.45).
• The Orioles rank 27th in the league for walks this season (134).

Orioles vs Red Sox Prediction

The Red Sox won six of the previous ten H2H encounters, including three of the last four. They already faced this season, and Boston won two of three games, while two of three went Over. Seven of Baltimore’s previous ten games went Over, and I am backing another one on Thursday. I don’t trust Povich and Giolito, and expect each offense to score 3+ runs in the opening five innings. Giolito allowed 13 runs in his last three starts, while Povich surrendered ten runs in his previous three starts. Povich faced the Red Sox this year and allowed three runs in 4.1 innings. Go with Over.