Arizona Diamondbacks vs San Diego Padres Prediction 9/28/2025 Today’s MLB Picks

The Arizona Diamondbacks and San Diego Padres meet Sunday in MLB action at Petco Park. Here’s a Arizona Diamondbacks vs San Diego Padres Prediction. This article will include a Arizona Diamondbacks vs San Diego Padres Pick.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks are 80-81 on the year after playing the Dodgers. The Arizona Diamondbacks are batting .251 on the season, have a .324 OBP, and a .433 slugging percentage. The Arizona Diamondbacks pitching staff has a 4.45 ERA and a 1.31 WHIP. Geraldo Perdomo leads the Arizona Diamondbacks with 171 hits and 98 RBI while Corbin Carroll and Ketel Marte have combined for 281 hits and 155 RBI.

Brandon Pfaadt gets the ball for the Arizona Diamondbacks, and he is 13-8 with a 5.00 ERA and 142 strikeouts this season. Pfaadt is 3-2 with a 3.23 ERA and 45 strikeouts in his career against the San Diego Padres.

San Diego Padres Betting Preview

The San Diego Padres are 89-72 on the year after playing the Brewers. The San Diego Padres are batting .252 on the season, have a .320 OBP, and a .389 slugging percentage. The San Diego Padres pitching staff has a 3.63 ERA and a 1.21 WHIP. Luis Arraez leads the San Diego Padres with 181 hits and 61 RBI while Manny Machado and Fernando Tatis Jr. have combined for 325 hits and 164 RBI.

JP Sears gets the ball for the San Diego Padres, and he is 8-11 with a 5.12 ERA and 113 strikeouts this season. Sears is 0-1 with a 6.55 ERA and 10 strikeouts in his career against the Arizona Diamondbacks.

Arizona Diamondbacks @ San Diego Padres Betting Trends: September 28, 2025

• Probable Starting Pitcher: TBD

Why the San Diego Padres will win

• The Padres have won seven of their last eight day games against National League opponents that held a losing record.
• The Diamondbacks have lost seven of their last eight day games against National League opponents following a loss.
• The Padres have covered the run line in seven of their last eight day games against NL West opponents.
• The Diamondbacks have failed to cover the run line in seven of their last eight games against National League opponents following a loss.
• The Diamondbacks have trailed after 5 innings in each of their last five games against opponents that held a winning record.

• Probable Starting Pitcher: Brandon Pfaadt      Record this season: 13-8      ERA: 5.00
• Road Record: 4-5
• Last 5 against Padres: 3-1

Why the Arizona Diamondbacks will win

• The Diamondbacks have won each of their last four day games against the Padres following a loss.
• The Padres have lost each of their last four day games against the Diamondbacks at Petco Park following a win.
• The Diamondbacks have covered the run line in each of their last four day games at Petco Park following a loss.
• The Padres have failed to cover the run line in five of their last six games against the Diamondbacks following a win.

Total Runs Facts

• Four of the Padres’ last five day games after playing the previous day have gone UNDER the total runs line.
• Each of the Diamondbacks’ last three day games against NL West opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Padres’ last eight home games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Diamondbacks’ last four road games against National League opponents.

San Diego Padres Player Prop Facts

• Jackson Merrill has hit a home run in four of the Padres’ last five games against NL opponents that held a losing record.
• Luis Arraez has recorded at least one hit in each of his last 13 appearances after playing the previous day.
• Manny Machado has recorded a Double in four of his last five appearances in day games against NL West teams that held a losing record.

Arizona Diamondbacks Player Prop Facts

• Geraldo Perdomo has recorded at least one hit in each of the Diamondbacks’ last seven road games.
• Brandon Pfaadt has recorded five or more strikeouts in 12 of his last 13 appearances in day games against teams that held a winning record.
• Geraldo Perdomo has hit a home run in two of the Diamondbacks’ last three road games against NL opponents.

Arizona Diamondbacks vs San Diego Padres Prediction

The Padres have nothing to play for, as they’re locked into a playoff series with the Cubs. I wouldn’t be surprised if key players sit. Sears has also been awful since coming over from the Athletics, as he’s allowed 24 hits and 13 earned runs in his last 19 innings. However, the Diamondbacks have played depressed ball since getting bounced from the playoff race, and Pfaadt doesn’t inspire confidence with his 5.00 ERA and 1.33 WHIP. In 75.1 road innings, Pfaadt has a 7.29 ERA and .310 allowed batting average. Backups or not for the Padres, I’m siding with the home team.

Randy Chambers's Pick: San Diego Padres