Giants vs Cubs Prediction 5/7/25 MLB Picks

Chicago Cubs Betting Preview

The Chicago Cubs are 22-15 this season after they lost game two by a score of 14-5 on Tuesday night. Chicago trailed for most of the game, but they scored two runs in the bottom of the ninth to tie it, before losing in extra innings. The Cubs recorded eight hits and they committed two errors in the game, while they were led by Amaya, who went 1-3 with one home run and two RBIs in the loss. Chicago started Rea, who allowed eight hits and four earned runs over 5.0 innings, while Pressly allowed five hits and eight earned runs without recording an out for the loss. 

Prior to this series, the Cubs won two out of three against the Brewers and two out of three against the Pirates. Chicago has won four of their last six games, and they are currently first in the NL Central standings. The Chicago pitching staff has a 3.97 ERA with a 1.30 WHIP and a .245 opponent batting average, while their offense has scored 222 runs with a .261 batting average and a .337 on-base percentage this season. Kyle Tucker has led Chicago with nine home runs, 31 RBIs, and nine stolen bases, while Seiya Suzuki has added nine home runs and 31 RBIs this year. The projected starting pitcher for Chicago is Ben Brown, who is 3-2 with a 4.88 ERA and a 1.66 WHIP over 31.1 innings pitched this season. 

Why the Giants will beat the Cubs 

• The Giants have won five of their last six games as underdogs after going to extra innings.
• The Cubs have lost five of their last seven games as home favorites following an extra-innings loss.
• The Giants have covered the run line in eight of their last nine games as road underdogs after going to extra innings.
• The Cubs have failed to cover the run line in 14 of their last 15 Wednesday games as favorites.
• The Cubs have trailed after 3 innings in each of their last five Wednesday games against National League opponents that held a winning record.

Total Runs Facts

• Each of the Giants' last 12 games as road underdogs have gone OVER the total runs line.
• Each of the Cubs' last four games against NL West opponents have gone OVER the total runs line.
• The 'Inning 1 UNDER 0.5 runs' market has hit in each of the Cubs' last six home games.
• The 'Inning 1 UNDER 0.5 runs' market has hit in 11 of the Giants' last 12 games as underdogs against NL Central opponents.

Giants vs Cubs Prediction 

San Francisco was able to erupt for nine runs in the 11th inning on Tuesday night for the win, but they can’t be happy with their bullpen blowing the lead in the ninth. The Giants are 11-9 on the road this year, while the Cubs are 10-8 at home. Chicago continues to be a very dangerous offensive team, but they will go against Robbie Ray, who has allowed two earned runs or fewer in four of his last five starts. Chicago is starting Ben Brown, who has allowed one earned run or fewer in three of his last four starts, but has allowed 5+ earned runs in two of his last five as well. I really like how Ray is pitching for the Giants, and I am going to take them with the plus money.