Athletics vs Minnesota Twins Prediction 8/21/2025 Today’s MLB Picks

The Athletics and Minnesota Twins meet Thursday in MLB action at Target Field. Here’s a Athletics vs Minnesota Twins Prediction. This article will include a Athletics vs Minnesota Twins Pick.

Athletics Betting Preview

The Athletics are 58-70 on the year and play the Mariners, Tigers, and Rangers next. The Athletics are batting .254 on the season, have a .319 OBP, and a .428 slugging percentage. The Athletics pitching staff has a 4.84 ERA and a 1.38 WHIP. Brent Rooker leads the Athletics with 135 hits and 72 RBI, while Tyler Soderstrom and Jacob Wilson have combined for 236 hits and 119 RBI. 
Jack Perkins gets the ball for the Athletics, and he is 2-2 with a 4.28 ERA and 35 strikeouts this season. This will be Perkins’ first career game against the Minnesota Twins.

Minnesota Twins Betting Preview

The Minnesota Twins are 58-68 on the year and play the White Sox, Blue Jays, and Padres next. The Minnesota Twins are batting .238 on the season, have a .309 OBP, and a .396 slugging percentage. The Minnesota Twins pitching staff has a 4.22 ERA and a 1.28 WHIP. Byron Buxton leads the Minnesota Twins with 99 hits and 61 RBI while Trevor Larnach and Brooks Lee have combined for 191 hits and 103 RBI.

Jose Urena gets the ball for the Minnesota Twins, and he is 0-0 with a 4.06 ERA and 17 strikeouts this season. Urena is 3-1 with a 3.74 ERA and 23 strikeouts in his career against the Athletics.

Why the Minnesota Twins will win

The underdogs have won each of the Twins’ last four games at Target Field.
The Athletics have lost seven of their last eight day games following an extra innings win.
The Twins have covered the run line in nine of their last 10 games as underdogs against AL West opponents.
The Athletics have failed to cover the run line in 10 of their last 12 games as favorites against American League opponents.
The Athletics have trailed after 5 innings in each of their last four day games against AL Central opponents.

Why the Athletics will win

The Athletics have won seven of their last eight games at Target Field against AL Central opponents that held a losing record.
The Twins have lost seven of their last eight games after going to extra innings.
The Athletics have covered the run line in each of their last 10 day games against the Twins at Target Field following a win.
The Twins have failed to cover the run line in each of their last nine day games against the Athletics at Target Field following a home loss.
The Twins have trailed after 3 innings in four of their last five games against American League opponents.
The Twins have trailed after 5 innings in seven of their last eight Thursday games against opponents that held a losing record.

Minnesota Twins Player Prop Facts

Trevor Larnach has hit a home run in two of the Twins’ last three games as home underdogs against AL West opponents.
Trevor Larnach has recorded at least one hit in 13 of his last 14 appearances at Target Field against AL West opponents that held a losing record.

Athletics Player Prop Facts

Shea Langeliers has hit a home run in four of the Athletics’ last five games against AL Central opponents.
Nick Kurtz has recorded two Doubles in three of the Athletics’ last four road games against AL Central opponents.
Zack Gelof has recorded at least one hit in each of his last six appearances with the Athletics as favorites against AL Central opponents.
Shea Langeliers ranks T10th in the league in Home Runs (28) this season.

Athletics vs Minnesota Twins Prediction

I’m not running to the window to back Perkins, who has allowed 13 hits and 10 runs in his last 14 innings. However, Perkins has a 2.08 ERA and .123 allowed batting average in 17.1 road innings. The Twins are free-falling and Urena is a journeyman who struggles with control and when he gets hit he gets hit hard. Urena has been solid in 12.2 innings since coming over from the Dodgers, but I don’t trust it. I also don’t trust the Twins. Give me the A’s.