Arizona Diamondbacks vs Cincinnati Reds Prediction 6/6/25 MLB Picks

The Arizona Diamondbacks and the Cincinnati Reds meet Friday in MLB action from Great American Ballpark. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Arizona Diamondbacks vs. Cincinnati Reds prediction.

Starting Pitching Matchup

The Arizona Diamondbacks will send out Eduardo Rodriguez for the start here, and he is 1-3 with a 7.05 ERA and 52 strikeouts this season. In his career, Rodriguez is 1-1 with a 2.77 ERA and 11 strikeouts against Cincinnati. Nick Lodolo will get the start for the Reds here and is 4-4 with a 3.10 ERA and 60 strikeouts this season. This will be Lodolo’s first career start against the Diamondbacks.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to build on their 11-10 win over the Atlanta Braves last time out to improve to 31-31 on the year. After this series, the Diamondbacks will head home for a series against the Seattle Mariners.

Diamondbacks Win Four In A Row

Corbin Carroll has 65 hits with 18 home runs, 39 RBIs, 6 triples, and 12 doubles, while Josh Naylor has 67 hits with 14 doubles, 7 home runs, and 39 RBIs as well this season. Eugenio Suarez has also added 16 home runs and 46 RBIs, while Geraldo Perdomo has 42 RBIs. Naylor has also chipped in 9 stolen bases as well up to this point in the year, while Carroll has the unfortunate distinction of leading the Diamondbacks with 67 strikeouts so far this season. Carroll also has 10 stolen bases, and Perdomo has a team-high 11 stolen bases as well this season.

Why the Arizona Diamondbacks will win

• The Diamondbacks have won each of their last seven games at Great American Ball Park following a win.
• The Reds have lost seven of their last eight games against the Diamondbacks following a home loss.
• The Diamondbacks have covered the run line in each of their last 10 road games against the Reds following a win.
• The Reds have failed to cover the run line in nine of their last 10 home games against the Diamondbacks following a loss.

Arizona Diamondbacks Player Prop Facts

• Eugenio Suarez has hit at least one home run in four of the Diamondbacks’ last five night games against NL Central opponents that held a losing record.
• Ketel Marte has recorded at least one RBI in each of his last four appearances with the Diamondbacks as road favorites against NL Central opponents.
• Ketel Marte has scored at least one run in each of his last six road appearances against NL Central opponents.
• Eduardo Rodriguez has recorded five or more strikeouts in each of his last 18 appearances against opponents that held a losing record.
• Lourdes Gurriel Jr. has recorded at least one Single in each of his last eight appearances against NL Central opponents.
• Eduardo Rodriguez has recorded a win in each of his last nine Friday appearances against teams that held a losing record.
• Eugenio Suarez has recorded a Double in three of the Diamondbacks’ last four road games against NL opponents.
• Josh Naylor has recorded at least one hit in each of his last 13 appearances against NL Central opponents that held a losing record.
• Corbin Carroll ranks 5th in the league in Home Runs (18) this season.

Cincinnati Reds Recap

The Cincinnati Reds come into this game looking to bounce back from their 9-1 loss at the hands of the Milwaukee Brewers to slip to 30-33 on the year. After this series, the Reds will head on the road for a series against the Cleveland Guardians.

Reds Drop 4 Of Their Last 5

Elly De La Cruz has 62 hits with 12 home runs, 43 RBIs, and 19 stolen bases, while TJ Friedl has 68 hits with 11 doubles and 20 RBIs with 9 stolen bases. Gavin Lux has added 52 hits with a team-high 14 doubles and 22 RBIs, while Spencer Steer has 4 home runs and 18 RBIs, and Matt McLain has added 6 homers, 19 RBIs, and 11 stolen bases as well on the year. Jose Trevino’s also chipped in 14 doubles this season.

Why the Cincinnati Reds will win

• The underdogs have won seven of the Diamondbacks’ last eight games.
• The Diamondbacks have lost six of their last seven games as favorites following a win.
• The Diamondbacks have failed to cover the run line in each of their last six games as road favorites.
• The underdogs have covered the run line in seven of the Diamondbacks’ last eight games.

Cincinnati Reds Player Prop Facts

• Tyler Stephenson has hit a home run in each of his last two appearances after not playing the previous day.
• Elly De La Cruz has scored at least one run in seven of the Reds’ last eight games as underdogs.
• Nick Lodolo has recorded six or more strikeouts in nine of his last 10 appearances with the Reds as home underdogs.
• TJ Friedl has recorded at least one hit in each of the Reds’ last eight night games.
• Nick Lodolo has recorded a win in each of his last three appearances against NL West opponents.
• Gavin Lux has recorded a Double in each of his last three appearances against the Diamondbacks.
• Garrett Hampson has recorded at least one RBI in four of his last five appearances with his team as an underdog against the Diamondbacks.
• TJ Friedl has recorded at least one Single in each of the Reds’ last seven night games.
• Elly De La Cruz ranks T5th in the league in Steals (19) this season.

Total Runs Facts

• Four of the Reds’ last five home games against NL West opponents have gone OVER the total runs line.
• Four of the Diamondbacks’ last five games as favorites have gone OVER the total runs line.

Arizona Diamondbacks vs. Cincinnati Reds Prediction

I’m on the Diamondbacks in this one. I am not a fan at all of this Diamondbacks bullpen, as they’ve had a tendency to make life a lot harder for the team than things have needed to be in recent games. However, I’d be remiss if I just ignored how good the Diamondbacks looked offensively in that series against the Braves, and Arizona’s just rolling at the plate right now, which is not something we can say for the Cincinnati Reds. I think Arizona finds a way to deliver here and get the job done, so give me Arizona here.