Aug 18, 2025; Boston, Massachusetts, USA; Baltimore Orioles first baseman Ryan Mountcastle (6) and Baltimore Orioles shortstop Luis Vazquez (52) celebrate after defeating the Boston Red Sox at Fenway Park. Mandatory Credit: Paul Rutherford-Imagn Images

Baltimore Orioles vs Boston Red Sox Prediction 8/19/2025 Today’s MLB Picks

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Baltimore (58-67) vs Boston (68-58)

August 19, 2025 at 07:10 PM EDT

The Line: Betting Odds: Boston -1.5 — Over/Under: +9.5

(Get latest betting odds)

The Baltimore Orioles and Boston Red Sox meet Tuesday in MLB action at Fenway Park. Here’s a Baltimore Orioles vs Boston Red Sox Prediction. This article will include a Baltimore Orioles vs Boston Red Sox Pick.

Baltimore Orioles Betting Preview

The Baltimore Orioles are 58-67 on the year and play the Astros, Red Sox, and Giants next. The Baltimore Orioles are batting .241 on the season, have a .306 OBP, and a .405 slugging percentage. The Baltimore Orioles pitching staff has a 4.68 ERA and a 1.38 WHIP. Gunnar Henderson leads the Baltimore Orioles with 124 hits and 57 RBI, while Jackson Holliday and Jordan Westburg have combined for 193 hits and 82 RBI. 

Tomoyuki Sugano gets the ball for the Baltimore Orioles, and he is 10-5 with a 4.13 ERA and 82 strikeouts this season. This will be Sugano’s first career game against the Boston Red Sox.

Boston Red Sox Betting Preview

The Boston Red Sox are 68-58 on the year and play the Yankees, Orioles, and Pirates next. The Boston Red Sox are batting .253 on the season, have a .323 OBP, and a .426 slugging percentage. The Boston Red Sox pitching staff has a 3.76 ERA and a 1.30 WHIP. Jarren Duran leads the Boston Red Sox with 129 hits and 69 RBI while Trevor Story and Ceddanne Rafaela have combined for 228 hits and 131 RBI.

Walker Buehler gets the ball for the Boston Red Sox, and he is 7-7 with a 5.43 ERA and 78 strikeouts this season. Buehler is 1-1 with a 2.16 ERA and 18 strikeouts in his career against the Baltimore Orioles.

Why the Boston Red Sox will win

  • The Red Sox have won 20 of their last 24 home games after playing the previous day.
  • The Orioles have lost three of their last four road games following a road win.
  • The Red Sox have covered the run line in five of their last six home games following a home loss.

Why the Baltimore Orioles will win

  • The underdogs have won each of the Orioles’ last four games at Fenway Park.
  • The Red Sox have lost three of their last four games as home favorites after playing the previous day.
  • The underdogs have covered the run line in each of the Orioles’ last 11 games.
  • The Red Sox have failed to cover the run line in eight of their last nine games as home favorites against AL East opponents.
  • The Red Sox have trailed after 3 innings in four of their last five night games.
  • The Orioles have led after 5 innings in six of their last seven games against AL East opponents.

Boston Red Sox Player Prop Facts

  • Ceddanne Rafaela has hit a home run in three of the Red Sox’s last six home games against AL opponents that held a losing record.
  • Jarren Duran has recorded at least one hit in each of the Red Sox’s last nine night games against AL opponents that held a losing record.
  • Jarren Duran has recorded a Double in five of the Red Sox’s last six games against AL opponents that held a losing record.

Baltimore Orioles Player Prop Facts

  • Tyler O’Neill has hit a home run in three of his last five appearances in night games.
  • Ryan Noda has recorded at least one hit in each of his last seven appearances with his team as an underdog against the Red Sox.

Baltimore Orioles vs Boston Red Sox Prediction

The Red Sox should be favored at home given they’re the better team, but Buehler has been a mess this season with a 5.43 ERA and 1.55 WHIP. The Orioles are putting together one of their better weeks of the season and Sugano has allowed 17 hits and six runs in his last 23.1 innings. Sugano has allowed one run in three of his last four starts. The Orioles have been making bettors money as of late and with the pitching edge, I’ll side with them on Tuesday night.

Randy Chambers's Pick: Baltimore Orioles

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