Cleveland Guardians vs Detroit Tigers Prediction 5/22/25 MLB Picks

The Cleveland Guardians and Detroit Tigers meet Thursday in MLB action at Comerica Park. Here’s a Cleveland Guardians vs Detroit Tigers Prediction. This article will include a Cleveland Guardians vs Detroit Tigers Pick.

Cleveland Guardians Betting Preview

The Cleveland Guardians are 26-22 on the year and play the Dodgers, Angels, and Yankees next. The Cleveland Guardians are batting .234 on the season, have a .307 OBP, and a .382 slugging percentage. The Cleveland Guardians’ pitching staff has a 4.12 ERA and a 1.41 WHIP. Steven Kwan leads the Cleveland Guardians with 60 hits and 17 RBI, while Jose Ramirez and Carlos Santana have combined for 89 hits and 48 RBI. 

Tanner Bibee gets the ball for the Cleveland Guardians, and he is 3-4 with a 4.06 ERA and 35 strikeouts this season. Bibee is 1-3 with a 5.28 ERA and 27 strikeouts in his career against the Detroit Tigers.

Detroit Tigers Betting Preview

The Detroit Tigers are 33-17 on the year and play the Giants, Royals, and White Sox next. The Detroit Tigers are batting .259 on the season, have a .331 OBP, and a .421 slugging percentage. The Detroit Tigers’ pitching staff has a 3.32 ERA and a 1.17 WHIP. Riley Greene leads the Detroit Tigers with 54 hits and 34 RBI, while Kerry Carpenter and Zach McKinstry have combined for 91 hits and 39 RBI.

Jack Flaherty gets the ball for the Detroit Tigers, and he is 2-5 with a 4.44 ERA and 56 strikeouts this season. Flaherty is 2-2 with a 1.96 ERA and 36 strikeouts in his career against the Cleveland Guardians.

Why the Detroit Tigers will win

• The Tigers have won each of their last six home games following a road win.
• The Guardians have lost five of their last six road games against American League opponents following a win.
• The Tigers have covered the run line in each of their last eight night games against AL Central opponents following a win.
• The Guardians have failed to cover the run line in six of their last seven games as road underdogs against the Tigers following a win.
• The Guardians have lost the first inning in three of their last four games at Comerica Park against AL Central opponents that held a winning record.
• The Tigers have led after 5 innings in each of their last three games as favorites.
• The Guardians have trailed after 3 innings in each of their last four games as underdogs against American League opponents.

Why the Cleveland Guardians will win

• The Guardians have won seven of their last eight night games against AL Central opponents.
• The Tigers have lost four of their last five night games against the Guardians following a road win.
• The Tigers have failed to cover the run line in each of their last seven games against American League opponents following a win.
• The underdogs have covered the run line in nine of the Tigers’ last 10 games.

Detroit Tigers Player Prop Facts

• Riley Greene has hit a home run in three of the Tigers’ last four night games.
• Riley Greene has recorded a Double in three of the Tigers’ last four games against AL opponents.
• Spencer Torkelson has recorded at least one RBI in six of the Tigers’ last seven home games against AL Central opponents.
• Jack Flaherty has recorded a win in each of his last four appearances with his team as a favorite against AL Central opponents.
• Gleyber Torres has scored at least one run in seven of his last eight home appearances against AL opponents that held a winning record.
• Jack Flaherty has recorded six or more strikeouts in each of his last five appearances with his team as a favorite.
• Zach McKinstry has recorded at least one Single in each of his last seven appearances at Comerica Park against opponents that held a winning record.
• Parker Meadows has recorded at least one hit in each of his last 11 appearances in night games against AL teams that held a winning record.
• Spencer Torkelson ranks T9th in the league in Home Runs (12) this season.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit at least one home run in three of the Guardians’ last four games against the Tigers at Comerica Park.
• Carlos Santana has recorded at least one RBI in six of the Guardians’ last seven road games.
• Jose Ramirez has scored a run in each of the Guardians’ last four games against AL Central opponents.
• Steven Kwan has recorded at least one Single in each of the Guardians’ last seven games against AL Central opponents that held a winning record.
• Steven Kwan has recorded at least one hit in each of the Guardians’ last 13 games against AL opponents that held a winning record.
• Steven Kwan ranks 7th amongst qualified players for Batting Average (.317) this season.

Cleveland Guardians vs Detroit Tigers Prediction

These are two capable offenses and two pitchers who have struggled to find their form, so I’m going with the over in this spot. Bibee has a 4.06 ERA and 1.29 WHIP on the season, and through 26.1 road innings, he has a 6.49 ERA and .292 allowed batting average. Flaherty has allowed 17 hits and 11 earned runs in his last 14.1 innings. The Tigers have lost six of the last seven games Flaherty has pitched. I expect a high score on Thursday night. Give me the over.