San Diego Padres vs New York Yankees Prediction 5/7/25 MLB Picks

New York Yankees (20-16) vs San Diego Padres (23-12)

Game Info: Wednesday, May 7, 2025 at 7:05 pm (Yankee Stadium)

D. Cease (R) vs M. Fried (L)

Betting Odds: New York Yankees -180 / San Diego Padres +150 --- Over/Under: 8 Click Here for the Latest Odds

Where to Watch: MLB Net

In this article, we will formulate a Padres vs Yankees prediction for this MLB game on Wednesday, May 7, at Yankee Stadium in Bronx, New York. Let’s take a look at the prediction for this MLB matchup.

San Diego Padres Betting Preview

The San Diego Padres (23-12, 9-8 Away) failed to match their previous longest winning run of seven games as they succumbed to a 12-3 defeat to the Yankees on Tuesday. San Diego swept the Giants and Pirates and won Game 1 of the current series in New York, but their positive streak ended last night, allowing a season-high 12 runs in a loss. Michael King pitched for 6.0 innings in a no-decision, allowing two runs on three hits with two strikeouts and two walks. Adrian Morejon took the loss.

This year, the Padres average 4.00 runs per game (19th in the MLB) on a .259/.327/.387 triple-slash. When it comes to pitching, the Padres’ staff has a 3.01 ERA (3rd) and 1.16 WHIP (5th). Fernando Tatis Jr. leads the Padres with a .321 batting average, eight home runs, and 19 RBI this season.

Dylan Cease will take the mound for the Padres on Wednesday. The 29-year-old right-hander has a 1-2 record in seven starts this year with a 5.61 ERA and 1.60 WHIP in 33.2 innings.

New York Yankees Betting Preview

The New York Yankees (20-16, 12-8 Home) were on the brink of losing their fourth consecutive game for the first time this season, but a big 7th inning in last night's 12-3 victory over the Padres helped them to snap the losing streak. The Yankees scored ten runs in the 7th and dismantled San Diego, who had a 3-2 lead up to that point. Before this series, the Yankees lost the series to the Orioles and Rays. Austin Wells blasted the first grand slam of his career and led the Yanks with five RBI, while Clarke Schmidt pitched for 6.0 innings in a no-decision, allowing two runs on seven hits with four strikeouts and one walk. Fernando Cruz was credited with the win.

This season, the Yankees average 5.61 runs per game (2nd in the MLB) on a .262/.346/.470 slash line. Regarding pitching, the Yankees’ staff has a 3.62 ERA (10th) and 1.20 WHIP (9th). Aaron Judge leads the Yankees with a .412 batting average, 12 home runs, and 34 RBI this season.

The projected starting pitcher for the Yankees is Max Fried, who is 6-0 in seven starts this season, with a 1.01 ERA and 0.94 WHIP in 44.2 innings.

Total Runs Facts

  • Eight of the Yankees' last nine games against National League opponents have gone OVER the total runs line.
  • Five of the Padres' last six road games after playing the previous day have gone UNDER the total runs line.
  • The 'Inning 1 UNDER 0.5 runs' market has hit in each of the Padres' last five games against American League opponents.
  • The 'Inning 1 OVER 0.5 runs' market has hit in 10 of the Yankees' last 12 games as favorites against NL West opponents.

Matchup/League Facts

  • The Yankees rank 1st in the league for slugging percentage this season (.470).
  • The Yankees rank 1st in the league for on-base percentage this season (.346).
  • The Padres rank 1st in the league for runs allowed this season (110).
  • The Padres rank T2nd in the league for home runs allowed this season (28).

Padres vs Yankees Prediction

The Yankees won six of the previous ten H2H encounters, including five of the last seven. Max Fried is probably the best pitcher in the MLB at the moment, but I think the Padres can score at least two runs off him on Wednesday, although he allowed multiple runs in just two starts this year. Fried allowed a .304 BA in 79 at-bats against the Padres. Dylan Cease, on the other hand, surrendered multiple runs in all but one start this year, while he allowed a .314 BA in 35 at-bats against the Yankees. I am going with over mainly because of Cease, but I am also backing the Padres, who are good against southpaws (.243 BA in 366 at-bats) to trouble Fried.

Oliver’s Pick Over 7.5

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The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

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