Arizona Diamondbacks vs San Francisco Giants Prediction 9/9/2025 Today’s MLB Picks

In this article, we will formulate a Diamondbacks vs Giants Prediction for this MLB game on Tuesday, September 9th at the Oracle Park in the second game of this series, with the Giants having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

San Francisco Giants Preview

The San Francisco Giants have a 73-71 record this season and are sitting on the third place of the NL West. They have a 36-34 home record and are 68-70 in over/under. They are coming off a 11-5 home victory over the Giants, that ended their two-game losing streak. Over is 7-3 in their last 10 games and are playing the Dodgers and the Diamondbacks next.

The Giants have a .240 batting average this season, .314 OBP and .393 Slugging percentage. San Francisco’s pitching staff has a 3.75 ERA and 1.29 WHIP.  Heliot Ramos leads the Giants with 146 hits, while Jung Hoo Lee is the team’s best hitter, with a .271 batting average. Willy Adames leads the team in RBI with 78, adding a team-high 27 home runs. 

Robbie Ray (L) is the projected starting pitcher for the Giants, and he has a 10-6 record, 3.31 ERA and 1.18 WHIP.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 72-73 record this season and are sitting on the 4th place of the NL West. The Diamondbacks have a 34-39 road record and are 69-67 in over/under They are coming off a 5-11 road defeat by the Giants, and have back-to-back losses. Over is 3-1 in their last 4 games and are playing the Twins and the Giants next.

The Diamondbacks have a .250 batting average this season, .322 OBP and .435 slugging percentage. Arizona’s pitching staff has a 4.48 ERA and 1.32 WHIP. Geraldo Perdomo leads the Diamondbacks with 150 hits, adding a team-high 91 RBI. Ketel Marte is the team’s best hitter with a .287 batting average, while Corbin Carroll leads the team in home runs with 29.

Zac Gallen (R) is the projected starting pitcher for the Diamondbacks, and he has a 11-13 record, 4.77 ERA and 1.28 WHIP.

Arizona Diamondbacks @ San Francisco Giants Betting Trends: September 9, 2025

• Probable Starting Pitcher: Robbie Ray      Record this season: 10-6      ERA: 3.31
• Home Record: 4-3
• Last 5 against Diamondbacks: 2-0

Why the San Francisco Giants will win

• The Giants have won each of their last nine games as home favorites against NL West opponents following a home win.
• The Diamondbacks have lost seven of their last eight Tuesday games at Oracle Park.
• The Giants have covered the run line in eight of their last nine night games against National League opponents.
• The Diamondbacks have failed to cover the run line in each of their last four games at Oracle Park.
• The Giants have won the first inning in five of their last six home games.
• The Giants have led after 3 innings in seven of their last eight home games against NL West opponents that held a losing record.
• The Giants have led after 5 innings in 12 of their last 13 home games against NL West opponents that held a losing record.

• Probable Starting Pitcher: Zac Gallen      Record this season: 11-13      ERA: 4.77
• Road Record: 7-6
• Last 5 against Giants: 4-1

Why the Arizona Diamondbacks will win

• The Diamondbacks have won four of their last five games as underdogs against NL West opponents following a road loss.
• The Giants have lost seven of their last eight Tuesday games as home favorites against National League opponents.
• The Giants have failed to cover the run line in each of their last nine Tuesday games as home favorites.
• The Diamondbacks have covered the run line in 12 of their last 13 games as underdogs against the Giants following a road loss.
• The Diamondbacks have led after 3 innings in four of their last five games.
• The Diamondbacks have led after 5 innings in four of their last five games.

Total Runs Facts

• Each of the last four games between the Diamondbacks and Giants have gone OVER the total runs line.
• Three of the Diamondbacks’ last four games have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Giants’ last eight home games against NL West opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Diamondbacks’ last four night games against National League opponents.

San Francisco Giants Player Prop Facts

• Jung Hoo Lee has hit a home run in each of the Giants’ last three home games against the Diamondbacks.
• Willy Adames has recorded at least one Double in each of his last five home appearances against the Diamondbacks.
• Dominic Smith has recorded at least one hit in each of his last 20 appearances in night games.
• Rafael Devers ranks 9th amongst qualified players for On Base Percentage (.378) this season.

Arizona Diamondbacks Player Prop Facts

• Gabriel Moreno has hit a home run in four of his last seven appearances with the Diamondbacks as underdogs against NL West opponents.
• Zac Gallen has recorded a win in each of his last five appearances against NL West opponents.
• Zac Gallen has recorded five or more strikeouts in each of his last 12 appearances against the Giants.
• Lourdes Gurriel Jr. has recorded at least one hit in each of his last 12 road appearances against the Giants.
• Corbin Carroll ranks 6th amongst qualified players for Slugging Percentage (.554) this season.

Matchup/League Facts

• The Giants rank 1st in the league for home runs allowed this season (124).
• The Giants rank 29th in the league for steals this season (64).
• The Diamondbacks rank T1st in the league for triples this season (35).
• The Diamondbacks rank 2nd in the league for RBIs this season (697).

Diamondbacks vs Giants Prediction

The Giants have won their last three head-to-head meetings against the Dbacks, but both teams are tied 2-2 wins in their last 4 meetings in San Francisco. Over is 8-2-1 in their last 11 meetings.

In this Diamondbacks vs Giants Prediction, the Giants are coming as -140 home favorites. Zach Gallen is looking like his former self in his last three starts, where he has back-to-back shutout starts and just one earned runs in his last 18 innings pitched. He has given up only one run in his previous start against the Giants this season, while on the flip side, Ray has been struggling for the Giants lately, having given up 13 runs in 13.3 innings pitched across his last three starts. I will take a stab with the road dog and hoping that Gallen continues to be hot on the mound for the Dbacks. Take the Arizona Diamondbacks and the plus money on the road.