Arizona Diamondbacks vs San Diego Padres Prediction 9/27/2025 Today’s MLB Picks

The Arizona Diamondbacks and San Diego Padres meet Saturday in MLB action at Petco Park. Here’s a Arizona Diamondbacks vs San Diego Padres Prediction. This article will include a Arizona Diamondbacks vs San Diego Padres Pick.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks are 80-80 on the year after playing the Dodgers. The Arizona Diamondbacks are batting .251 on the season, have a .325 OBP, and a .433 slugging percentage. The Arizona Diamondbacks pitching staff has a 4.44 ERA and a 1.32 WHIP. Geraldo Perdomo leads the Arizona Diamondbacks with 171 hits and 98 RBI while Corbin Carroll and Ketel Marte have combined for 281 hits and 155 RBI.

Eduardo Rodriguez gets the ball for the Arizona Diamondbacks, and he is 9-8 with a 4.91 ERA and 137 strikeouts this season. Rodriguez is 1-1 with a 2.30 ERA and 12 strikeouts in his career against the San Diego Padres.

San Diego Padres Betting Preview

The San Diego Padres are 88-72 on the year after playing the Brewers. The San Diego Padres are batting .252 on the season, have a .321 OBP, and a .388 slugging percentage. The San Diego Padres pitching staff has a 3.64 ERA and a 1.21 WHIP. Luis Arraez leads the San Diego Padres with 180 hits and 61 RBI while Manny Machado and Fernando Tatis Jr. have combined for 324 hits and 163 RBI.

Michael King gets the ball for the San Diego Padres, and he is 5-3 with a 3.57 ERA and 73 strikeouts this season. King is 2-0 with a 0.00 ERA and 8 strikeouts in his career against the Arizona Diamondbacks.

Arizona Diamondbacks @ San Diego Padres Betting Trends: September 27, 2025

• Probable Starting Pitcher: Michael King      Record this season: 5-3      ERA: 3.57
• Home Record: 3-2
• Last 5 against Diamondbacks: 2-0

Why the San Diego Padres will win

• The Padres have won six of their last seven games against NL West opponents.
• The Diamondbacks have lost four of their last five games against NL West opponents.
• The Padres have covered the run line in each of their last four night games against National League opponents.
• The Diamondbacks have failed to cover the run line in each of their last four games following a loss.
• The Diamondbacks have trailed after 5 innings in each of their last four games as underdogs.

• Probable Starting Pitcher: Eduardo Rodriguez      Record this season: 9-8      ERA: 4.91
• Road Record: 6-6
• Last 5 against Padres: 1-1

Why the Arizona Diamondbacks will win

• The Padres have lost seven of their last eight games as home favorites against the Diamondbacks following a home win.
• The Diamondbacks have won five of their last six games as road underdogs against the Padres following a road loss.
• The underdogs have covered the run line in eight of the last nine games between the Diamondbacks and Padres at Petco Park.
• The Padres have failed to cover the run line in eight of their last nine games as home favorites against the Diamondbacks following a win.

Total Runs Facts

• Nine of the last 11 games between the Diamondbacks and Padres at Petco Park have gone OVER the total runs line.
• Three of the Diamondbacks’ last four road games have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Padres’ last seven night games against National League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the Diamondbacks’ last seven night games.

San Diego Padres Player Prop Facts

• Jackson Merrill has hit a home run in three of the Padres’ last four games as favorites against NL opponents.
• Luis Arraez has recorded at least one hit in each of his last 12 appearances after playing the previous day.

Arizona Diamondbacks Player Prop Facts

• Eduardo Rodriguez has recorded a win in each of his last four appearances against opponents that held a winning record.
• James McCann has hit a home run in three of his six previous appearances at Petco Park against NL West opponents that held a winning record.
• Ildemaro Vargas has recorded at least one hit in each of his last nine appearances in night games against teams that held a winning record.
• Corbin Carroll ranks 7th amongst qualified players for Slugging Percentage (.541) this season.

Matchup/League Facts

• The Padres rank 2nd in the league for runs allowed this season (616).
• The Padres rank 28th in the league for home runs this season (148).
• The Diamondbacks rank 4th in the league for runs scored this season (786).
• The Diamondbacks rank 4th in the league for slugging percentage this season (.433).

Arizona Diamondbacks vs San Diego Padres Prediction

The Diamondbacks have nothing to play for now that they’re out of the playoff race, and while Rodriguez has been improved this month, he has a 4.91 ERA and 1.56 WHIP on the season. In 76 road innings, Rodriguez has a 4.74 ERA and .294 allowed batting average. The Padres are heading into the playoffs on a hot streak and while King has been struggling in recent starts, he has a 3.57 ERA and 1.20 WHIP on the season. In 45.1 home innings, King has a 2.58 ERA and .193 allowed batting average. I’ll roll with the hot hand and side with the Padres.