Reds vs Astros Prediction 5/10/25 MLB Picks

Houston Astros Betting Preview

The Houston Astros are 19-18 this year after they won game one on Friday night by a score of 3-0. Houston scored one run in the second and two in the fifth for the victory. The Astros recorded 12 hits in the game and they were led by Pena, Paredes, and Dezenzo, who all had one RBI in the win. Houston started Brown, who allowed two hits and zero earned runs over 5.2 innings for the win, while Hader picked up the save. 

Prior to this series, the Astros lost two out of three against the Brewers and two out of three against the White Sox. Houston has lost five of their last eight games and they are currently third in the AL West standings. The Houston pitching staff has a 3.27 ERA with a 1.13 WHIP and a .213 opponent batting average, while their offense has scored 148 runs with a .244 batting average and a .314 on base percentage this season. Jeremy Pena has led Houston with five home runs and 17 RBIs, while Isaac Paredes has added four home runs and 16 RBIs this year. The projected starting pitcher for Houston is Lance McCullers Jr., who is 0-0 with a 0.00 ERA and a 1.64 WHIP over 3.2 innings pitched this year. 

Why the Reds will beat the Astros 

• The underdogs have won eight of the last nine games between the Reds and Astros.
• The Astros have lost each of their last five games as favorites against National League opponents following a home win.
• The Reds have covered the run line in 16 of their last 18 games against AL West opponents that held a winning record.
• The Astros have failed to cover the run line in seven of their last eight games against National League opponents that held a losing record.

Total Runs Facts

• Each of the Astros' last five night games against National League opponents have gone UNDER the total runs line.
• Six of the Reds' last seven road games have gone UNDER the total runs line.
• The 'Inning 1 UNDER 0.5 runs' market has hit in 17 of the Astros' last 19 home games against National League opponents.
• The 'Inning 1 OVER 0.5 runs' market has hit in each of the Reds' last seven Saturday night games against AL West opponents.

Houston Astros Player Prop Facts

• Yainer Diaz has hit a home run in three of the Astros' last four games at Daikin Park against NL Central opponents that held a losing record.
• Brendan Rodgers has recorded a Double in each of his last five home appearances against NL Central opponents that held a losing record.
• Yainer Diaz has recorded at least one RBI in five of the Astros' last six games as home favorites against NL Central opponents.
• Christian Walker has scored a run in five of the Astros' last six home games.
• Jeremy Pena has recorded at least one Single in each of the Astros' last seven home games.
• Jeremy Pena has recorded at least one hit in each of the Astros' last 13 games at Daikin Park.

Cincinnati Reds Player Prop Facts

• TJ Friedl has scored a run in five of his last six road appearances against AL West opponents.
• Will Benson has recorded at least one RBI in four of his last five appearances against AL West opponents.
• Jake Fraley has hit a home run in two of his last three appearances with the Reds against AL opponents.
• Jose Trevino has recorded a Double in four of his last five appearances against AL opponents.
• Austin Hays has recorded at least one Single in each of his last eight appearances with his team as an underdog.
• Brady Singer has recorded five or more strikeouts in each of his last seven appearances against AL West opponents that held a winning record.
• Austin Hays has recorded at least one hit in each of his last nine appearances with his team as an underdog against AL opponents.

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Reds vs Astros Prediction 

Houston was able to pick up the win in a low scoring game on Friday night and they are 12-7 at home. The Astros have only allowed one run in their last two games and they are starting McCullers Jr., who is making just his second start of the year. Cincinnati is 10-11 on the road and they have lost six of their last eight games overall. The Reds are starting Singer, who has allowed two earned runs or fewer in two of his last three starts. I don’t like anything about how Cincinnati is playing right now, but I do trust Singer more than McCullers Jr. at this stage of the season. Take the Reds to win.