Los Angeles Angels vs Oakland Athletics Prediction 5/22/25 MLB Picks

The Los Angeles Angels are visiting the Athletics on Thursday, May 22nd at the Sutter Health Park in the third game of this series, with the Angels having a 3-0 lead. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Angels vs Athletics Prediction. We will examine:

The Athletics’ recent form and player performance

The Los Angeles Angels’ recent form and player performance

Recent betting trends and streaks involving the Athletics

Recent betting trends and streaks involving the Los Angeles Angels

Recent betting trends in games played between the Los Angeles Angels and the Athletics

A summary that ties it all together and produces a favorable betting outcome for the Los Angeles Angels vs Athletics game

Athletics Preview

The Athletics have a 22-28 record this season and are sitting in 4th place in the AL West. The Athletics have an 8-16 home record and are 26-20 in over/under. They are coming off a 5-10 home defeat by the Athletics, and are 2-12 in their last 14 games. Over is 6-1 in their last 6 home games, and they are playing the Phillies and the Astros next.

The Athletics have a .253 batting average this season, a .315 OBP, and a .417 Slugging percentage. Athletics’ pitching staff has a 5.23 ERA and 1.49 WHIP. Jacob Wilson leads the Athletics with 62 hits and a team-high .341 batting average, while Tyler Soderstrom leads the team with 30 RBI, and Brent Booker adds a team-high 10 home runs.

Luis Severino (R) will take the mound for the Athletics, and he has a 1-4 record, 4.22 ERA, and 1.27 WHIP. He has been weaker at home with a 6.75 ERA across six home starts, and he is coming off a shutout start across 6 innings pitched against the Giants. Luis Severino is 0-1 with an ERA of 3.10 and 25 strikeouts in 5 appearances versus the Angels in his career.

Los Angeles Angels Preview

The Los Angeles Angels have a 23-25 record this season and are sitting in last place in the AL West. The Angels have a 14-15 road record and 28-20 in over/under. They are coming off a 10-5 road victory over the Athletics and have six consecutive wins. Over is 7-3 in their last 10 games, and they are playing the Marlins and the Yankees next.

The Angels have a .225 batting average this season, a .286 OBP, and a .413 Slugging percentage. LA’s pitching staff has a 5.01 ERA and 1.50 WHIP. Nolan Schanuel leads the Angels with 44 hits, and he is the team’s best hitter with a .277 batting average. Taylor Ward leads the team with 29 RBI and a team-high 13 home runs.

Tyler Anderson (L) will take the mound for the Angels, and he has a 2-1 record, 3.04 ERA, and 1.09 WHIP. He has been weaker on the road with a 3.74 ERA across four road starts, and he has given up 2+ runs in four of his last five starts. Tyler Anderson is 4-1 with an ERA of 2.48 and 34 strikeouts in 7 appearances against the Oakland Athletics in his career.

Why the Athletics will win

• The Angels have lost each of their last six day games against American League opponents.
• The Athletics have won four of their last five day games following a home loss.
• The Athletics have covered the run line in each of their last nine Thursday day games against the Angels.
• The Angels have failed to cover the run line in each of their last six day games against American League opponents.
• The Angels have trailed after 3 innings in 10 of their last 11 day games against AL West opponents.
• The Angels have trailed after 5 innings in seven of their last eight day games against AL West opponents that held a losing record.

Why the Los Angeles Angels will win

• The Athletics have lost each of their last nine games after playing the previous day.
• The Angels have won each of their last six games as underdogs.
• The Athletics have failed to cover the run line each of their last 10 home games against teams that held a losing record.
• The Angels have covered the run line in each of their last six games.
• The Angels have led after 5 innings in each of their last six games.
• The Angels have won the first inning in three of their last four day games.
• The Angels have led after 3 innings in five of their last six games.

Total Runs Facts

• Each of the Angels’ last four day games after playing the previous day have gone OVER the total runs line.
• Six of the Athletics’ last seven home games have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Angels’ last nine day games against American League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the Athletics’ last six home games.

Matchup/League Facts

• The Athletics rank 30th in the league for walks allowed this season (197).
• The Athletics rank 29th in the league for hits allowed this season (466).
• The Angels rank 30th in the league for walks this season (121).
• The Angels rank 29th in the league for steals this season (23).

Los Angeles Angels vs Athletics Prediction

The Angels are 4-0 in their last 4 meetings against the A’s, but the Athletics are 8-5 in their last 13 overall meetings, and are 5-4 in their last 9 meetings in Oakland. Over is 7-3 in their last 10 meetings.

In this Los Angeles Angels vs Athletics Prediction, the Athletics are coming as -155 home favorites. With yesterday’s win, the Angels now have a better record than the Athletics, and they have six more wins on the road than the Athletics have at home. Tyler Anderson has been better than Severino, and the Athletics are weaker against lefties, so the A’s are clearly overvalued in this spot.

Only concern for the Angels is their league-worst bullpen, so we will take a look at the first 5 innings of this game to eliminate that. Angels are underdogs in the first 5 innings as well, so we can take them at +0.5, which offers huge value. Ride the hot hand and take the Los Angeles Angels at +0.5 in the first 5 innings in this one.