Cardinals vs Cubs Prediction 9/27/25 MLB Picks Today

In this article, we will formulate a Cardinals vs Cubs Prediction for this MLB game on Saturday, September 27th at the Wrigley Field in the second game of this series, with the Cubs having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Chicago Cubs Preview

The Chicago Cubs have a 90-70 record this season and are sitting on the second place of the NL Central. The Cubs have a 48-31 home record and are 73-74 in over/under. They are coming off a 12-1 home win over the Cardinals, but are 2-6 in their last 8 games. Over is 5-1-1 in their last 7 games.

The Cubs have a .249 batting average this season, .321 OBP and .429 Slugging percentage. Chicago’s pitching staff has a 3.82 ERA and 1.18 WHIP. Nico Hoerner leads the Cubs with 177 hits, and he is the team’s best hitter with a .300 batting average. Seiya Suzuki leads the team in RBI, with 101, while Michael Busch adds a team-high 32 home runs.

Jameson Taillon (R) is the projected starting pitcher for the Cubs, and he has a 10-7 record, 3.78 ERA and 1.07 WHIP.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 78-82 record this season and are sitting on the 4th place of the NL Central. The Cardinals have a 34-44 road record and are 80-72 in over/under. They are coming off a 1-12 road defeat by the Cubs, and have back-to-back losses. Under is 5-3 in their last 8 games.

The Cardinals have a .246 batting average this season, .315 OBP and .379 Slugging percentage. Saint Louis’ pitching staff has a 4.28 ERA and 1.32 WHIP. Alec Burleson leads the Cardinals with 144 hits, and he is the team’s best hitter with a .292 batting average. Wilson Contreras leads the team in RBI, with 80, adding a team-high 20 home runs.

Michael McGreevy (R) is the projected starting pitcher for the Cardinals, and he has an 8-3 record, 4.35 ERA and 1.23 WHIP.

St. Louis Cardinals @ the Chicago Cubs Betting Trends: September 27, 2025

• Probable Starting Pitcher: Jameson Taillon      Record this season: 10-7      ERA: 3.78
• Home Record: 4-2
• Last 5 against Cardinals: 1-2

Why the Chicago Cubs will win

• The Cubs have won each of their last six games against NL Central opponents that held a losing record.
• The Cardinals have lost seven of their last eight games at Wrigley Field against teams that held a winning record.
• The Cubs have covered the run line each of their last six games against National League opponents that held a losing record.
• The Cardinals have failed to cover the run line in seven of their last eight games at Wrigley Field against teams that held a winning record.
• The Cubs have won the first inning in each of their last three games against opponents that held a losing record.
• The Cubs have led after 3 innings in seven of their last eight games as home favorites against National League opponents.
• The Cardinals have trailed after 5 innings in eight of their last nine road day games.

• Probable Starting Pitcher: Michael McGreevy      Record this season: 8-3      ERA: 4.35
• Road Record: 5-0
• Last 5 against Cubs: 1-0

Why the St. Louis Cardinals will win

• The Cubs have lost seven of their last eight games as favorites against the Cardinals following a home win.
• The underdogs have won four of the Cardinals’ last five games.
• The Cubs have failed to cover the run line in each of their last nine games as home favorites following a home win.
• The Cardinals have covered the run line in seven of their last eight games as underdogs after playing the previous day.
• The Cardinals have led after 5 innings in five of their last six games against opponents that held a winning record.
• The Cardinals have led after 3 innings in seven of their last eight Saturday day games against NL Central opponents that held a winning record.

Total Runs Facts

• Seven of the Cubs’ last eight home games have gone OVER the total runs line.
• Each of the Cardinals’ last four day games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cardinals’ last four games at Wrigley Field.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the last four day games between the Cardinals and Cubs at Wrigley Field.

Chicago Cubs Player Prop Facts

• Ian Happ has recorded a Double in three of the Cubs’ last four games.
• Seiya Suzuki has hit a home run in three of the Cubs’ last four home games against the Cardinals.
• Jameson Taillon has recorded a win in each of his last seven appearances in day games against teams that held a losing record.
• Ian Happ has recorded at least one hit in each of the Cubs’ last nine games as favorites.
• Nico Hoerner ranks 5th in the league in Hits (177) this season.

St. Louis Cardinals Player Prop Facts

• Nolan Gorman has hit a home run in three of the Cardinals’ last four Saturday day games as underdogs.
• Brendan Donovan has recorded at least one hit in each of his last eight appearances.
• Brendan Donovan has recorded at least one Double in four of his last five appearances.
• Victor Scott II ranks T10th in the league in Steals (33) this season.

Matchup/League Facts

• The Cubs rank 1st in the league for walks allowed this season (401).
• The Cubs rank 3rd in the league for steals this season (160).
• The Cardinals rank 30th in the league for triples this season (8).
• The Cardinals rank 29th in the league for home runs this season (146).

Cardinals vs Cubs Prediction

The Cubs are 6-3 in their last 9 head-to-head meetings against the Cardinals, and are 3-1 in their last 4 meetings in Chicago. Over is 5-2 in their last 7 meetings.  

In this Cardinals vs Cubs Prediction, the Cubs are coming as -180 home favorites. Taillon has been outstanding for the Cubs lately, with a 2.00 ERA across his last 5 starts, while McGreevy has been unstable for the Cardinals, and had 5 earned runs in his last start. Chicago also has the 5th-best offense in baseball and I expect them to get the job done today at home, as they start rolling towards the upcoming postseason.