Athletics vs Arizona Diamondbacks Prediction 7/22/2026 Today’s MLB Picks

The Athletics and Arizona Diamondbacks meet Wednesday in MLB action at Chase Field. Here’s an Athletics vs Arizona Diamondbacks Prediction. This article will include an Athletics vs Arizona Diamondbacks Pick.

Athletics Betting Preview

The Athletics are 43-58 on the year and play the Twins and Red Sox next. The Athletics are batting .247 on the season, have a .324 OBP, and have a .407 slugging percentage. The Athletics’ pitching staff has a 5.29 ERA and a 1.48 WHIP. Shea Langeliers leads the Athletics with 96 hits and 51 RBI, while Nick Kurtz and Tyler Soderstrom have combined for 168 hits and 113 RBI.

Gage Jump gets the ball for the Athletics, and he is 3-5 with a 3.78 ERA and 56 strikeouts this season. This will be Jump’s first career game against the Arizona Diamondbacks.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks are 52-49 on the year and play the Cardinals and Nationals next. The Arizona Diamondbacks are batting .238 on the season, have a .308 OBP, and have a .386 slugging percentage. The Arizona Diamondbacks’ pitching staff has a 4.21 ERA and a 1.28 WHIP. Ketel Marte leads the Arizona Diamondbacks with 100 hits and 58 RBI, while Corbin Carroll and Geraldo Perdomo have combined for 170 hits and 83 RBI.

Merrill Kelly gets the ball for the Arizona Diamondbacks, and he is 7-8 with a 5.20 ERA and 62 strikeouts this season. Kelly is 2-1 with a 3.93 ERA and 18 strikeouts in his career against the Athletics.

Why the Arizona Diamondbacks will win

• The Athletics have lost nine of their last 10 road games.
• The Diamondbacks have won seven of their last eight games after playing the previous day.
• The Diamondbacks have covered the run line in eight of their last nine day games against AL West opponents.
• The Athletics have failed to cover the run line in seven of their last eight games as underdogs following a road loss.
• The Athletics have trailed after 5 innings in eight of their last 10 games as road underdogs.
• The Athletics have trailed after 3 innings in three of their last four day games against opponents that held a winning record.

Why the Athletics will win

• The Athletics have won four of their last five games as road underdogs against National League opponents following a road loss.
• The Diamondbacks have lost three of their last four games as home favorites against American League opponents.
• The Diamondbacks have failed to cover the run line in each of their last six games against American League opponents after playing the previous day.
• The road team has covered the run line in eight of the Diamondbacks’ last nine games.

Total Runs Facts

• Each of the Diamondbacks’ last four home games after going to extra innings have gone UNDER the total runs line.
• Nine of the Athletics’ last 12 games as underdogs against the Diamondbacks have gone UNDER the total runs line.
• There has been no run scored during the first inning in seven of the last eight day games between the Athletics and Diamondbacks.
• There has been no run scored during the first inning in five of the Athletics’ last six road games against National League opponents.

Arizona Diamondbacks Player Prop Facts

• Merrill Kelly has recorded four or more strikeouts in each of his last 10 appearances at Chase Field against opponents that held a losing record.
• Max Kepler has hit a home run in each of his last three home appearances against AL opponents that held a losing record.
• Ildemaro Vargas has recorded at least one hit in each of his last nine appearances against the Athletics.

Athletics Player Prop Facts

• Jacob Wilson has hit a home run in three of the Athletics’ last four games as underdogs.
• Gage Jump has recorded five or more strikeouts in six of his last seven appearances.
• Joshua Kuroda-Grauer has recorded at least one hit in each of his last eight appearances against opponents that held a winning record.

Matchup/League Facts

• The Diamondbacks rank 2nd in the league for triples this season (22).
• The Diamondbacks rank 2nd in the league for triples this season (22).
• The Athletics rank 29th in the league for ERA this season (5.29).
• The Athletics rank 29th in the league for ERA this season (5.29).

Athletics vs Arizona Diamondbacks Prediction

I’m not thrilled to get behind Kelly, and his 5.20 ERA and 1.49 WHIP, but the Diamondbacks are playing the better baseball, and they’re at home with the quick turnaround. The A’s are a talented lineup, but they’ve also had issues producing on a consistent level, so it might not even matter. Also, Jump is still a rookie with just 52.1 innings under his belt. I’ll side with the Diamondbacks and the cheap price at home.

Randy Chambers's Pick: Arizona Diamondbacks